| Entry |
|
|---|
| Name |
Fentanyl (JAN/USP/INN);
Duragesic (TN);
Subsys (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C22H28N2O
|
|---|
| Exact mass |
336.2202
|
|---|
| Mol weight |
336.47
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG02030 Anesthetics
DG02027 General anesthetics
DG02026 Opioid anesthetics
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
Analgesic
DG01984 Opioid analgesics
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 8219 |
| Product (DG00791): | D00320<JP/US> D01399<JP/US> |
|
|---|
| Efficacy |
Analgesic (narcotic), Opioid receptor agonist |
|---|
| Comment |
synthetic-opioid
Phenylpiperidine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N01 ANESTHETICS
N01A ANESTHETICS, GENERAL
N01AH Opioid anesthetics
N01AH01 Fentanyl
D00320 Fentanyl (JAN/USP/INN) <JP/US>
N02 ANALGESICS
N02A OPIOIDS
N02AB Phenylpiperidine derivatives
N02AB03 Fentanyl
D00320 Fentanyl (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Analgesics
Opioid Analgesics, Long-acting
Fentanyl
D00320 Fentanyl (JAN/USP/INN)
Opioid Analgesics, Short-acting
Fentanyl
D00320 Fentanyl (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
8 Narcotics
82 Non-alkaloidal narcotics
821 Synthetic narcotics
8219 Others
D00320 Fentanyl (JAN/USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG02030 Anesthetics
DG02027 General anesthetics
DG02026 Opioid anesthetics
DG00791 Fentanyl
D00320 Fentanyl
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00791 Fentanyl
D00320 Fentanyl
Analgesic
DG01984 Opioid analgesics
DG00791 Fentanyl
D00320 Fentanyl
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00791 Fentanyl
D00320 Fentanyl
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D00320 Fentanyl (JAN/USP/INN) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00320
Narcotics and psychotropics in Japan [br08308.html]
Narcotics by Cabinet Order Article 1 (163 substances)
D00320
Drug groups [BR:br08330]
Neuropsychiatric agent
DG02030 Anesthetics
DG02027 General anesthetics
DG02026 Opioid anesthetics
DG00791 Fentanyl
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG00791 Fentanyl
Analgesic
DG01984 Opioid analgesics
DG00791 Fentanyl
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00791 Fentanyl
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 25
1 N1c N 28.2800 -14.2100
2 C1y C 29.5400 -14.9100
3 C8y C 27.0900 -14.9100
4 C5a C 28.2800 -12.8100
5 C1x C 29.5400 -16.3100
6 C1x C 30.7300 -14.2100
7 C8x C 25.9000 -14.2100
8 C8x C 27.0900 -16.3100
9 C1b C 29.5400 -12.1100
10 O5a O 27.0900 -12.1100
11 C1x C 30.7300 -17.0100
12 C1x C 31.9200 -14.9100
13 C8x C 24.6400 -14.9100
14 C8x C 25.8300 -17.0100
15 C1a C 30.7300 -12.8100
16 N1y N 31.9200 -16.3100
17 C8x C 24.6400 -16.2400
18 C1b C 33.1800 -17.0100
19 C1b C 34.3700 -16.3100
20 C8y C 35.5600 -17.0100
21 C8x C 35.5600 -18.4100
22 C8x C 36.8200 -16.3100
23 C8x C 36.8200 -19.1100
24 C8x C 38.0100 -17.0100
25 C8x C 38.0100 -18.4100
BOND 27
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 4 10 2
10 5 11 1
11 6 12 1
12 7 13 1
13 8 14 2
14 9 15 1
15 11 16 1
16 13 17 2
17 16 18 1
18 18 19 1
19 19 20 1
20 20 21 1
21 20 22 2
22 21 23 2
23 22 24 1
24 23 25 1
25 12 16 1
26 14 17 1
27 24 25 2
|
|---|
