KEGG   Addendum: AAM94794
Entry
AAM94794          CDS       T10000                                 
Symbol
calE8
Name
(KEGG) enediyne polyketide synthase
  KO
K15314  enediyne polyketide synthase
Taxonomy
TAX:1877
  Lineage
Bacteria; Actinomycetota; Actinomycetes; Micromonosporales; Micromonosporaceae; Micromonospora
Organism
Micromonospora echinospora
Module
1877_M00825  10-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 10-membered enediyne core
SSDB
Motif
Pfam: ketoacyl-synt Ketoacyl-synt_C KR Acyl_transf_1 adh_short PS-DH adh_short_C2 PKS_DH_N KAsynt_C_assoc PP-binding Thiolase_N Ser_hydrolase
Other DBs
NCBI-ProteinID: AAM94794
GB: AF497482
UniProt: Q8KNG1
Structure
LinkDB
AA seq 1919 aa
MSRIAVVGLACRFPDAAGPGQLWENALAGRRAFRRLPEERMRAADYWSPDPAAPDRYYAG
NAAVIEGYEFDRVGFKVSGSTYRSTDLTHWLALDMAAQALADAGFPEGDGLPRERTAVVV
GNTLTGEFTRAGMMRLRWPYVRRVVGAALGEQGWDDDRVAAFLADLERSYKAPFAEITED
SLAGGLSNTIAGRICNHFDLHGGGYTVDGACASSLLSVVTACRSLTDLDVDVAVAGGVDL
SIDPFEMVGFAKTGALAGDEMRVYDRRSNGFWPGEGCGMVVLMRERDALAQGRRIYASVA
GWGVSSDGRGGITRPEAAGYRLALRRAYQRAGFGVDTVPLFEGHGTGTAVGDGTELRALG
EERRAADPDADPAAIGSIKGMIGHTKAAAGVAGLIKAVLAVHHQVVPPTVGCVEPHPELA
ADRPALRAVRRAEPWPAGAAQRAGVTAMGFGGINTHLVVDGPTRPRRRSLDRRTQQLARS
VQDAELLLVDADTRDELRDRLDDLRTVVAGLAFAELGDLATNLHRSQRGRAYRAAVVARS
PEEADRALGLAARALAPEGAGTLVDPARGVFVGRVTRPARVGFLFPGQGSGRGWGGGALR
RRFTEIDDVYRAAGEPPGDEAAGSTVFAQPRIVTGSLAGLRALAALDIDATVVVGHSLGE
LTTLHWAGCLDEDELRELVTLRGEAMARHAPPGAMLGVTAGPEETVALLAGTNAVIAGYN
GPRQTVVAGADDIVAEVARRAATAGVNCTRLPVPHAFHSPLMASAAAAFAERLRSRRFGP
LLRRVASTVTGAVLPSDTDLPRHLHRQIEAPVRFAAALGRAAAEVDLFLEVGPGRVLTGL
AREQAPDVPALAVDTDAESLSGLLAAVGAVYALGGPAAYPVLFEDRLTRPFDPHRARTFF
ASPCEAAPELAGPAPAAVAPVPAPARADDTALPAATGALELVRHLVAERAELPVEVLRDD
SRFLDDLHMSSITVGQLVNEAARAMGLSAVAMPTNFATATVREMAEALEAREREAPHERA
DLVAGVAPWVRTFVVDLVDEPLPATDPTEPCGRWQVFAGADHPLADALRRALEAAGVGEG
VLVCLPDEPDEEHLVTAVRGAQAALRQPPGGRLVVVQPAARAGALAKTARLEGDRLRTTV
VTTPLDPAAVDRVVADVAATDDFTEAVYDPGGRRRVPVLRPLPASDGEPGALPLGPADVL
LVTGGGKGITAESALMLARESGARLAVLGRSDPTADEALADNLKRLADAASDLRYLRVDV
TDAGAVAAAVATVTADWGPVTAVLHGAGQNTPAALADLDEAALRGVFAAKVDGLRAVLAA
VDPARLRLLVTFGSIIGRAGLHGEAHYAAANEALAELTREVAATRPECRAVCLEWSVWSG
VGMGERLSVVESLSGSGVTPISPDDGLRVLREVVADDTLPPVVVVTGRTGGVETLRYHRS
ELPLLRFTERPLVRYDGIELVCEVDLARTTDPYLEDHRLDGDLLFPAVLGLEAMAQVATA
LARHPGVPVIEEVRFDRPVVVDPDTGTTVRVAALVRSEQVIDVVLRSAVTGFAADHFRAR
LRFAPDETYPAYTAAPAPAELPAVPLDPARDLYGDVLFQAGRFRRIKGYRQVAARVAEAE
VVTSDAASWFSAFLPGRLVLGDPGARDAFMHGIQVCVPDATLLPEGIDRIWSAGPKLSAT
EAVTMTAREREQHGTAYVYDVVVRDATGAVIEHWMGLRLRAVRPHAPRGSWPPALLGPLL
QRRLAEVFPGDIAVAAAPGGGPRDSGALLSRALGQPVVVRHRPDGRPEVDLPYTVSVAHS
APLDLAVAGDGTLACDAEPVAARPADVRRDLVGRHGAVAALLVAEVGDPPDVAATRVWCA
EECLQKAGRPEGRLTLLPGALPDGWVVLDAGDVRVATRVVAVAGAAAPAVVAVLSGAGR
Reference
PMID:12183629
  Authors
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS
  Title
The calicheamicin gene cluster and its iterative type I enediyne PKS.
  Journal
Science 297:1173-6 (2002)
DOI:10.1126/science.1072105

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