| Entry |
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| Name |
3-deoxy-D-manno-octulosonic acid kinase;
kdkA (gene name);
Kdo kinase
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
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| Sysname |
ATP:(Kdo)-lipid IVA 3-deoxy-alpha-D-manno-oct-2-ulopyranose 4-phosphotransferase
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| Reaction(IUBMB) |
alpha-Kdo-(2->6)-lipid IVA + ATP = 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP [RN: R09767]
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| Reaction(KEGG) |
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| Substrate |
alpha-Kdo-(2->6)-lipid IVA;
ATP [CPD: C00002]
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| Product |
4-O-phospho-alpha-Kdo-(2->6)-lipid IVA [CPD: C19877];
ADP [CPD: C00008]
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| Comment |
The enzyme phosphorylates the 4-OH position of Kdo in (Kdo)-lipid IVA.
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| History |
EC 2.7.1.166 created 2010, modified 2011
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| Pathway |
| ec00540 | Lipopolysaccharide biosynthesis |
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| Orthology |
| K11211 | 3-deoxy-D-manno-octulosonic acid kinase |
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| Genes |
» show all
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| Reference |
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| Authors |
Brabetz W, Muller-Loennies S, Brade H |
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| Title |
3-Deoxy-D-manno-oct-2-ulosonic acid (Kdo) transferase (WaaA) and kdo kinase (KdkA) of Haemophilus influenzae are both required to complement a waaA knockout mutation of Escherichia coli. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Harper M, Boyce JD, Cox AD, St Michael F, Wilkie IW, Blackall PJ, Adler B |
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| Title |
Pasteurella multocida expresses two lipopolysaccharide glycoforms simultaneously, but only a single form is required for virulence: identification of two acceptor-specific heptosyl I transferases. |
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| Journal |
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| Reference |
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| Authors |
White KA, Kaltashov IA, Cotter RJ, Raetz CR |
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| Title |
A mono-functional 3-deoxy-D-manno-octulosonic acid (Kdo) transferase and a Kdo kinase in extracts of Haemophilus influenzae. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
White KA, Lin S, Cotter RJ, Raetz CR |
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| Title |
A Haemophilus influenzae gene that encodes a membrane bound 3-deoxy-D-manno-octulosonic acid (Kdo) kinase. Possible involvement of kdo phosphorylation in bacterial virulence. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.7.1.166 |
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| LinkDB |
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