KEGG T01001: 3351

Homo sapiens (human): 3351

Entry

3351              CDS       T01001

Symbol

HTR1B, 5-HT-1B, 5-HT-1D-beta, 5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12

Name

(RefSeq) 5-hydroxytryptamine receptor 1B

K04153

5-hydroxytryptamine receptor 1

Organism

hsa Homo sapiens (human)

Pathway

hsa04024

cAMP signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04082

Neuroactive ligand signaling

hsa04726

Serotonergic synapse

hsa04742

Taste transduction

Network

nt06544 Neuroactive ligand signaling

Element

N01901

Serotonin-HTR1/5-GNAI/O signaling pathway

Drug target

Almotriptan (DG00839):

D02824 D02825<US>

Alniditan dihydrochloride:

D02826

Avitriptan fumarate:

D03014

Cinitapride (DG01520):

D07700 D07701

Cyproheptadine (DG01109):

D02234<JP/US> D07765

Dihydroergotamine (DG00833):

D02211<US> D07837 D07838

Eletriptan (DG00840):

D01973<JP/US> D07887 D11617

Elzasonan (DG01314):

D03982 D03983

Ergot alkaloids:

D07906

Ergotamine (DG00834):

D00679<US>

Frovatriptan (DG00841):

D04264<US> D07997

Indorenate hydrochloride:

D04533

Naratriptan (DG00837):

D00674<JP/US> D08255

Pizotifen (DG00842):

D05523 D08397

Rizatriptan (DG00838):

D00675<JP/US> D05740 D08485

Sumatriptan (DG00836):

D00451<JP/US> D00676<JP/US>

Zolmitriptan:

D00415<JP/US>

Zotepine:

D01321<JP>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    3351 (HTR1B)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    3351 (HTR1B)
   04082 Neuroactive ligand signaling
    3351 (HTR1B)
09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    3351 (HTR1B)
  09157 Sensory system
   04742 Taste transduction
    3351 (HTR1B)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    3351 (HTR1B)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Serotonin
    3351 (HTR1B)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

6:complement(77460924..77463491)

AA seq 390 aa
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALIT
LATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQV
VCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISI
SLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIL
KQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLE
KKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYL
NSLINPIIYTMSNEDFKQAFHKLIRFKCTS

NT seq 1173 nt +upstreamnt +downstreamnt
atggaggaaccgggtgctcagtgcgctccaccgccgcccgcgggctccgagacctgggtt
cctcaagccaacttatcctctgctccctcccaaaactgcagcgccaaggactacatttac
caggactccatctccctaccctggaaagtactgctggttatgctattggcgctcatcacc
ttggccaccacgctctccaatgcctttgtgattgccacagtgtaccggacccggaaactg
cacaccccggctaactacctgatcgcctctctggcggtcaccgacctgcttgtgtccatc
ctggtgatgcccatcagcaccatgtacactgtcaccggccgctggacactgggccaggtg
gtctgtgacttctggctgtcgtcggacatcacttgttgcactgcctccatcctgcacctc
tgtgtcatcgccctggaccgctactgggccatcacggacgccgtggagtactcagctaaa
aggactcccaagagggcggcggtcatgatcgcgctggtgtgggtcttctccatctctatc
tcgctgccgcccttcttctggcgtcaggctaaggccgaagaggaggtgtcggaatgcgtg
gtgaacaccgaccacatcctctacacggtctactccacggtgggtgctttctacttcccc
accctgctcctcatcgccctctatggccgcatctacgtagaagcccgctcccggattttg
aaacagacgcccaacaggaccggcaagcgcttgacccgagcccagctgataaccgactcc
cccgggtccacgtcctcggtcacctctattaactcgcgggttcccgacgtgcccagcgaa
tccggatctcctgtgtatgtgaaccaagtcaaagtgcgagtctccgacgccctgctggaa
aagaagaaactcatggccgctagggagcgcaaagccaccaagaccctagggatcattttg
ggagcctttattgtgtgttggctacccttcttcatcatctccctagtgatgcctatctgc
aaagatgcctgctggttccacctagccatctttgacttcttcacatggctgggctatctc
aactccctcatcaaccccataatctataccatgtccaatgaggactttaaacaagcattc
cataaactgatacgttttaagtgcacaagttga

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