KEGG   ORTHOLOGY: K14970Help
Entry
K14970                      KO                                     

Name
MEN1, MNN1
Definition
menin
Pathway
ko04934  Cushing syndrome
ko05202  Transcriptional misregulation in cancer
Disease
H00033  Adrenal carcinoma
H00034  Carcinoid
H00045  Pancreatic neuroendocrine tumor
H00246  Primary hyperparathyroidism
H00247  Multiple endocrine neoplasia syndrome
H01102  Pituitary adenomas
H01431  Cushing syndrome
H01522  Zollinger-Ellison syndrome
H01667  Medulloblastoma
H02049  Bilateral macronodular adrenal hyperplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K14970  MEN1, MNN1; menin
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K14970  MEN1, MNN1; menin
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K14970  MEN1, MNN1; menin
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Histone modification proteins
   HMT complexes
    MLL-HCF complex
     K14970  MEN1, MNN1; menin
BRITE hierarchy
Genes
HSA: 4221(MEN1)
PTR: 743979(MEN1)
PPS: 100995950(MEN1)
GGO: 101127917(MEN1)
PON: 100441476(MEN1)
NLE: 100604705(MEN1)
MCC: 106995582(MEN1)
MCF: 102134847(MEN1)
CSAB: 103233027(MEN1)
RRO: 104662845(MEN1)
RBB: 108542951(MEN1)
CJC: 100411101(MEN1)
SBQ: 101054218(MEN1)
MMU: 17283(Men1)
MCAL: 110285613(Men1)
MPAH: 110320933(Men1)
RNO: 29417(Men1)
MUN: 110549349(Men1)
CGE: 100757636(Men1)
NGI: 103738777(Men1)
HGL: 101709865(Men1)
CCAN: 109687171(Men1)
OCU: 103346777(MEN1)
TUP: 102475076(MEN1)
CFA: 483758(MEN1)
VVP: 112924296(MEN1)
AML: 100472417(MEN1)
UAH: 113244156(MEN1)
ORO: 101368194(MEN1)
FCA: 692344(MEN1)
PTG: 102958009(MEN1)
AJU: 113595438(MEN1)
BTA: 539431(MEN1)
BOM: 102272654(MEN1)
BIU: 109554071(MEN1) 109554124
BBUB: 102415673(MEN1)
PHD: 102318263(MEN1)
CHX: 102184226(MEN1)
OAS: 101118395(MEN1)
SSC: 100523533(MEN1)
CFR: 102516114(MEN1)
CDK: 105101561(MEN1)
BACU: 102998963(MEN1)
LVE: 103076298(MEN1)
OOR: 101280709(MEN1)
DLE: 111183792(MEN1)
ECB: 100050500(MEN1)
EPZ: 103559130(MEN1)
EAI: 106833613(MEN1)
MYB: 102259887(MEN1)
MYD: 102752874(MEN1)
MNA: 107533650(MEN1)
HAI: 109384103(MEN1)
RSS: 109450413(MEN1)
DRO: 112317094(MEN1)
PALE: 102881190(MEN1)
LAV: 100666867(MEN1)
TMU: 101346513
SHR: 105750976(MEN1)
PCW: 110195442(MEN1)
OAA: 103169404(MEN1)
LSR: 110477375(MEN1)
PHI: 102103039(MEN1)
PMAJ: 109022439(MEN1)
ETL: 114070360(MEN1)
FPG: 106112054(MEN1)
AAM: 106492959(MEN1)
ASN: 102372086(MEN1)
AMJ: 102569660(MEN1)
PSS: 102444159(MEN1)
CMY: 102936704 102938582(MEN1)
CPIC: 101950064(MEN1)
ACS: 100559104(men1)
PVT: 110089978(MEN1)
PBI: 103066776(MEN1)
PMUR: 107293226(MEN1)
GJA: 107121073(MEN1)
XLA: 100158320(men1.L)
XTR: 549115(men1)
NPR: 108795772(MEN1)
DRE: 30130(men1)
SGH: 107574673 107597878(men1)
IPU: 108268124(men1)
PHYP: 113540615(men1)
AMEX: 103032489(men1)
EEE: 113581812(men1)
TRU: 101075305(men1)
LCO: 104931451(men1)
NCC: 104964257
MZE: 101472638(men1)
OLA: 101155467(men1)
XMA: 102236011(men1)
XCO: 114157510(men1)
PRET: 103480117(men1)
NFU: 107384721(men1)
KMR: 108242247(men1)
LCF: 108879711(men1)
SDU: 111223605(men1)
HCQ: 109508447(men1)
BPEC: 110170768(men1)
MALB: 109957227(men1)
ELS: 105020713(men1)
SFM: 108929688(men1)
PKI: 111858526(men1)
LCM: 102348464(MEN1)
CIN: 104265605
SPU: 589807
APLC: 110988904
SKO: 102807401
DME: Dmel_CG13778(Mnn1)
DER: 6541494
DPE: 6595466
DSI: Dsimw501_GD23452(Dsim_GD23452)
DWI: 6644223
DAZ: 108609462
DHE: 111595934
MDE: 101893252
AAG: 5566912
AME: 410989
BIM: 100741183
BTER: 100642722
SOC: 105198555
MPHA: 105841123
AEC: 105152173
ACEP: 105625896
PBAR: 105431346
HST: 105188760
DQU: 106748770
CFO: 105249839
LHU: 105677685
PGC: 109855468
OBO: 105277452
PCF: 106784226
NVI: 100120096
MDL: 103572953
TCA: 658495
DPA: 109544723
NVL: 108568231
BMOR: 101739588
PMAC: 106709532
PRAP: 110998460
HAW: 110371613
TNL: 113497173
PXY: 105382809
API: 100159871
DNX: 107172992
AGS: 114130622
CLEC: 106667084
ZNE: 110828816
FCD: 110848694
TUT: 107368816
DPTE: 113789375
PCAN: 112569875
CRG: 105324543
MYI: 110449132
LAK: 106167181
SHX: MS3_06331
EGL: EGR_01254
EPA: 110240438
ADF: 107338169
PDAM: 113677576
SPIS: 111344080
APRO: F751_6495
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wu X, Hua X
  Title
Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.
  Journal
Curr Mol Med 8:805-15 (2008)
DOI:10.2174/156652408786733702
Reference
  Authors
Kaji H, Canaff L, Lebrun JJ, Goltzman D, Hendy GN
  Title
Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling.
  Journal
Proc Natl Acad Sci U S A 98:3837-42 (2001)
DOI:10.1073/pnas.061358098
  Sequence
[hsa:4221] [rno:29417]
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