KEGG   ORTHOLOGY: K22269
Entry
K22269            Tight     KO                                     

Name
rosA
Definition
8-amino-8-demethylriboflavin N,N-dimethyltransferase [EC:2.1.1.343]
Pathway
ko00997  Biosynthesis of various secondary metabolites - part 3
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00890  Roseoflavin biosynthesis, FMN => roseoflavin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00997 Biosynthesis of various secondary metabolites - part 3
    K22269  rosA; 8-amino-8-demethylriboflavin N,N-dimethyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.343  8-amino-8-demethylriboflavin N,N-dimethyltransferase
     K22269  rosA; 8-amino-8-demethylriboflavin N,N-dimethyltransferase
Other DBs
RN: R11778 R11779 R11780
Genes
SDV: BN159_8032(rosA)
Reference
  Authors
Jankowitsch F, Kuhm C, Kellner R, Kalinowski J, Pelzer S, Macheroux P, Mack M
  Title
A novel N,N-8-amino-8-demethyl-D-riboflavin Dimethyltransferase (RosA) catalyzing the two terminal steps of roseoflavin biosynthesis in Streptomyces davawensis.
  Journal
J Biol Chem 286:38275-85 (2011)
DOI:10.1074/jbc.M111.292300
  Sequence
Reference
  Authors
Tongsook C, Uhl MK, Jankowitsch F, Mack M, Gruber K, Macheroux P
  Title
Structural and kinetic studies on RosA, the enzyme catalysing the methylation of 8-demethyl-8-amino-d-riboflavin to the antibiotic roseoflavin.
  Journal
FEBS J 283:1531-49 (2016)
DOI:10.1111/febs.13690
  Sequence
LinkDB

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