KEGG   Delphinapterus leucas (beluga whale): 111182833
Entry
111182833         CDS       T05885                                 

Gene name
GRB2
Definition
(RefSeq) growth factor receptor-bound protein 2
  KO
K04364  growth factor receptor-bound protein 2
Organism
dle  Delphinapterus leucas (beluga whale)
Pathway
dle01521  EGFR tyrosine kinase inhibitor resistance
dle01522  Endocrine resistance
dle04010  MAPK signaling pathway
dle04012  ErbB signaling pathway
dle04014  Ras signaling pathway
dle04062  Chemokine signaling pathway
dle04068  FoxO signaling pathway
dle04072  Phospholipase D signaling pathway
dle04150  mTOR signaling pathway
dle04151  PI3K-Akt signaling pathway
dle04380  Osteoclast differentiation
dle04510  Focal adhesion
dle04540  Gap junction
dle04550  Signaling pathways regulating pluripotency of stem cells
dle04630  JAK-STAT signaling pathway
dle04650  Natural killer cell mediated cytotoxicity
dle04660  T cell receptor signaling pathway
dle04662  B cell receptor signaling pathway
dle04664  Fc epsilon RI signaling pathway
dle04714  Thermogenesis
dle04722  Neurotrophin signaling pathway
dle04910  Insulin signaling pathway
dle04912  GnRH signaling pathway
dle04915  Estrogen signaling pathway
dle04917  Prolactin signaling pathway
dle04926  Relaxin signaling pathway
dle04935  Growth hormone synthesis, secretion and action
dle05034  Alcoholism
dle05160  Hepatitis C
dle05161  Hepatitis B
dle05163  Human cytomegalovirus infection
dle05165  Human papillomavirus infection
dle05200  Pathways in cancer
dle05203  Viral carcinogenesis
dle05205  Proteoglycans in cancer
dle05206  MicroRNAs in cancer
dle05210  Colorectal cancer
dle05211  Renal cell carcinoma
dle05213  Endometrial cancer
dle05214  Glioma
dle05215  Prostate cancer
dle05220  Chronic myeloid leukemia
dle05221  Acute myeloid leukemia
dle05223  Non-small cell lung cancer
dle05224  Breast cancer
dle05225  Hepatocellular carcinoma
dle05226  Gastric cancer
dle05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:dle00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    111182833 (GRB2)
   04012 ErbB signaling pathway
    111182833 (GRB2)
   04014 Ras signaling pathway
    111182833 (GRB2)
   04630 JAK-STAT signaling pathway
    111182833 (GRB2)
   04068 FoxO signaling pathway
    111182833 (GRB2)
   04072 Phospholipase D signaling pathway
    111182833 (GRB2)
   04151 PI3K-Akt signaling pathway
    111182833 (GRB2)
   04150 mTOR signaling pathway
    111182833 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    111182833 (GRB2)
   04540 Gap junction
    111182833 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    111182833 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    111182833 (GRB2)
   04660 T cell receptor signaling pathway
    111182833 (GRB2)
   04662 B cell receptor signaling pathway
    111182833 (GRB2)
   04664 Fc epsilon RI signaling pathway
    111182833 (GRB2)
   04062 Chemokine signaling pathway
    111182833 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    111182833 (GRB2)
   04912 GnRH signaling pathway
    111182833 (GRB2)
   04915 Estrogen signaling pathway
    111182833 (GRB2)
   04917 Prolactin signaling pathway
    111182833 (GRB2)
   04926 Relaxin signaling pathway
    111182833 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    111182833 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    111182833 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    111182833 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    111182833 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    111182833 (GRB2)
   05206 MicroRNAs in cancer
    111182833 (GRB2)
   05205 Proteoglycans in cancer
    111182833 (GRB2)
   05203 Viral carcinogenesis
    111182833 (GRB2)
   05231 Choline metabolism in cancer
    111182833 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    111182833 (GRB2)
   05225 Hepatocellular carcinoma
    111182833 (GRB2)
   05226 Gastric cancer
    111182833 (GRB2)
   05214 Glioma
    111182833 (GRB2)
   05221 Acute myeloid leukemia
    111182833 (GRB2)
   05220 Chronic myeloid leukemia
    111182833 (GRB2)
   05211 Renal cell carcinoma
    111182833 (GRB2)
   05215 Prostate cancer
    111182833 (GRB2)
   05213 Endometrial cancer
    111182833 (GRB2)
   05224 Breast cancer
    111182833 (GRB2)
   05223 Non-small cell lung cancer
    111182833 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    111182833 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    111182833 (GRB2)
   05160 Hepatitis C
    111182833 (GRB2)
   05163 Human cytomegalovirus infection
    111182833 (GRB2)
   05165 Human papillomavirus infection
    111182833 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    111182833 (GRB2)
   01522 Endocrine resistance
    111182833 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:dle04131]
    111182833 (GRB2)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:dle04990]
    111182833 (GRB2)
Membrane trafficking [BR:dle04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    111182833 (GRB2)
Domain-containing proteins not elsewhere classified [BR:dle04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   111182833 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 111182833
NCBI-ProteinID: XP_022445340
UniProt: A0A2Y9PJ90
LinkDB
Position
Unknown
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagccaccgcagacgacgagctgagcttcaaa
aggggggacatcctcaaggttttgaatgaagaatgtgatcagaactggtacaaggcagag
ctcaatgggaaagacggcttcatccccaagaattacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgcttagcaaacagcggcacgat
ggggcctttcttatccgagagagcgagagtgctcctggggatttctccctctctgtcaag
tttggaaatgatgtacagcacttcaaggtgctccgagatggggctggaaagtatttcctc
tgggtggtcaagttcaattctttgaatgagctggtagattatcacagatctacatccgtc
tccagaaaccagcagatatttctccgggacatagagcaggtgccacagcaaccgacgtac
gtccaagccctctttgactttgatccccaagaggatggagagctgggattccgtcgggga
gactttatccacgtcatggataactcagaccccaactggtggaaaggggcttgccacggg
cagaccggcatgtttccacgcaattacgtcacccccgtgaaccggaacgtctaa

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