KEGG   DRUG: Sumatriptan succinateHelp
Entry
D00676                      Drug                                   

Name
Sumatriptan succinate (JAN/USAN);
Alsuma (TN);
Imitrex (TN);
Sumave dosepro (TN);
Zecutity (TN)
Product
  Generic
SUMATRIPTAN (A-S Medication Solutions), SUMATRIPTAN (A-S Medication Solutions), SUMATRIPTAN (AuroMedics Pharma LLC), SUMATRIPTAN (AuroMedics Pharma LLC), IMITREX (DIRECTRX), SUMATRIPTAN (Golden State Medical Supply), SUMATRIPTAN (Mylan Institutional LLC), SUMATRIPTAN (Mylan Institutional LLC), SUMATRIPTAN (Northstar Rx LLC), SUMATRIPTAN (Proficient Rx LP), SUMATRIPTAN (Proficient Rx LP), SUMATRIPTAN (Ranbaxy Pharmaceuticals), SUMATRIPTAN (Unit Dose Services), SUMATRIPTAN (Unit Dose Services), SUMATRIPTAN (West-Ward Pharmaceuticals Corp), SUMATRIPTAN SUCCINATE (A-S Medication Solutions), SUMATRIPTAN (A-S Medication Solutions), SUMATRIPTAN (Aidarex Pharmaceuticals LLC), SUMATRIPTAN SUCCINATE (Aidarex Pharmaceuticals LLC), SUMATRIPTAN (Aurobindo Pharma Limited), SUMATRIPTAN (Aurobindo Pharma Limited), SUMATRIPTAN (Bryant Ranch Prepack), SUMATRIPTAN SUCCINATE (Carilion Materials Management), SUMATRIPTAN SUCCINATE (Dispensing Solutions), SUMATRIPTAN SUCCINATE (Dr. Reddy's Laboratories Limited), SUMATRIPTAN SUCCINATE (Dr. Reddy's Laboratories Limited), SUMATRIPTAN SUCCINATE (Fresenius Kabi USA), SUMATRIPTAN SUCCINATE (GSMS), SUMATRIPTAN (Golden State Medical Supply), SUMATRIPTAN SUCCINATE (H.J. Harkins Company), SUMATRIPTAN SUCCINATE (JHP Pharmaceuticals LLC), SUMATRIPTAN SUCCINATE (Lake Erie Medical DBA Quality Care Products LLC), SUMATRIPTAN SUCCINATE (Lake Erie Medical DBA Quality Care Products LLC), SUMATRIPTAN SUCCINATE (Lake Erie Medical DBA Quality Care Products LLC), SUMATRIPTAN SUCCINATE (Lake Erie Medical DBA Quality Care Products LLC), SUMATRIPTAN SUCCINATE (MedVantx), SUMATRIPTAN SUCCINATE (Medsource Pharmaceuticals), SUMATRIPTAN SUCCINATE (Mylan Pharmaceuticals), SUMATRIPTAN (NorthStar Rx LLC), SUMATRIPTAN (NuCare Pharmaceuticals), SUMATRIPTAN SUCCINATE (NuCare Pharmaceuticals), SUMATRIPTAN SUCCINATE (NuCare Pharmaceuticals), SUMATRIPTAN (NuCare Pharmaceuticals), SUMATRIPTAN SUCCINATE (Preferred Pharmaceuticals), SUMATRIPTAN (Preferred Pharmaceuticals), SUMATRIPTAN (Preferred Pharmaceuticals), SUMATRIPTAN (Preferred Pharmaceuticals), SUMATRIPTAN (Proficient Rx LP), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN (Proficient Rx LP), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN (Proficient Rx LP), SUMATRIPTAN (Quality Care Products), SUMATRIPTAN SUCCINATE (REMEDYREPACK), SUMATRIPTAN (REMEDYREPACK), SUMATRIPTAN (REMEDYREPACK), SUMATRIPTAN (RPK Pharmaceuticals), SUMATRIPTAN SUCCINATE (RPK Pharmaceuticals), SUMATRIPTAN SUCCINATE (Rebel Distributors Corp), SUMATRIPTAN SUCCINATE (Rebel Distributors Corp), SUMATRIPTAN SUCCINATE (Sun Pharmaceutical Industries), SUMATRIPTAN SUCCINATE (Sun Pharmaceutical Industries), SUMATRIPTAN SUCCINATE (Teva Parenteral Medicines), SUMATRIPTAN (Teva Pharmaceuticals USA), SUMATRIPTAN (Unit Dose Services), SUMATRIPTAN SUCCINATE (Wockhardt Limited), SUMATRIPTAN SUCCINATE (Wockhardt USA LLC.), SUMATRIPTAN (DIRECT RX), SUMATRIPTAN (NuCare Pharmaceuticals)
Formula
C14H21N3O2S. C4H6O4
Exact mass
413.1621
Mol weight
413.4885
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Analgesic
 DG01484  5-HT1B-receptor agonist
 DG01485  5-HT1D-receptor agonist
 DG01518  5-HT1B/1D-receptor agonist
 DG01943  Triptan
Metabolizing enzyme substrate
 DG02917  MAO substrate
Remark
Therapeutic category: 2160
ATC code: N02CC01
Chemical structure group: DG00836
Product (DG00836): D00451<JP/US> D00676<JP/US>
Product (mixture): D11577<US>
Efficacy
Antimigraine, Vasoconstrictor, Serotonin receptor agonist
  Disease
Cluster headache [DS:H01588]
Comment
Triptans
Target
HTR1B [HSA:3351] [KO:K04153]
HTR1D [HSA:3352] [KO:K04153]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: MAOA [HSA:4128]
Interaction
Drug interaction
Structure map
map07048  Antimigraines
map07211  Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CC Selective serotonin (5HT1) agonists
     N02CC01 Sumatriptan
      D00676  Sumatriptan succinate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Antimigraine Agents
  Serotonin (5-HT) 1b/1d Receptor Agonists
   Sumatriptan
    D00676  Sumatriptan succinate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   216  Vasoconstrictors
    2160  Vasoconstrictors
     D00676  Sumatriptan succinate (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR1B
     D00676  Sumatriptan succinate (JAN/USAN) <JP/US>
    HTR1D
     D00676  Sumatriptan succinate (JAN/USAN) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00676
BRITE hierarchy
Other DBs
CAS: 103628-48-4
PubChem: 7847742
ChEBI: 64359
ChEMBL: CHEMBL1201150
DrugBank: DB00669
LigandBox: D00676
NIKKAJI: J528.534H
LinkDB All DBs
KCF data Show

ATOM        28
            1   C8y C    23.6794  -17.9951
            2   C8y C    23.6853  -19.3996
            3   C8y C    25.0140  -17.5639
            4   C8x C    22.4731  -17.2843
            5   N4x N    25.0197  -19.8250
            6   C8x C    22.4673  -20.0930
            7   C8x C    25.8357  -18.6886
            8   C1b C    25.3287  -16.1944
            9   C8y C    21.2553  -17.9893
            10  C8x C    21.2610  -19.3937
            11  C1b C    26.6633  -15.7807
            12  C1b C    20.0373  -17.2957
            13  N1c N    26.9720  -14.4170
            14  S4a S    18.8310  -18.0010
            15  C1a C    28.3066  -14.0033
            16  C1a C    25.9464  -13.4671
            17  N1b N    17.6247  -17.3017
            18  O3c O    19.8217  -19.0033
            19  O3c O    17.8344  -19.0033
            20  C1a C    16.4124  -18.0067
            21  C1b C    30.7583  -18.8477
            22  C1b C    31.9646  -18.1484
            23  C6a C    29.5461  -18.1543
            24  C6a C    33.1767  -18.8420
            25  O6a O    28.3397  -18.8536
            26  O6a O    29.5461  -16.7557
            27  O6a O    34.3889  -18.1426
            28  O6a O    33.1767  -20.2406
BOND        28
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     6  10 1
            10    8  11 1
            11    9  12 1
            12   11  13 1
            13   12  14 1
            14   13  15 1
            15   13  16 1
            16   14  17 1
            17   14  18 2
            18   14  19 2
            19   17  20 1
            20    5   7 1
            21    9  10 2
            22   21  22 1
            23   21  23 1
            24   22  24 1
            25   23  25 1
            26   23  26 2
            27   24  27 1
            28   24  28 2

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