KEGG   ORTHOLOGY: K04835
Entry
K04835                      KO                                     
Symbol
mal
Name
methylaspartate ammonia-lyase [EC:4.3.1.2]
Pathway
map00630  Glyoxylate and dicarboxylate metabolism
map00660  C5-Branched dibasic acid metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
Module
M00740  Methylaspartate cycle
Reaction
R03696  L-threo-3-methylaspartate ammonia-lyase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    K04835  mal; methylaspartate ammonia-lyase
   00660 C5-Branched dibasic acid metabolism
    K04835  mal; methylaspartate ammonia-lyase
Enzymes [BR:ko01000]
 4. Lyases
  4.3  Carbon-nitrogen lyases
   4.3.1  Ammonia-lyases
    4.3.1.2  methylaspartate ammonia-lyase
     K04835  mal; methylaspartate ammonia-lyase
Other DBs
COG: COG3799
GO: 0050096
Genes
AFM: AFUA_3G00790
NFI: NFIA_001410
AOR: AO090010000710
AFV: AFLA_014211
ACHE: ACHE_70014S
PDP: PDIP_33520
ECE: Z0892
ECS: ECs_0761
ECF: ECH74115_0829
ETW: ECSP_0779
EOC: CE10_0730
EFE: EFER_2378
SDY: SDY_0673
KOX: KOX_14665
KOE: A225_1756
CKO: CKO_02419
CAMA: F384_03285
YEN: YE4043
YEY: Y11_31521
YEW: CH47_3688
YET: CH48_1495
YAL: AT01_1098
YIN: CH53_313
YRO: CH64_1340
MMK: MU9_1023
PPUL: RO07_15990
BPER: BN118_0709
MLO: mlr6095
MESJ: MJ8_14450
TDE: TDE_2235
TPED: TPE_1176
DTU: Dtur_1344
CTC: CTC_02563
CSQ: CSCA_4328
DSY: DSY3233
DHD: Dhaf_4400
DRM: Dred_2689
AACX: DEACI_0128
CTHM: CFE_0619
AMT: Amet_3414
PUF: UFO1_3073
PFT: JBW_01516
SOVA: SOV_11890
MMAR: MODMU_4014
KAL: KALB_5717
HAL: VNG_2289G(mal)
HSL: OE_4207F(mal)
SALI: L593_04670
HMA: rrnAC0687(mal)
HHI: HAH_1339(mal)
HMU: Hmuk_2982
HALL: LC1Hm_2319(mal)
HTU: Htur_1592
NMG: Nmag_3336(mal)
NAT: NJ7G_3291
 » show all
Reference
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
  Sequence
[hma:rrnAC0687]
Reference
  Authors
Raj H, Puthan Veetil V, Szymanski W, Dekker FJ, Quax WJ, Feringa BL, Janssen DB, Poelarends GJ.
  Title
Characterization of a thermostable methylaspartate ammonia lyase from Carboxydothermus hydrogenoformans.
  Journal
Appl Microbiol Biotechnol 94:385-97 (2012)
DOI:10.1007/s00253-011-3615-6
  Sequence
[chy:CHY_0484]
LinkDB

KEGG   ENZYME: 4.3.1.2
Entry
EC 4.3.1.2                  Enzyme                                 
Name
methylaspartate ammonia-lyase;
beta-methylaspartase;
3-methylaspartase;
L-threo-3-methylaspartate ammonia-lyase
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
Sysname
L-threo-3-methylaspartate ammonia-lyase (mesaconate-forming)
Reaction(IUBMB)
L-threo-3-methylaspartate = mesaconate + NH3 [RN:R03696]
Reaction(KEGG)
R03696
Substrate
L-threo-3-methylaspartate [CPD:C03618]
Product
mesaconate [CPD:C01732];
NH3 [CPD:C00014]
Comment
A cobalamin protein.
History
EC 4.3.1.2 created 1961
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec00660  C5-Branched dibasic acid metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04835  methylaspartate ammonia-lyase
Genes
AFMAFUA_3G00790
NFINFIA_001410
AORAO090010000710
AFVAFLA_014211
ACHEACHE_70014S
PDPPDIP_33520
ECEZ0892
ECSECs_0761
ECFECH74115_0829
ETWECSP_0779
ELXCDCO157_0741
ECOOECRM13514_0750
ECOHECRM13516_0697
EOKG2583_0892
ELRECO55CA74_04340
ECMEcSMS35_0749
EUMECUMN_0814
ECTECIAI39_0701
EOCCE10_0730
ELOEC042_0753
EFEEFER_2378
EMAC1192_08695
ESZFEM44_18110
ESFACK8NJ_16265
SESSARI_02201
SDYSDY_0673
SDZAsd1617_00848
SHIGLXH19_15265
ESHC1N69_07900
EPUQVH39_07900
EAXAAHF05_07650
ENTEGXP72_07970
KOXKOX_14665
KOEA225_1756
KOYJ415_22870
KOMHR38_13440
KOKKONIH1_08640
KOCAB185_27495
KLLBJF97_09010
KLWDA718_19620
KGRJJJ10_19550
KPASLUW96_15420
KLCK7H21_19535
KLMBWI76_08475
KLPGUC22_18805
CKOCKO_02419
CFDCFNIH1_13770
CBRAA6J81_09350
CWECO701_15165
CYOCD187_16565
CPOTFOB25_04015
CFQC2U38_07700
CSEDJY391_14750
CAMAF384_03285
CAFAL524_19000
CIFAL515_08250
CFARCI104_08015
CIRC2U53_17235
CIEAN232_22705
CPARCUC49_03400
CTELGBC03_21985
CITZE4Z61_09960
CARSE1B03_08815
CIXM4I31_15970
CIBHF677_016175
CENSP2W74_15920
CITRGUC46_16240
CIQFD428_14755
CIYHAP28_08240
ESCEntcl_1732
KLEAO703_13285
BUFD8682_20785
BFTMNO13_05010
BSELRHD99_04810
YREHEC60_20895
PVJLMA04_06040
YENYE4043
YEPYE105_C3763
YEYY11_31521
YEWCH47_3688
YETCH48_1495
YEFFORC2_0151
YEEYE5303_38771
YALAT01_1098
YINCH53_313
YROCH64_1340
YHID5F51_21360
YELLC20_00182
YCAF0T03_21045
YASN0H69_09490
MMKMU9_1023
HAVAT03_08650
OPODSM2777_13860
PPULRO07_15990
BPEBP0806 BP3177
BPCBPTD_0804 BPTD_3139
BPERBN118_0709
BPETB1917_0643 B1917_2973
BPEUQ425_31590 Q425_7420
BPARBN117_3385 BN117_3938
BPABPP3422 BPP3864
BBHBN112_4085 BN112_4543
BBRBB3872 BB4337
BBMBN115_3544 BN115_4013
BBXBBS798_3652 BBS798_4114
BFZBAU07_20575
BOHAKI39_19475
BGMCAL15_20690
XYKGT347_12540
MLOmlr6095
MLNA9174_31760
MCIMesci_5690
MCICA4R28_21445
MOPMesop_6269
MAMMesau_05741
MAMOA6B35_31635 A6B35_31710
MESWA9K65_030880
MESMEJ066_12585
MJREB229_32430
MERDEB233_30065
MMEILRP31_10480
MESJMJ8_14450
MEWSQAZ47_06665
MEWMQAZ22_06695
RSULN2599_36735
BICLMTR13_26000
PPANESD82_15275
GFUKM031_18930
ALHG6N82_05195
ELQGa0102493_112996
MTARDF168_01552
LBVJYG24_01975
TDETDE_2235
TPITREPR_1304
TPEDTPE_1176
TPKJO40_01075
SCDSpica_1659
PAHPoras_1170
PCRENCTC12858_01580
PSOECE91St14_10350
PETPEIBARAKI_4288
PROJKDN43_05785
TOHBCB71_00035
PITPIN17_0467
PNIJ5A59_01360
DTHDICTH_1229
DTUDtur_1344
CTCCTC_02563
CTETBN906_02814
CLJCLJU_c40610
CAHCAETHG_1904
CSQCSCA_4328
CACECACET_c34410
CCKCcar_17555 Ccar_19615
CEUA7L45_08020
CFMBJL90_02575
CARGRSJ17_03855
CDRKB9W14_23400
CCOHSAMEA4530647_2259
CLOSDMR38_20135
CCAAKQH81_15280
CTAGLL095_20705
CLOORCG18_03800 RCG18_05855
HHWNCTC503_02397
CALEFDN13_04640
OCWOW730_04540
PROQP6M73_02460
PETRQKW49_11540
DSYDSY3233
DHDDhaf_4400
DDHDesde_3779
DMTDESME_13810
DORDesor_5275
DAIDesaci_4373
DMIDesmer_4259
DCADesca_0604
DRMDred_2689
DRUDesru_0927
DFGB0537_13815
FWADCMF_09590
AACXDEACI_0128
ACAEHYG86_02375
CTHMCFE_0619
FMSM1R53_04075
PROMQO263_09920
BYLA4V09_10270
BHANCGC63_11295
BPROPMF13cell1_03217
BCOCBLCOC_23090
BLARLC508_07905
VGUHYG85_02135
VPYHZI73_09950
EMJV1225_12890
EUUADJ67_05945
AMTAmet_3414
TEMJW646_17970
TGCL0P85_10055
TMYTEMA_08780
TPETTPHSE_23060
PBQC3V37_01025
EACEAL2_808p05890
CHYCHY_0484 CHY_0582
TPZTph_c20250
TEPTepRe1_0115
TAETepiRe1_0120
HORHore_15430
HPKHprae_1850
HALSD7D81_15595
IFNGM661_12735
AARAcear_0480
HHLHalha_1649
AFTBBF96_08380
MFOMVZL98_10615
TISP3962_02615
ECOUM1R54_02150
PUFUFO1_3073
PFTJBW_01516
MANAMAMMFC1_00632
STEDSPTER_10690
SSPHSPSPH_031600
SOVASOV_11890
SSIDSPSIL_016820
SACVSPACI_017830
SCAOSCACP_11170
MANRMPAN_001680
XCLG4Z02_00740
TBKHF295_06620
MBJKQ51_00879
TBMBK010_00845
TBZBK011_00735
MSEDE3O41_00265
FRPAX769_17710
NMESH9L09_01760
MHAIOHB01_26590
MMARMODMU_4014
MOMKUM42_03575
KALKALB_5717
MTUACSH63_31865
BSOLFSW04_00285
BALADSM104299_03890
ABAOBEQ56_05600
CPORBED41_14050
APRPKIH16_11020
FVAFV113G1_25160
FULC4N20_01145
FMOC4N19_13190
FHOH9Q81_10155
IPOIlyop_0556
CSOMMKD34_06450
HALVNG_2289G(mal)
HSLOE_4207F(mal)
HANRLJ422_09240
HAGSJT689_10590
HABOJRZ79_08965
HALXM0R89_18080
HAXYNGM07_04610
SALIL593_04670
HMArrnAC0687(mal)
HSINKDQ40_06775
HHIHAH_1339(mal)
HHNHISP_06855
HABSG26_14700
HTABVU17_06525
HALJG9465_08575
HMUHmuk_2982
HALZE5139_02185
HALLLC1Hm_2319(mal)
HAZPGBQ70_02185
HRRHZS55_19995
HPELHZS54_23495
HGIABY42_16395
HTUHtur_1592
HSALJMJ58_00675
HAKZJ0X25_14770
NMGNmag_3336(mal)
HXAHalxa_3157
NATNJ7G_3291
NPENatpe_2592
NVRFEJ81_11890
NPLFGF80_10930
NAYHYG81_14700
HALYHYG82_17320
HJTDVR14_02945
HLOJ0X27_02305
NGENatgr_2182 Natgr_3386
HLCCHINAEXTREME16085
HRUHalru_1550
SAWLNGM29_08780
HALVNGM15_00945
NOUNatoc_1511
HLRHALLA_00800 HALLA_10845
NAJB1756_12015
NAGAArcMg_1647
NANAArc1_1992
NARAQQ977_05690
NBGDV706_12990
NASGCU68_13735
HDABB347_04020
 » show all
Reference
1  [PMID:13618029]
  Authors
BARKER HA, SMYTH RD, WAWSZKIEWICZ EJ, LEE MN, WILSON RM.
  Title
Enzymic preparation and characterization of an alpha-L-beta-methylaspartic acid.
  Journal
Arch Biochem Biophys 78:468-76 (1958)
DOI:10.1016/0003-9861(58)90371-0
Reference
2
  Authors
Bright HJ, Ingraham LL.
  Title
The preparation of crystalline beta-methylaspartase.
  Journal
Biochim Biophys Acta 44:586-588 (1960)
Other DBs
ExplorEnz - The Enzyme Database: 4.3.1.2
IUBMB Enzyme Nomenclature: 4.3.1.2
ExPASy - ENZYME nomenclature database: 4.3.1.2
BRENDA, the Enzyme Database: 4.3.1.2
CAS: 9033-26-5
LinkDB

KEGG   REACTION: R03696
Entry
R03696                      Reaction                               
Name
L-threo-3-methylaspartate ammonia-lyase
Definition
L-threo-3-Methylaspartate <=> Mesaconate + Ammonia
Equation
Reaction class
RC00979  C01732_C03618
Enzyme
Pathway
rn00630  Glyoxylate and dicarboxylate metabolism
rn00660  C5-Branched dibasic acid metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00740  Methylaspartate cycle
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.3  Carbon-nitrogen lyases
   4.3.1  Ammonia-lyases
    4.3.1.2
     R03696  L-threo-3-Methylaspartate <=> Mesaconate + Ammonia
Orthology
K04835  methylaspartate ammonia-lyase [EC:4.3.1.2]
Other DBs
RHEA: 12832
LinkDB

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