KEGG   ORTHOLOGY: K15793
Entry
K15793                      KO                                     
Symbol
K15793
Name
acyclic sesquiterpene synthase [EC:4.2.3.49 4.2.3.47 3.1.7.6]
Pathway
map00900  Terpenoid backbone biosynthesis
map00909  Sesquiterpenoid and triterpenoid biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R08695  (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-beta-farnesene-forming]
R08697  trans,trans-farnesyl-diphosphate diphosphohydrolase
R09618  (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(3R,6E)-nerolidol-forming]
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K15793  K15793; acyclic sesquiterpene synthase
   00909 Sesquiterpenoid and triterpenoid biosynthesis
    K15793  K15793; acyclic sesquiterpene synthase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.7  Diphosphoric-monoester hydrolases
    3.1.7.6  farnesyl diphosphatase
     K15793  K15793; acyclic sesquiterpene synthase
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.47  beta-farnesene synthase
     K15793  K15793; acyclic sesquiterpene synthase
    4.2.3.49  (3R,6E)-nerolidol synthase
     K15793  K15793; acyclic sesquiterpene synthase
Genes
BDI: 100833760
ATS: 109780592 109783760
TDC: 119356231 119356232 119365401 119365402
TAES: 100873133 123041882 123041883 123054327 123190213 123191849
TUA: 125533918 125539513
LPER: 127336238
LRD: 124679046
SBI: 8072328
ZMA: 100274033 541974
MFLO: 136496751
SITA: 101771563
SVS: 117862601
PVIR: 120640652 120683675
PHAI: 112898865
PAUA: 133925609
 » show all
Reference
PMID:12481088
  Authors
Schnee C, Kollner TG, Gershenzon J, Degenhardt J
  Title
The maize gene terpene synthase 1 encodes a sesquiterpene synthase catalyzing the formation of (E)-beta-farnesene, (E)-nerolidol, and (E,E)-farnesol after herbivore damage.
  Journal
Plant Physiol 130:2049-60 (2002)
DOI:10.1104/pp.008326
  Sequence
[zma:541974]
LinkDB

KEGG   ENZYME: 3.1.7.6
Entry
EC 3.1.7.6                  Enzyme                                 
Name
farnesyl diphosphatase;
FPP phosphatase
Class
Hydrolases;
Acting on ester bonds;
Diphosphoric-monoester hydrolases
Sysname
(2E,6E)-farnesyl-diphosphate diphosphohydrolase
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesol + diphosphate [RN:R08697]
Reaction(KEGG)
R08697
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
(2E,6E)-farnesol [CPD:C01126];
diphosphate [CPD:C00013]
Comment
The enzyme is involved in the biosynthesis of acyclic sesquiterpenoids [1].
History
EC 3.1.7.6 created 2010
Pathway
ec00900  Terpenoid backbone biosynthesis
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K15793  acyclic sesquiterpene synthase
Genes
BDI: 100833760
ATS: 109780592 109783760
TDC: 119356231 119356232 119365401 119365402
TAES: 100873133 123041882 123041883 123054327 123190213 123191849
TUA: 125533918 125539513
LPER: 127336238
LRD: 124679046
SBI: 8072328
ZMA: 100274033 541974
MFLO: 136496751
SITA: 101771563
SVS: 117862601
PVIR: 120640652 120683675
PHAI: 112898865
PAUA: 133925609
 » show all
Reference
1  [PMID:16484724]
  Authors
Song L
  Title
A soluble form of phosphatase in Saccharomyces cerevisiae capable of converting farnesyl diphosphate into E,E-farnesol.
  Journal
Appl Biochem Biotechnol 128:149-58 (2006)
DOI:10.1385/abab:128:2:149
Reference
2  [PMID:4288361]
  Authors
Tsai SC, Gaylor JL.
  Title
Testicular sterols. V. Preparation and partial purification of a microsomal prenol pyrophosphate pyrophosphohydrolase.
  Journal
J Biol Chem 241:4043-50 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.7.6
IUBMB Enzyme Nomenclature: 3.1.7.6
ExPASy - ENZYME nomenclature database: 3.1.7.6
BRENDA, the Enzyme Database: 3.1.7.6
LinkDB

KEGG   REACTION: R08697
Entry
R08697                      Reaction                               
Name
trans,trans-farnesyl-diphosphate diphosphohydrolase;
(2E,6E)-farnesyl-diphosphate diphosphohydrolase
Definition
trans,trans-Farnesyl diphosphate + H2O <=> (2E,6E)-Farnesol + Diphosphate
Equation
C00448 + C00001 <=> C01126 + C00013
Reaction class
RC00017  C00448_C01126
Enzyme
3.1.7.6
Pathway
rn00900  Terpenoid backbone biosynthesis
rn00909  Sesquiterpenoid and triterpenoid biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.1  Acting on ester bonds
   3.1.7  Diphosphoric-monoester hydrolases
    3.1.7.6
     R08697  trans,trans-Farnesyl diphosphate + H2O <=> (2E,6E)-Farnesol + Diphosphate
Orthology
K15793  acyclic sesquiterpene synthase [EC:4.2.3.49 4.2.3.47 3.1.7.6]
LinkDB

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