KEGG   ORTHOLOGY: K12503
Entry
K12503                      KO                                     

Name
E2.5.1.68
Definition
short-chain Z-isoprenyl diphosphate synthase [EC:2.5.1.68]
Pathway
ko00900  Terpenoid backbone biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K12503  E2.5.1.68; short-chain Z-isoprenyl diphosphate synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases
    K12503  E2.5.1.68; short-chain Z-isoprenyl diphosphate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.68  (2Z,6E)-farnesyl diphosphate synthase
     K12503  E2.5.1.68; short-chain Z-isoprenyl diphosphate synthase
Prenyltransferases [BR:ko01006]
 Terpene biosynthesis
  Prenyl diphosphate synthase
   K12503  E2.5.1.68; short-chain Z-isoprenyl diphosphate synthase
Other DBs
RN: R08528
COG: COG0020
GO: 0033850
Genes
BCJ: BCAM2067(uppS)
BCEO: I35_5903(uppS)
BCED: DM42_5933(uppS)
BCEP: APZ15_28620
BDL: AK34_3632(uppS)
BCON: NL30_01965
BSEM: WJ12_30400
BMEC: WJ16_28400 WJ16_28955
REL: REMIM1_PE00482
HDT: HYPDE_40383
ACR: Acry_2740
AMV: ACMV_30690(uppS)
MTU: Rv1086
MTV: RVBD_1086
MTC: MT1118(uppS-1)
MRA: MRA_1096
MTUR: CFBS_1149
MTD: UDA_1086
MTUC: J113_07610
MTUE: J114_05860
MTUL: TBHG_01069
MTUT: HKBT1_1148
MTUU: HKBT2_1153
MBB: BCG_1144
MBT: JTY_1117
MBX: BCGT_0905
MAF: MAF_10990
MMIC: RN08_1217
MLE: ML2467
MLB: MLBr02467
MPA: MAP_2703c
MAO: MAP4_1113
MAVI: RC58_05530
MAVU: RE97_05525
MAV: MAV_1211
MIT: OCO_11180
MIA: OCU_11160
MID: MIP_01801
MYO: OEM_11290
MIR: OCQ_11190
MLP: MLM_1159
MUL: MUL_0193(uppS)
MMI: MMAR_4380(uppS)
MMAE: MMARE11_42000(uppS)
MMM: W7S_05465
MLI: MULP_04595(uppS_1)
MHAD: B586_07025
MSHG: MSG_03938
MSM: MSMEG_5256(uppS)
MGI: Mflv_2055
MPHL: MPHLCCUG_04253(uppS_2)
MVQ: MYVA_1453 MYVA_4488(uppS)
MHAS: MHAS_03234(uppS_2)
MCHT: MCHIJ_25230(uppS_1)
MDR: MDOR_29050(uppS_2)
MAB: MAB_1209
MABB: MASS_1207
MCHE: BB28_06000
MSTE: MSTE_01175
MSAL: DSM43276_01075(uppS_1)
MJD: JDM601_1033(uppS)
MTER: 4434518_01019(uppS_1)
MMIN: MMIN_26790
MHIB: MHIB_05940
ASD: AS9A_3411
MKR: MKOR_40270(uppS_2)
CGL: NCgl0951(Cgl0991)
CGB: cg1130(uppS1)
CGU: WA5_0951(UppS1)
CGT: cgR_1084
CGM: cgp_1130(uppS1)
CGJ: AR0_05470
CEF: CE1055
CDI: DIP0929
CDP: CD241_0835(uppS1)
CDH: CDB402_0808(uppS1)
CDT: CDHC01_0836(uppS1)
CDE: CDHC02_0835(uppS1)
CDR: CDHC03_0833(uppS1)
CDA: CDHC04_0844(uppS1)
CDZ: CD31A_0933(uppS1)
CDB: CDBH8_0880(uppS1)
CDS: CDC7B_0844(uppS1)
CDD: CDCE8392_0836(uppS1)
CDW: CDPW8_0895(uppS1)
CDV: CDVA01_0802(uppS1)
CDIP: ERS451417_00833(uppS1)
CJK: jk1467(uppS1)
CUR: cu0602
CUA: CU7111_0594(uppS1)
CAR: cauri_0927(uppS1)
CPL: Cp3995_0737(uppS1)
CPP: CpP54B96_0736(uppS1)
CPZ: CpPAT10_0723(uppS1)
COR: Cp267_0759(uppS1)
COD: Cp106_0709(uppS1)
COS: Cp4202_0715(uppS1)
CPSE: CPTA_01279
CPSU: CPTB_00253
CPSF: CPTC_01271
CRD: CRES_1604(uppS1)
CUN: Cul210932_0809(uppS1)
CUS: CulFRC11_0776(uppS1)
CUQ: Cul210931_0773(uppS1)
CUZ: Cul05146_0831(uppS1)
CUJ: CUL131002_0787(uppS1)
CVA: CVAR_1939
CTER: A606_07885
CGY: CGLY_06150(uppS1)
COA: DR71_505(uppS)
CSX: CSING_05100(uppS1)
CMQ: B840_03885(uppS1)
CKU: UL82_08070(uppS1)
CCJ: UL81_04280(uppS1)
CMV: CMUST_05540(uppS1)
CEI: CEPID_04395(uppS1)
CTED: CTEST_04345(uppS1)
CUT: CUTER_03825(uppS1)
CDX: CDES_04840(uppS1)
CSP: WM42_0450
CPHO: CPHO_08120
CGV: CGLAU_04350(uppS)
CAQU: CAQU_04415
CAMG: CAMM_08980
CMIN: NCTC10288_01619(uppS1)
CPEG: CPELA_07235(uppS2)
CEE: CENDO_04125(uppS)
CGK: CGERO_03940(uppS)
NFA: NFA_48180
NCY: NOCYR_4592(uppS)
NNO: NONO_c65530(uppS1)
RER: RER_42550
REY: O5Y_19910
ROP: ROP_59180
REQ: REQ_12990
RHB: NY08_4949
RFA: A3L23_03008(uppS)
RHS: A3Q41_00315(uppS)
RHU: A3Q40_02392(uppS)
GBR: Gbro_1657
GOR: KTR9_1618
GRU: GCWB2_08165(uppS)
GOM: D7316_01581(uppS)
TPR: Tpau_3135
SRT: Srot_1973
SCO: SCO3858(SCH69.28c)
SALB: XNR_4115
SMA: SAVERM_3237(uppS1)
SCB: SCAB_33671(uppS1)
SCT: SCAT_3893(uppS)
SFA: Sfla_2240
SBH: SBI_04188
SHY: SHJG_6124
SVE: SVEN_4694
SDV: BN159_3370(uppS1) BN159_7965(uppS2)
SALS: SLNWT_4995
STRP: F750_4567
SALU: DC74_5189
SALL: SAZ_27585
SLV: SLIV_18980(uppS2)
SGU: SGLAU_21635(uppS)
STRE: GZL_03653
SLD: T261_3021
STRM: M444_22050
SAMB: SAM23877_3798(uppS)
SPRI: SPRI_2843
SLE: sle_26800(sle_26800)
SNR: SNOUR_16240(uppS1) SNOUR_37660(uppS)
STRD: NI25_19105
SMAL: SMALA_4868
SLAU: SLA_4877
SRJ: SRO_2758
KSK: KSE_47670(uppS2) KSE_73590(uppS3)
TWH: TWT_331
TWS: TW440(uppS1)
LXX: Lxx16850(uppS)
CMI: CMM_2236(uppS2)
CMS: CMS2423(uppS)
CMC: CMN_02210(uppS2)
MTS: MTES_3009(uppS)
AMIN: AUMI_19640
MALK: MalAC0309_0857(uppS)
LTR: EVS81_11890(uppS)
AGG: C1N71_10560(uppS)
ART: Arth_1173
ARR: ARUE_c12270(uppS1)
ARM: ART_3941
AAU: AAur_1291(uppS)
ACH: Achl_1244
AAI: AARI_07540(uppS1)
KRH: KRH_17650
AUL: DCC27_006410(uppS)
BSAU: DWV08_09005(uppS)
DJJ: COP05_07860(uppS)
JDE: Jden_1887
XCE: Xcel_2629
IDO: I598_3280
CFL: Cfla_0946
CFI: Celf_2942
SERJ: SGUI_1302
BLIN: BLSMQ_1549
BRI: FDF13_08400(uppS)
PAC: PPA0564
PAW: PAZ_c05990(uppS1)
PACC: PAC1_02935
PACH: PAGK_1566
CACN: RN83_03375
PFR: PFREUD_17010(uppS)
PFRE: RM25_1615
PACD: EGX94_03610(uppS)
PPC: HMPREF9154_2688(uppS_2)
MPH: MLP_43780
NCA: Noca_1056
NDK: I601_2034
NBE: Back2_23180(uppS)
PSIM: KR76_07505
MGG: MPLG2_3945(uppS)
TFU: Tfu_0456
NDA: Ndas_0101
NAL: B005_2900(uppS)
TCU: Tcur_1075
SRO: Sros_8524
FAL: FRAAL3564(uppS)
ACE: Acel_1881
NML: Namu_4413
GOB: Gobs_0950
BSD: BLASA_0816(uppS)
MMAR: MODMU_1002(ispU)
KRA: Krad_1106
SEN: SACE_0919(uppS1)
AMD: AMED_8075(uppS)
AMN: RAM_41485
AMM: AMES_7953(uppS)
AMZ: B737_7954(uppS)
AJA: AJAP_04605(uppS1)
AMQ: AMETH_5870(uppS)
AMYY: YIM_05135(uppS1)
AORI: SD37_06185
PDX: Psed_0949
PSEE: FRP1_22395
PSEH: XF36_20635
PAUT: Pdca_10570(uppS_1)
AMI: Amir_0714
SESP: BN6_07920(uppS1)
ALO: CRK61594
SAQ: Sare_0809
MIL: ML5_1100
ASE: ACPL_7710
ACTN: L083_7467
AFS: AFR_39270
ACTS: ACWT_7580
PFLA: Pflav_063400(uppS)
PSUU: Psuf_025250(uppS)
CAI: Caci_0733
SNA: Snas_0732
AHE: Arch_1503
TPYO: X956_02045
ACTO: C3V41_10595(uppS)
TBI: Tbis_3093
ERZ: ER308_17265(uppS)
DRA: DR_2447
DGE: Dgeo_0020
DDR: Deide_01980(uppS)
DGO: DGo_CA2915(uppS)
DFC: DFI_00705
DGA: DEGR_03740(uppS)
TRA: Trad_2870
TTH: TT_C1551
TTJ: TTHA1915
TSC: TSC_c01840(uppS)
TAQ: TO73_0090
MRB: Mrub_0809
MOX: DAMO_2077(ispU)
 » show all
Reference
  Authors
Schulbach MC, Brennan PJ, Crick DC
  Title
Identification of a short (C15) chain Z-isoprenyl diphosphate synthase and a homologous long (C50) chain isoprenyl diphosphate synthase in Mycobacterium tuberculosis.
  Journal
J Biol Chem 275:22876-81 (2000)
DOI:10.1074/jbc.M003194200
  Sequence
[mtu:Rv1086]
LinkDB

KEGG   ENZYME: 2.5.1.68
Entry
EC 2.5.1.68                 Enzyme                                 

Name
(2Z,6E)-farnesyl diphosphate synthase;
(Z)-farnesyl diphosphate synthase;
Z-farnesyl diphosphate synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase
Reaction(IUBMB)
geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2Z,6E)-farnesyl diphosphate [RN:R08528]
Reaction(KEGG)
R08528
Substrate
geranyl diphosphate [CPD:C00341];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
(2Z,6E)-farnesyl diphosphate [CPD:C16826]
Comment
Requires Mg2+ or Mn2+ for activity. The product of this reaction is an intermediate in the synthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of most features of the mycobacterial cell wall, including peptidoglycan, linker unit galactan and arabinan. Neryl diphosphate can also act as substrate.
History
EC 2.5.1.68 created 2007, modified 2010
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K12503  short-chain Z-isoprenyl diphosphate synthase
Genes
BCJ: BCAM2067(uppS)
BCEO: I35_5903(uppS)
BCED: DM42_5933(uppS)
BCEP: APZ15_28620
BDL: AK34_3632(uppS)
BCON: NL30_01965
BSEM: WJ12_30400
BMEC: WJ16_28400 WJ16_28955
REL: REMIM1_PE00482
HDT: HYPDE_40383
ACR: Acry_2740
AMV: ACMV_30690(uppS)
MTU: Rv1086
MTV: RVBD_1086
MTC: MT1118(uppS-1)
MRA: MRA_1096
MTUR: CFBS_1149
MTD: UDA_1086
MTUC: J113_07610
MTUE: J114_05860
MTUL: TBHG_01069
MTUT: HKBT1_1148
MTUU: HKBT2_1153
MBB: BCG_1144
MBT: JTY_1117
MBX: BCGT_0905
MAF: MAF_10990
MMIC: RN08_1217
MLE: ML2467
MLB: MLBr02467
MPA: MAP_2703c
MAO: MAP4_1113
MAVI: RC58_05530
MAVU: RE97_05525
MAV: MAV_1211
MIT: OCO_11180
MIA: OCU_11160
MID: MIP_01801
MYO: OEM_11290
MIR: OCQ_11190
MLP: MLM_1159
MUL: MUL_0193(uppS)
MMI: MMAR_4380(uppS)
MMAE: MMARE11_42000(uppS)
MMM: W7S_05465
MLI: MULP_04595(uppS_1)
MHAD: B586_07025
MSHG: MSG_03938
MSM: MSMEG_5256(uppS)
MGI: Mflv_2055
MPHL: MPHLCCUG_04253(uppS_2)
MVQ: MYVA_1453 MYVA_4488(uppS)
MHAS: MHAS_03234(uppS_2)
MCHT: MCHIJ_25230(uppS_1)
MDR: MDOR_29050(uppS_2)
MAB: MAB_1209
MABB: MASS_1207
MCHE: BB28_06000
MSTE: MSTE_01175
MSAL: DSM43276_01075(uppS_1)
MJD: JDM601_1033(uppS)
MTER: 4434518_01019(uppS_1)
MMIN: MMIN_26790
MHIB: MHIB_05940
ASD: AS9A_3411
MKR: MKOR_40270(uppS_2)
CGL: NCgl0951(Cgl0991)
CGB: cg1130(uppS1)
CGU: WA5_0951(UppS1)
CGT: cgR_1084
CGM: cgp_1130(uppS1)
CGJ: AR0_05470
CEF: CE1055
CDI: DIP0929
CDP: CD241_0835(uppS1)
CDH: CDB402_0808(uppS1)
CDT: CDHC01_0836(uppS1)
CDE: CDHC02_0835(uppS1)
CDR: CDHC03_0833(uppS1)
CDA: CDHC04_0844(uppS1)
CDZ: CD31A_0933(uppS1)
CDB: CDBH8_0880(uppS1)
CDS: CDC7B_0844(uppS1)
CDD: CDCE8392_0836(uppS1)
CDW: CDPW8_0895(uppS1)
CDV: CDVA01_0802(uppS1)
CDIP: ERS451417_00833(uppS1)
CJK: jk1467(uppS1)
CUR: cu0602
CUA: CU7111_0594(uppS1)
CAR: cauri_0927(uppS1)
CPL: Cp3995_0737(uppS1)
CPP: CpP54B96_0736(uppS1)
CPZ: CpPAT10_0723(uppS1)
COR: Cp267_0759(uppS1)
COD: Cp106_0709(uppS1)
COS: Cp4202_0715(uppS1)
CPSE: CPTA_01279
CPSU: CPTB_00253
CPSF: CPTC_01271
CRD: CRES_1604(uppS1)
CUN: Cul210932_0809(uppS1)
CUS: CulFRC11_0776(uppS1)
CUQ: Cul210931_0773(uppS1)
CUZ: Cul05146_0831(uppS1)
CUJ: CUL131002_0787(uppS1)
CVA: CVAR_1939
CTER: A606_07885
CGY: CGLY_06150(uppS1)
COA: DR71_505(uppS)
CSX: CSING_05100(uppS1)
CMQ: B840_03885(uppS1)
CKU: UL82_08070(uppS1)
CCJ: UL81_04280(uppS1)
CMV: CMUST_05540(uppS1)
CEI: CEPID_04395(uppS1)
CTED: CTEST_04345(uppS1)
CUT: CUTER_03825(uppS1)
CDX: CDES_04840(uppS1)
CSP: WM42_0450
CPHO: CPHO_08120
CGV: CGLAU_04350(uppS)
CAQU: CAQU_04415
CAMG: CAMM_08980
CMIN: NCTC10288_01619(uppS1)
CPEG: CPELA_07235(uppS2)
CEE: CENDO_04125(uppS)
CGK: CGERO_03940(uppS)
NFA: NFA_48180
NCY: NOCYR_4592(uppS)
NNO: NONO_c65530(uppS1)
RER: RER_42550
REY: O5Y_19910
ROP: ROP_59180
REQ: REQ_12990
RHB: NY08_4949
RFA: A3L23_03008(uppS)
RHS: A3Q41_00315(uppS)
RHU: A3Q40_02392(uppS)
GBR: Gbro_1657
GOR: KTR9_1618
GRU: GCWB2_08165(uppS)
GOM: D7316_01581(uppS)
TPR: Tpau_3135
SRT: Srot_1973
SCO: SCO3858(SCH69.28c)
SALB: XNR_4115
SMA: SAVERM_3237(uppS1)
SCB: SCAB_33671(uppS1)
SCT: SCAT_3893(uppS)
SFA: Sfla_2240
SBH: SBI_04188
SHY: SHJG_6124
SVE: SVEN_4694
SDV: BN159_3370(uppS1) BN159_7965(uppS2)
SALS: SLNWT_4995
STRP: F750_4567
SALU: DC74_5189
SALL: SAZ_27585
SLV: SLIV_18980(uppS2)
SGU: SGLAU_21635(uppS)
STRE: GZL_03653
SLD: T261_3021
STRM: M444_22050
SAMB: SAM23877_3798(uppS)
SPRI: SPRI_2843
SLE: sle_26800(sle_26800)
SNR: SNOUR_16240(uppS1) SNOUR_37660(uppS)
STRD: NI25_19105
SMAL: SMALA_4868
SLAU: SLA_4877
SRJ: SRO_2758
KSK: KSE_47670(uppS2) KSE_73590(uppS3)
TWH: TWT_331
TWS: TW440(uppS1)
LXX: Lxx16850(uppS)
CMI: CMM_2236(uppS2)
CMS: CMS2423(uppS)
CMC: CMN_02210(uppS2)
MTS: MTES_3009(uppS)
AMIN: AUMI_19640
MALK: MalAC0309_0857(uppS)
LTR: EVS81_11890(uppS)
AGG: C1N71_10560(uppS)
ART: Arth_1173
ARR: ARUE_c12270(uppS1)
ARM: ART_3941
AAU: AAur_1291(uppS)
ACH: Achl_1244
AAI: AARI_07540(uppS1)
KRH: KRH_17650
AUL: DCC27_006410(uppS)
BSAU: DWV08_09005(uppS)
DJJ: COP05_07860(uppS)
JDE: Jden_1887
XCE: Xcel_2629
IDO: I598_3280
CFL: Cfla_0946
CFI: Celf_2942
SERJ: SGUI_1302
BLIN: BLSMQ_1549
BRI: FDF13_08400(uppS)
PAC: PPA0564
PAW: PAZ_c05990(uppS1)
PACC: PAC1_02935
PACH: PAGK_1566
CACN: RN83_03375
PFR: PFREUD_17010(uppS)
PFRE: RM25_1615
PACD: EGX94_03610(uppS)
PPC: HMPREF9154_2688(uppS_2)
MPH: MLP_43780
NCA: Noca_1056
NDK: I601_2034
NBE: Back2_23180(uppS)
PSIM: KR76_07505
MGG: MPLG2_3945(uppS)
TFU: Tfu_0456
NDA: Ndas_0101
NAL: B005_2900(uppS)
TCU: Tcur_1075
SRO: Sros_8524
FAL: FRAAL3564(uppS)
ACE: Acel_1881
NML: Namu_4413
GOB: Gobs_0950
BSD: BLASA_0816(uppS)
MMAR: MODMU_1002(ispU)
KRA: Krad_1106
SEN: SACE_0919(uppS1)
AMD: AMED_8075(uppS)
AMN: RAM_41485
AMM: AMES_7953(uppS)
AMZ: B737_7954(uppS)
AJA: AJAP_04605(uppS1)
AMQ: AMETH_5870(uppS)
AMYY: YIM_05135(uppS1)
AORI: SD37_06185
PDX: Psed_0949
PSEE: FRP1_22395
PSEH: XF36_20635
PAUT: Pdca_10570(uppS_1)
AMI: Amir_0714
SESP: BN6_07920(uppS1)
ALO: CRK61594
SAQ: Sare_0809
MIL: ML5_1100
ASE: ACPL_7710
ACTN: L083_7467
AFS: AFR_39270
ACTS: ACWT_7580
PFLA: Pflav_063400(uppS)
PSUU: Psuf_025250(uppS)
CAI: Caci_0733
SNA: Snas_0732
AHE: Arch_1503
TPYO: X956_02045
ACTO: C3V41_10595(uppS)
TBI: Tbis_3093
ERZ: ER308_17265(uppS)
DRA: DR_2447
DGE: Dgeo_0020
DDR: Deide_01980(uppS)
DGO: DGo_CA2915(uppS)
DFC: DFI_00705
DGA: DEGR_03740(uppS)
TRA: Trad_2870
TTH: TT_C1551
TTJ: TTHA1915
TSC: TSC_c01840(uppS)
TAQ: TO73_0090
MRB: Mrub_0809
MOX: DAMO_2077(ispU)
 » show all
Reference
1  [PMID:11152452]
  Authors
Schulbach MC, Mahapatra S, Macchia M, Barontini S, Papi C, Minutolo F, Bertini S, Brennan PJ, Crick DC.
  Title
Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis.
  Journal
J Biol Chem 276:11624-30 (2001)
DOI:10.1074/jbc.M007168200
  Sequence
[mtu:Rv1086]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.68
IUBMB Enzyme Nomenclature: 2.5.1.68
ExPASy - ENZYME nomenclature database: 2.5.1.68
BRENDA, the Enzyme Database: 2.5.1.68
LinkDB

KEGG   REACTION: R08528
Entry
R08528                      Reaction                               

Name
Z-farnesyl diphosphate synthase
Definition
Geranyl diphosphate + Isopentenyl diphosphate <=> 2-cis,6-trans-Farnesyl diphosphate + Diphosphate
Equation
Reaction class
RC00279  C00129_C16826
Enzyme
Pathway
rn00900  Terpenoid backbone biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K12503  short-chain Z-isoprenyl diphosphate synthase [EC:2.5.1.68]
Other DBs
RHEA: 23303
LinkDB

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