KEGG   NETWORK: N00949
Entry
N00949                      Network                                

Name
Shigella IpaB to NLRC4 Inflammasome signaling pathway
Definition
IpaB -> K+ -> (NLRC4+PYCARD) -> CASP1 -> IL1B
  Expanded
K13285 -> C00238 -> (58484+29108) -> 834 -> 3553
Class
nt06139 NLR signaling (viruses and bacteria)
Type
Pathogen
Pathway
hsa05131  Shigellosis
Disease
H00299  Shigellosis
Gene
58484  NLRC4; NLR family CARD domain containing 4
29108  PYCARD; PYD and CARD domain containing
834  CASP1; caspase 1
3553  IL1B; interleukin 1 beta
Perturbant
K13285 (IpaB)  sipB; invasin B
Metabolite
C00238  Potassium cation
Reference
  Authors
Senerovic L, Tsunoda SP, Goosmann C, Brinkmann V, Zychlinsky A, Meissner F, Kolbe M
  Title
Spontaneous formation of IpaB ion channels in host cell membranes reveals how Shigella induces pyroptosis in macrophages.
  Journal
Cell Death Dis 3:e384 (2012)
DOI:10.1038/cddis.2012.124
Reference
  Authors
Ashida H, Mimuro H, Sasakawa C
  Title
Shigella manipulates host immune responses by delivering effector proteins with specific roles.
  Journal
Front Immunol 6:219 (2015)
DOI:10.3389/fimmu.2015.00219
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