KEGG   ORTHOLOGY: K13309
Entry
K13309                      KO                                     

Name
desII, eryCV
Definition
dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase [EC:4.3.1.30]
Pathway
ko00523  Polyketide sugar unit biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00797  dTDP-D-desosamine biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K13309  desII, eryCV; dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase
Enzymes [BR:ko01000]
 4. Lyases
  4.3  Carbon-nitrogen lyases
   4.3.1  Ammonia-lyases
    4.3.1.30  dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase
     K13309  desII, eryCV; dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase
Other DBs
RN: R08583
Genes
STRE: GZL_03702
STRM: M444_29865
SNR: SNOUR_10125(eryCV)
AER: AERYTH_15835
SEN: SACE_0715(eryCV)
MCAB: HXZ27_06185(rosR)
AEY: CDG81_13215(desII)
AG: AAC68683(desII)
Reference
  Authors
Szu PH, Ruszczycky MW, Choi SH, Yan F, Liu HW
  Title
Characterization and mechanistic studies of DesII: a radical S-adenosyl-L-methionine enzyme involved in the biosynthesis of TDP-D-desosamine.
  Journal
J Am Chem Soc 131:14030-42 (2009)
DOI:10.1021/ja903354k
Reference
  Authors
Ruszczycky MW, Choi SH, Mansoorabadi SO, Liu HW
  Title
Mechanistic studies of the radical S-adenosyl-L-methionine enzyme DesII: EPR characterization of a radical intermediate generated during its catalyzed dehydrogenation of TDP-D-quinovose.
  Journal
J Am Chem Soc 133:7292-5 (2011)
DOI:10.1021/ja201212f
Reference
PMID:9770448
  Authors
Xue Y, Zhao L, Liu HW, Sherman DH
  Title
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity.
  Journal
Proc Natl Acad Sci U S A 95:12111-6 (1998)
DOI:10.1073/pnas.95.21.12111
  Sequence
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