KEGG   ORTHOLOGY: K15793
Entry
K15793                      KO                                     
Symbol
K15793
Name
acyclic sesquiterpene synthase [EC:4.2.3.49 4.2.3.47 3.1.7.6]
Pathway
map00900  Terpenoid backbone biosynthesis
map00909  Sesquiterpenoid and triterpenoid biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R08695  (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-beta-farnesene-forming]
R08697  trans,trans-farnesyl-diphosphate diphosphohydrolase
R09618  (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(3R,6E)-nerolidol-forming]
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K15793  K15793; acyclic sesquiterpene synthase
   00909 Sesquiterpenoid and triterpenoid biosynthesis
    K15793  K15793; acyclic sesquiterpene synthase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.7  Diphosphoric-monoester hydrolases
    3.1.7.6  farnesyl diphosphatase
     K15793  K15793; acyclic sesquiterpene synthase
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.47  beta-farnesene synthase
     K15793  K15793; acyclic sesquiterpene synthase
    4.2.3.49  (3R,6E)-nerolidol synthase
     K15793  K15793; acyclic sesquiterpene synthase
Genes
BDI: 100833760
ATS: 109780592 109783760
TDC: 119356231 119356232 119365401 119365402
TAES: 100873133 123041882 123041883 123054327 123190213 123191849
TUA: 125533918 125539513
LPER: 127336238
LRD: 124679046
SBI: 8072328
ZMA: 100274033 541974
MFLO: 136496751
SITA: 101771563
SVS: 117862601
PHAI: 112898865
PAUA: 133925609
 » show all
Reference
  Authors
Schnee C, Kollner TG, Gershenzon J, Degenhardt J
  Title
The maize gene terpene synthase 1 encodes a sesquiterpene synthase catalyzing the formation of (E)-beta-farnesene, (E)-nerolidol, and (E,E)-farnesol after herbivore damage.
  Journal
Plant Physiol 130:2049-60 (2002)
DOI:10.1104/pp.008326
  Sequence
[zma:541974]
LinkDB

KEGG   ENZYME: 3.1.7.6
Entry
EC 3.1.7.6                  Enzyme                                 
Name
farnesyl diphosphatase;
FPP phosphatase
Class
Hydrolases;
Acting on ester bonds;
Diphosphoric-monoester hydrolases
Sysname
(2E,6E)-farnesyl-diphosphate diphosphohydrolase
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesol + diphosphate [RN:R08697]
Reaction(KEGG)
R08697
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
(2E,6E)-farnesol [CPD:C01126];
diphosphate [CPD:C00013]
Comment
The enzyme is involved in the biosynthesis of acyclic sesquiterpenoids [1].
History
EC 3.1.7.6 created 2010
Pathway
ec00900  Terpenoid backbone biosynthesis
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K15793  acyclic sesquiterpene synthase
Genes
BDI100833760
ATS109780592 109783760
TDC119356231 119356232 119365401 119365402
TAES100873133 123041882 123041883 123054327 123190213 123191849
TUA125533918 125539513
LPER127336238
LRD124679046
SBI8072328
ZMA100274033 541974
MFLO136496751
SITA101771563
SVS117862601
PVIR120640652 120683675
PHAI112898865
PAUA133925609
 » show all
Reference
1  [PMID:16484724]
  Authors
Song L
  Title
A soluble form of phosphatase in Saccharomyces cerevisiae capable of converting farnesyl diphosphate into E,E-farnesol.
  Journal
Appl Biochem Biotechnol 128:149-58 (2006)
DOI:10.1385/abab:128:2:149
Reference
2  [PMID:4288361]
  Authors
Tsai SC, Gaylor JL.
  Title
Testicular sterols. V. Preparation and partial purification of a microsomal prenol pyrophosphate pyrophosphohydrolase.
  Journal
J Biol Chem 241:4043-50 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.7.6
IUBMB Enzyme Nomenclature: 3.1.7.6
ExPASy - ENZYME nomenclature database: 3.1.7.6
BRENDA, the Enzyme Database: 3.1.7.6
LinkDB

KEGG   REACTION: R08697
Entry
R08697                      Reaction                               
Name
trans,trans-farnesyl-diphosphate diphosphohydrolase;
(2E,6E)-farnesyl-diphosphate diphosphohydrolase
Definition
trans,trans-Farnesyl diphosphate + H2O <=> (2E,6E)-Farnesol + Diphosphate
Equation
Reaction class
RC00017  C00448_C01126
Enzyme
Pathway
rn00900  Terpenoid backbone biosynthesis
rn00909  Sesquiterpenoid and triterpenoid biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.1  Acting on ester bonds
   3.1.7  Diphosphoric-monoester hydrolases
    3.1.7.6
     R08697  trans,trans-Farnesyl diphosphate + H2O <=> (2E,6E)-Farnesol + Diphosphate
Orthology
K15793  acyclic sesquiterpene synthase [EC:4.2.3.49 4.2.3.47 3.1.7.6]
LinkDB

DBGET integrated database retrieval system