KEGG   ORTHOLOGY: K04364
Entry
K04364                      KO                                     

Symbol
GRB2
Name
growth factor receptor-bound protein 2
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04013  MAPK signaling pathway - fly
map04014  Ras signaling pathway
map04062  Chemokine signaling pathway
map04068  FoxO signaling pathway
map04072  Phospholipase D signaling pathway
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04320  Dorso-ventral axis formation
map04380  Osteoclast differentiation
map04510  Focal adhesion
map04540  Gap junction
map04550  Signaling pathways regulating pluripotency of stem cells
map04630  JAK-STAT signaling pathway
map04650  Natural killer cell mediated cytotoxicity
map04660  T cell receptor signaling pathway
map04662  B cell receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map04714  Thermogenesis
map04722  Neurotrophin signaling pathway
map04910  Insulin signaling pathway
map04912  GnRH signaling pathway
map04915  Estrogen signaling pathway
map04917  Prolactin signaling pathway
map04926  Relaxin signaling pathway
map04935  Growth hormone synthesis, secretion and action
map05034  Alcoholism
map05160  Hepatitis C
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05165  Human papillomavirus infection
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05210  Colorectal cancer
map05211  Renal cell carcinoma
map05213  Endometrial cancer
map05214  Glioma
map05215  Prostate cancer
map05220  Chronic myeloid leukemia
map05221  Acute myeloid leukemia
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04013 MAPK signaling pathway - fly
    K04364  GRB2; growth factor receptor-bound protein 2
   04012 ErbB signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04014 Ras signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04630 JAK-STAT signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04068 FoxO signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04072 Phospholipase D signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04151 PI3K-Akt signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04150 mTOR signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04364  GRB2; growth factor receptor-bound protein 2
   04540 Gap junction
    K04364  GRB2; growth factor receptor-bound protein 2
   04550 Signaling pathways regulating pluripotency of stem cells
    K04364  GRB2; growth factor receptor-bound protein 2
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04364  GRB2; growth factor receptor-bound protein 2
   04660 T cell receptor signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04662 B cell receptor signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04664 Fc epsilon RI signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04062 Chemokine signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
  09152 Endocrine system
   04910 Insulin signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04912 GnRH signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04915 Estrogen signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04917 Prolactin signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04926 Relaxin signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
   04935 Growth hormone synthesis, secretion and action
    K04364  GRB2; growth factor receptor-bound protein 2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04364  GRB2; growth factor receptor-bound protein 2
  09158 Development and regeneration
   04320 Dorso-ventral axis formation
    K04364  GRB2; growth factor receptor-bound protein 2
   04380 Osteoclast differentiation
    K04364  GRB2; growth factor receptor-bound protein 2
  09159 Environmental adaptation
   04714 Thermogenesis
    K04364  GRB2; growth factor receptor-bound protein 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04364  GRB2; growth factor receptor-bound protein 2
   05206 MicroRNAs in cancer
    K04364  GRB2; growth factor receptor-bound protein 2
   05205 Proteoglycans in cancer
    K04364  GRB2; growth factor receptor-bound protein 2
   05207 Chemical carcinogenesis - receptor activation
    K04364  GRB2; growth factor receptor-bound protein 2
   05208 Chemical carcinogenesis - reactive oxygen species
    K04364  GRB2; growth factor receptor-bound protein 2
   05203 Viral carcinogenesis
    K04364  GRB2; growth factor receptor-bound protein 2
   05231 Choline metabolism in cancer
    K04364  GRB2; growth factor receptor-bound protein 2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04364  GRB2; growth factor receptor-bound protein 2
   05225 Hepatocellular carcinoma
    K04364  GRB2; growth factor receptor-bound protein 2
   05226 Gastric cancer
    K04364  GRB2; growth factor receptor-bound protein 2
   05214 Glioma
    K04364  GRB2; growth factor receptor-bound protein 2
   05221 Acute myeloid leukemia
    K04364  GRB2; growth factor receptor-bound protein 2
   05220 Chronic myeloid leukemia
    K04364  GRB2; growth factor receptor-bound protein 2
   05211 Renal cell carcinoma
    K04364  GRB2; growth factor receptor-bound protein 2
   05215 Prostate cancer
    K04364  GRB2; growth factor receptor-bound protein 2
   05213 Endometrial cancer
    K04364  GRB2; growth factor receptor-bound protein 2
   05224 Breast cancer
    K04364  GRB2; growth factor receptor-bound protein 2
   05223 Non-small cell lung cancer
    K04364  GRB2; growth factor receptor-bound protein 2
  09172 Infectious disease: viral
   05161 Hepatitis B
    K04364  GRB2; growth factor receptor-bound protein 2
   05160 Hepatitis C
    K04364  GRB2; growth factor receptor-bound protein 2
   05163 Human cytomegalovirus infection
    K04364  GRB2; growth factor receptor-bound protein 2
   05165 Human papillomavirus infection
    K04364  GRB2; growth factor receptor-bound protein 2
  09165 Substance dependence
   05034 Alcoholism
    K04364  GRB2; growth factor receptor-bound protein 2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04364  GRB2; growth factor receptor-bound protein 2
   01522 Endocrine resistance
    K04364  GRB2; growth factor receptor-bound protein 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04364  GRB2; growth factor receptor-bound protein 2
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    K04364  GRB2; growth factor receptor-bound protein 2
Other DBs
GO: 0005070 0005154
Genes
HSA: 2885(GRB2)
PTR: 737245(GRB2)
PPS: 100993451(GRB2)
GGO: 101133976(GRB2)
PON: 100173972(GRB2)
NLE: 100588468(GRB2)
MCC: 702041(GRB2)
MCF: 102118276(GRB2)
CSAB: 103243048(GRB2)
CATY: 105577731(GRB2)
PANU: 101002675(GRB2)
RRO: 104681311(GRB2)
RBB: 108537414(GRB2)
TFN: 117066678(GRB2)
PTEH: 111542428(GRB2)
CJC: 100395682(GRB2)
SBQ: 101038666(GRB2)
MMUR: 105878936(GRB2)
MMU: 14784(Grb2)
MCAL: 110304772(Grb2)
MPAH: 110331195(Grb2)
RNO: 81504(Grb2)
MCOC: 116076719(Grb2)
MUN: 110547825(Grb2)
CGE: 100769627(Grb2)
PLEU: 114707024(Grb2)
NGI: 103732729(Grb2)
HGL: 101717035(Grb2)
CCAN: 109681589(Grb2)
OCU: 100342500(GRB2)
OPI: 101531037(GRB2)
TUP: 102493080(GRB2)
CFA: 483312(GRB2)
VVP: 112920790(GRB2)
VLG: 121473934(GRB2)
AML: 100468916(GRB2)
UMR: 103665736(GRB2)
UAH: 113244637(GRB2)
ORO: 101362094(GRB2)
ELK: 111160411
MPUF: 101685370(GRB2)
EJU: 114216301(GRB2)
MLX: 118024273(GRB2)
FCA: 101099916(GRB2)
PYU: 121017912(GRB2)
PBG: 122485897(GRB2)
PTG: 102970459(GRB2)
PPAD: 109276940(GRB2)
AJU: 106987795(GRB2)
HHV: 120228194(GRB2)
BTA: 535298(GRB2)
BOM: 102286241(GRB2)
BIU: 109574040(GRB2)
BBUB: 102394713(GRB2)
CHX: 102170356(GRB2)
OAS: 101109893(GRB2) 114110058
ODA: 120866765(GRB2)
CCAD: 122436698(GRB2)
SSC: 100192436(GRB2)
CFR: 102515306(GRB2)
CBAI: 105065653(GRB2)
CDK: 105104642(GRB2)
BACU: 103010512(GRB2)
LVE: 103079766(GRB2)
OOR: 101271441(GRB2)
DLE: 111182833(GRB2)
PCAD: 114483947(GRB2)
ECB: 100051866(GRB2)
EPZ: 103546580(GRB2)
EAI: 106830292(GRB2)
MYB: 102241832(GRB2)
MYD: 102754991(GRB2)
MMYO: 118671153(GRB2)
MNA: 107536618(GRB2)
PKL: 118704441(GRB2)
HAI: 109383688(GRB2)
DRO: 112298645(GRB2)
SHON: 119000762(GRB2)
AJM: 119058521(GRB2)
MMF: 118633806(GRB2)
PALE: 102878822(GRB2)
PGIG: 120600272(GRB2)
RAY: 107503781(GRB2)
TOD: 119232938(GRB2)
LAV: 100655474(GRB2)
TMU: 101359012
MDO: 100022894(GRB2)
GAS: 123245523(GRB2)
SHR: 100928380(GRB2)
PCW: 110219266(GRB2)
OAA: 100075806(GRB2)
GGA: 386572(GRB2)
PCOC: 116232358(GRB2)
MGP: 100541322(GRB2)
CJO: 107322339(GRB2)
NMEL: 110407421(GRB2)
APLA: 101797458(GRB2)
ACYG: 106034739(GRB2)
TGU: 100190285(GRB2)
LSR: 110484064(GRB2)
SCAN: 103819847(GRB2)
PMOA: 120505569(GRB2)
OTC: 121338247(GRB2)
PRUF: 121363830(GRB2)
GFR: 102038068(GRB2)
FAB: 101812321(GRB2)
PHI: 102101539(GRB2)
PMAJ: 107212507(GRB2)
CCAE: 111937316(GRB2)
CCW: 104694312(GRB2)
ETL: 114063378(GRB2)
FPG: 101913969(GRB2)
FCH: 102057209(GRB2)
CLV: 102098952(GRB2)
EGZ: 104125396(GRB2)
NNI: 104020665(GRB2)
ACUN: 113486738(GRB2)
PADL: 103916707(GRB2)
AAM: 106485676(GRB2)
AROW: 112977701(GRB2)
NPD: 112953666(GRB2)
DNE: 112982520(GRB2)
ASN: 102376596(GRB2)
AMJ: 102564907(GRB2)
CPOO: 109315065(GRB2)
GGN: 109298035(GRB2)
PSS: 102463609(GRB2)
CMY: 102945306(GRB2)
CPIC: 101937357(GRB2)
TST: 117887352(GRB2)
CABI: 116832265(GRB2)
ACS: 100564375(grb2)
PVT: 110085805(GRB2)
PBI: 103062398(GRB2)
PMUR: 107292723(GRB2)
TSR: 106553913(GRB2)
PGUT: 117660512(GRB2)
VKO: 123035461(GRB2)
PMUA: 114590607
ZVI: 118079827(GRB2) 118082777
GJA: 107110018(GRB2)
XLA: 399458(grb2.L) 444095(grb2.S)
XTR: 493492(grb2)
NPR: 108791159(GRB2)
DRE: 406308(grb2b) 493609(grb2a)
IPU: 100528114(grb2) 108256494
PHYP: 113524560 113528201(grb2)
TRU: 101061204 101070656(grb2)
LCO: 104929435(grb2)
CGOB: 115012209
ELY: 117268541(grb2b)
PLEP: 121942232 121956174(grb2b)
SLUC: 116065469(grb2b)
ECRA: 117957842(grb2b)
PFLV: 114570079(grb2)
GAT: 120827679(grb2b)
PPUG: 119219897(grb2b)
MSAM: 119883760(grb2b)
CUD: 121503720(grb2b)
MZE: 101467818(grb2) 101477192
ONL: 100707796 100711914(grb2)
OAU: 116314310 116327142(grb2b)
OLA: 101160816(grb2)
OML: 112146681(grb2b)
XMA: 102231736(grb2)
XCO: 114160045(grb2)
XHE: 116735644(grb2)
PRET: 103468398(grb2)
CVG: 107093104(grb2)
CTUL: 119797283(grb2b)
NFU: 107376249(grb2)
KMR: 108236256(grb2b)
ALIM: 106523871
AOCE: 111567912(grb2)
CSEM: 103393705(grb2)
POV: 109641399(grb2)
LCF: 108898666(grb2)
SDU: 111238087(grb2)
SLAL: 111673746(grb2)
XGL: 120788168(grb2b)
HCQ: 109508473(grb2)
BPEC: 110155075(grb2)
MALB: 109973503(grb2)
SFM: 108937443(grb2) 108939904
PKI: 111833563 111834215(grb2)
LOC: 102696581(grb2)
LCM: 102353904(GRB2)
CMK: 103175438(grb2a)
RTP: 109933522(grb2)
BFO: 118428890
BBEL: 109483807
DME: Dmel_CG6033(drk)
DER: 6549549
DSI: Dsimw501_GD25755(Dsim_drk)
DSR: 110184783
DPE: 6592753
DWI: 6637889
DGR: 6569027
DAZ: 108615062
DNV: 108653840
DHE: 111599694
CCAT: 101449381
BOD: 106614467
MDE: 101896778
SCAC: 106088371
LCQ: 111677404
ACOZ: 120955710
AARA: 120901011
AAG: 5564363
CPII: 120430841
AME: 550857
ACER: 107995601
BIM: 100748502
BBIF: 117217251
BVK: 117243291
BVAN: 117155177
BTER: 100650501
CCAL: 108627710
OBB: 114873340
MGEN: 117222939
NMEA: 116429019
CGIG: 122402189
SOC: 105194465
MPHA: 105836050
AEC: 105148473
ACEP: 105619053
PBAR: 105428079
VEM: 105570368
HST: 105181508
DQU: 106749264
CFO: 105251887
FEX: 115236298
LHU: 105670624
PGC: 109851629
OBO: 105275755
PCF: 106790925
PFUC: 122523293
NVI: 100115944
CSOL: 105362095
TPRE: 106657837
MDL: 103569461
FAS: 105266232
DAM: 107046231
CCIN: 107265650
TCA: 658522
DPA: 109538190
ATD: 109608829
AGB: 108907261
LDC: 111507805
NVL: 108561287
APLN: 108737266
PPYR: 116179776
OTU: 111421423
BMOR: 100862763(DRK)
BMAN: 114253365
BANY: 112049681
PMAC: 106718231
PPOT: 106107200
PXU: 106118975
PRAP: 110992781
ZCE: 119832686
HAW: 110371319
TNL: 113492015
PXY: 105385555
API: 100169346
DNX: 107166700
RMD: 113551873
BTAB: 109031773
CLEC: 106663478
HHAL: 106682481
NLU: 111044882
FOC: 113208827
ZNE: 110836794
CSEC: 111861232
FCD: 110852988
DMK: 116930439
PVM: 113817579
PJA: 122262904
HAME: 121870508
HAZT: 108669408
EAF: 111702094
DSV: 119453442
RSAN: 119399711
RMP: 119180065
VDE: 111251671
VJA: 111260399
TUT: 107362328
DPTE: 113790769
CEL: CELE_C14F5.5(sem-5)
CBR: CBG16856(Cbr-sem-5) CBG23363
BMY: BM_BM2205(Bma-sem-5)
TSP: Tsp_07994
CRG: 105329475
HMG: 100199343
 » show all
Reference
PMID:7689150
  Authors
Suen KL, Bustelo XR, Pawson T, Barbacid M
  Title
Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.
  Journal
Mol Cell Biol 13:5500-12 (1993)
DOI:10.1128/MCB.13.9.5500
  Sequence
[mmu:14784]
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