KEGG   DRUG: Metformin hydrochloride
Entry
D00944                      Drug                                   

Name
Metformin hydrochloride (JP17/USP);
Glucophage (TN)
Product
  Generic
METFORMIN (Ingenus Pharmaceuticals), METFORMIN HYDROCHLORIDE (Mylan Pharmaceuticals), METFORMIN ER 500 MG (Granules India), METFORMIN (Granules Pharmaceuticals), METFORMIN HCL (A-S Medication Solutions), METFORMIN HCL (A-S Medication Solutions), METFORMIN HCL (A-S Medication Solutions), METFORMIN HCL (A-S Medication Solutions), METFORMIN HCL (Ascend Laboratories), METFORMIN HCL (Bryant Ranch Prepack), METFORMIN HCL (Bryant Ranch Prepack), METFORMIN HCL (Cambridge Therapeutics Technologies), METFORMIN HCL (Denton Pharma), METFORMIN HCL (Denton Pharma), METFORMIN HCL (Lake Erie Medical DBA Quality Care Products LLC), METFORMIN HCL (NuCare Pharmaceuticals), METFORMIN HCL (QPharma), METFORMIN HCL (RedPharm Drug), METFORMIN HCL (TIME CAP LABORATORIES), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (ACI Healthcare USA), METFORMIN HYDROCHLORIDE (Actavis Pharma), METFORMIN HYDROCHLORIDE (Actavis Pharma), METFORMIN HYDROCHLORIDE (Ajanta Pharma Limited), METFORMIN HYDROCHLORIDE (AlignScience Pharma), METFORMIN HYDROCHLORIDE (American Health Packaging), METFORMIN HYDROCHLORIDE (Amneal Pharmaceuticals LLC), METFORMIN HYDROCHLORIDE (Amneal Pharmaceuticals LLC), METFORMIN HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), METFORMIN HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Apotex Corp.), METFORMIN HYDROCHLORIDE (Apotheca), METFORMIN HYDROCHLORIDE (Ascend Laboratories), METFORMIN HYDROCHLORIDE (Ascend Laboratories), METFORMIN HYDROCHLORIDE (Aurobindo Pharma Limited), METFORMIN HYDROCHLORIDE (Aurobindo Pharma Limited), METFORMIN HYDROCHLORIDE (AvKARE), METFORMIN HYDROCHLORIDE (AvKARE), METFORMIN HYDROCHLORIDE (AvKARE), METFORMIN HYDROCHLORIDE (AvKARE), METFORMIN HYDROCHLORIDE (AvPAK), METFORMIN HYDROCHLORIDE (Bayshore Pharmaceuticals LLC), METFORMIN HYDROCHLORIDE (Breckenridge Pharmaceutical), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE EXTENDED RELEASE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Cadila Healthcare Limited), METFORMIN HYDROCHLORIDE (Cambridge Therapeutics Technologies), METFORMIN HYDROCHLORIDE (Cardinal Health), METFORMIN HYDROCHLORIDE (Cardinal Health), METFORMIN HYDROCHLORIDE (Cardinal Health), METFORMIN HYDROCHLORIDE (Cardinal Health), METFORMIN HYDROCHLORIDE (Carlsbad Technology), METFORMIN HYDROCHLORIDE (Clinical Solutions Wholesale), METFORMIN HYDROCHLORIDE (Contract Pharmacy Services-PA), METFORMIN HYDROCHLORIDE (DIRECT RX), METFORMIN HYDROCHLORIDE (Denton Pharma), METFORMIN HYDROCHLORIDE (Denton Pharma), METFORMIN HYDROCHLORIDE (Denton Pharma), METFORMIN HYDROCHLORIDE (Denton Pharma), METFORMIN HYDROCHLORIDE (Denton Pharma), METFORMIN HYDROCHLORIDE (Denton Pharma), METFORMIN HYDROCHLORIDE (Denton Pharma), METFORMIN HYDROCHLORIDE (Denton Pharma), METFORMIN HYDROCHLORIDE (Denton Pharma), METFORMIN HYDROCHLORIDE (Denton Pharma), METFORMIN HYDROCHLORIDE (Direct Rx), METFORMIN HYDROCHLORIDE (DirectRX), METFORMIN HYDROCHLORIDE EXTENDED RELEASE (Direct_Rx), METFORMIN HYDROCHLORIDE (Direct_Rx), METFORMIN HYDROCHLORIDE (Direct_Rx), METFORMIN HYDROCHLORIDE (Direct_Rx), METFORMIN HYDROCHLORIDE (Eon Labs), METFORMIN HYDROCHLORIDE (Epic Pharma), METFORMIN HYDROCHLORIDE (Epic Pharma), METFORMIN HYDROCHLORIDE (GLENMARK PHARMACEUTICALS), METFORMIN HYDROCHLORIDE (GRAXCELL PHARMACEUTICAL), METFORMIN HYDROCHLORIDE (Golden State Medical Supply), METFORMIN HYDROCHLORIDE (Golden State Medical Supply), METFORMIN HYDROCHLORIDE (Granules Pharmaceuticals), METFORMIN HYDROCHLORIDE (Heritage Pharmaceuticals), METFORMIN HYDROCHLORIDE (INDICUS PHARMA LLC), METFORMIN HYDROCHLORIDE (Ingenus Pharmaceuticals), METFORMIN HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), METFORMIN HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), METFORMIN HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), METFORMIN HYDROCHLORIDE (Laurus Labs Limited), METFORMIN HYDROCHLORIDE (Legacy Pharmaceutical Packaging), METFORMIN HYDROCHLORIDE (Legacy Pharmaceutical Packaging), METFORMIN HYDROCHLORIDE (Legacy Pharmaceutical Packaging), METFORMIN HYDROCHLORIDE (Legacy Pharmaceutical Packaging), METFORMIN HYDROCHLORIDE (Legacy Pharmaceutical Packaging), METFORMIN HYDROCHLORIDE (Lupin Pharmaceuticals), METFORMIN HYDROCHLORIDE (Lupin Pharmaceuticals), METFORMIN HYDROCHLORIDE (MARKSANS PHARMA LIMITED), METFORMIN HYDROCHLORIDE (MARKSANS PHARMA LIMITED), METFORMIN HYDROCHLORIDE ORAL SOLUTION (MICRO LABS LIMITED), METFORMIN HYDROCHLORIDE (Macleods Pharmaceuticals Limited), METFORMIN HYDROCHLORIDE (Major Pharmaceuticals), METFORMIN HYDROCHLORIDE (Major Pharmaceuticals), METFORMIN HYDROCHLORIDE (McKesson Corporation dba SKY Packaging), METFORMIN HYDROCHLORIDE (McKesson Corporation dba SKY Packaging), METFORMIN HYDROCHLORIDE (Medsource Pharmaceuticals), METFORMIN HYDROCHLORIDE (Metcure Pharmaceuticals), METFORMIN HYDROCHLORIDE (Mylan Institutional), METFORMIN HYDROCHLORIDE (Mylan Pharmaceuticals), METFORMIN HYDROCHLORIDE (NCS HealthCare of KY), METFORMIN HYDROCHLORIDE (NCS HealthCare of KY), METFORMIN HYDROCHLORIDE (NorthStar RxLLC), METFORMIN HYDROCHLORIDE (Nostrum Laboratories), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE EXTENDED RELEASE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmaceuticals), METFORMIN HYDROCHLORIDE (NuCare Pharmarmaceuticals), METFORMIN HYDROCHLORIDE (Oceanside Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE EXTENDED RELEASE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE EXTENDED RELEASE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE EXTENDED RELEASE (Preferred Pharmaceuticals), METFORMIN HYDROCHLORIDE EXTENDED RELEASE (Preferred Pharmaceuticals), METFORMIN HYDROCHLORIDE (Preferred Pharmaceuticals), METFORMIN HYDROCHLORIDE (Preferred Pharmaceuticals), METFORMIN HYDROCHLORIDE (Preferred Pharmaceuticals), METFORMIN HYDROCHLORIDE (Preferred Pharmaceuticals), METFORMIN HYDROCHLORIDE (Preferred Pharmaceuticals), METFORMIN HYDROCHLORIDE (Proficient Rx LP), METFORMIN HYDROCHLORIDE (Proficient Rx LP), METFORMIN HYDROCHLORIDE (Proficient Rx LP), METFORMIN HYDROCHLORIDE (Proficient Rx LP), METFORMIN HYDROCHLORIDE (Proficient Rx LP), METFORMIN HYDROCHLORIDE (Proficient Rx LP), METFORMIN HYDROCHLORIDE (Proficient Rx LP), METFORMIN HYDROCHLORIDE (Proficient Rx LP), METFORMIN HYDROCHLORIDE (PuraCap Laboratories LLC dba Blu Pharmaceuticals), METFORMIN HYDROCHLORIDE (QPharma), METFORMIN HYDROCHLORIDE (QPharma), METFORMIN HYDROCHLORIDE (Quality Care Products), METFORMIN HYDROCHLORIDE (Quality Care Products), METFORMIN HYDROCHLORIDE (Quality Care Products), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE EXTENDED RELEASE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (RedPharm Drug), METFORMIN HYDROCHLORIDE (RedPharm Drug), METFORMIN HYDROCHLORIDE (RedPharm Drug), METFORMIN HYDROCHLORIDE (RedPharm Drug), METFORMIN HYDROCHLORIDE (RedPharm Drug), METFORMIN HYDROCHLORIDE (RedPharm Drug), METFORMIN HYDROCHLORIDE (RedPharm Drug), METFORMIN HYDROCHLORIDE (RedPharm Drug), METFORMIN HYDROCHLORIDE (RedPharm Drug), METFORMIN HYDROCHLORIDE (ScieGen Pharmaceuticals), METFORMIN HYDROCHLORIDE (Slate Run Pharmaceuticals), METFORMIN HYDROCHLORIDE (Solco Healthcare U.S.), METFORMIN HYDROCHLORIDE (St Marys Medical Park Pharmacy), METFORMIN HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), METFORMIN HYDROCHLORIDE EXTENDED RELEASE (St. Marys Medical Park Pharmacy), METFORMIN HYDROCHLORIDE (Sun Pharmaceutical Industries), METFORMIN HYDROCHLORIDE (Sun Pharmaceutical Industries), METFORMIN HYDROCHLORIDE (Sun Pharmaceutical Industries), METFORMIN HYDROCHLORIDE (Sunshine Lake Pharma), METFORMIN HYDROCHLORIDE (TAGI Pharma), METFORMIN HYDROCHLORIDE (TAGI Pharma), METFORMIN HYDROCHLORIDE EXTENDED RELEASE (TIME CAP LABORATORIES), METFORMIN HYDROCHLORIDE (Teva Pharmaceuticals USA), METFORMIN HYDROCHLORIDE (Unit Dose Services), METFORMIN HYDROCHLORIDE (Unit Dose Services), METFORMIN HYDROCHLORIDE (Viona Pharmaceuticals), METFORMIN HYDROCHLORIDE (Westminster Pharmaceuticals), METFORMIN HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), METFORMIN HYDROCHLORIDE (AiPing Pharmaceutical), METFORMIN HYDROCHLORIDE (Qingdao BAHEAL Pharmaceutical), METFORMIN HYDROCHLORIDE (Granules India), METFORMIN HYDROCHLORIDE (EPIC PHARMA)
Formula
C4H11N5. HCl
Exact mass
165.0781
Mol weight
165.6246
Structure
Simcomp
Class
Antidiabetic agent
 DG01685  Insulin sensitizer
  DG01684  Biguanide antidiabetic
 DG02044  Hypoglycemics
  DG01684  Biguanide antidiabetic
Remark
Therapeutic category: 3962
ATC code: A10BA02
Chemical structure group: DG00113
Product (DG00113): D00944<JP/US>
Product (mixture): D09744<JP/US> D10253<JP/US> D10261<US> D10263<US> D10264<US> D10265<US> D10266<US> D10586<US> D10587<US> D10743<JP> D10752<US> D11067<US> D11109<JP> D11711<US>
Efficacy
Antidiabetic, Hypoglycemic, AMP kinase activator
  Disease
Type 2 diabetes mellitus [DS:H00409]
Comment
Biguanide
Target
AMPK (PRKAA) [HSA:5562 5563] [KO:K07198]
  Pathway
hsa04152  AMPK signaling pathway
hsa04910  Insulin signaling pathway
hsa04920  Adipocytokine signaling pathway
Interaction
Structure map
map07051  Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BA Biguanides
     A10BA02 Metformin
      D00944  Metformin hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Biguanides
    Metformin
     D00944  Metformin hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3962  Biguanides
     D00944  Metformin hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine kinases
   CAMK group
    AMPK (PRKAA)
     D00944  Metformin hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00944  Metformin hydrochloride
  D00944  Metformin hydrochloride tablets
Other DBs
CAS: 1115-70-4
PubChem: 7848007
ChEBI: 6802
ChEMBL: CHEMBL1703
DrugBank: DB00331
LigandBox: D00944
NIKKAJI: J237.891D
LinkDB
KCF data

ATOM        10
            1   C2c C    25.2991  -19.3605
            2   N1b N    24.0935  -18.6673
            3   N1c N    26.5163  -18.6673
            4   N2a N    25.2991  -20.7640
            5   C2c C    22.8764  -19.3605
            6   C1a C    27.7278  -19.3605
            7   C1a C    26.5163  -17.2579
            8   N1a N    21.6649  -18.6673
            9   N2a N    22.8764  -20.7640
            10  X   Cl   31.1135  -18.2132
BOND        8
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     5   8 1
            8     5   9 2

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