| Entry |
|
|---|
| Name |
Doxazosin (INN);
Cardura XL (TN) |
|---|
| Formula |
C23H25N5O5
|
|---|
| Exact mass |
451.1856
|
|---|
| Mol weight |
451.47
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG01739 Peripherally-acting antiadrenergic
DG03231 Antihypertensive
|
|---|
| Remark |
| Product (DG00256): | D00608<JP/US> |
|
|---|
| Efficacy |
Antihypertensive, alpha1-Adrenergic receptor antagonist |
|---|
| Comment |
Prazosin derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07215 | alpha-Adrenergic receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C02 ANTIHYPERTENSIVES
C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
C02CA Alpha-adrenoreceptor antagonists
C02CA04 Doxazosin
D07874 Doxazosin (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG00256 Doxazosin
D07874 Doxazosin
DG01739 Peripherally-acting antiadrenergic
DG00256 Doxazosin
D07874 Doxazosin
DG03231 Antihypertensive
DG00256 Doxazosin
D07874 Doxazosin
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D07874 Doxazosin (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG00256 Doxazosin
DG01739 Peripherally-acting antiadrenergic
DG00256 Doxazosin
DG03231 Antihypertensive
DG00256 Doxazosin
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 33
1 C8y C 28.3500 -18.2700
2 C8y C 28.3500 -19.6700
3 N5x N 27.1600 -17.5700
4 C8x C 29.6100 -17.5700
5 C8x C 29.5400 -20.3700
6 C8y C 27.1600 -20.3700
7 C8y C 25.9700 -18.2700
8 C8y C 30.8000 -18.2700
9 C8y C 30.8000 -19.6700
10 N5x N 25.9700 -19.6700
11 N1a N 27.1600 -21.7700
12 N1y N 24.7100 -17.5700
13 O2a O 31.9900 -17.5700
14 O2a O 31.9900 -20.3700
15 C1x C 23.5200 -18.2700
16 C1x C 24.7100 -16.1700
17 C1a C 33.2500 -18.2700
18 C1a C 33.1800 -19.6700
19 C1x C 22.3300 -17.5700
20 C1x C 23.5200 -15.4700
21 N1y N 22.3300 -16.1700
22 C5a C 21.1400 -15.4700
23 C1y C 19.8800 -16.1700
24 O5a O 21.1400 -14.0700
25 O2x O 18.6900 -15.4700
26 C1x C 19.8800 -17.5700
27 C8y C 17.4300 -16.1700
28 O2x O 18.6900 -18.2700
29 C8y C 17.4300 -17.5700
30 C8x C 16.2400 -15.4700
31 C8x C 16.2400 -18.2700
32 C8x C 15.0500 -16.1700
33 C8x C 15.0500 -17.5700
BOND 37
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 2 6 2
6 3 7 1
7 4 8 2
8 5 9 2
9 6 10 1
10 6 11 1
11 7 12 1
12 8 13 1
13 9 14 1
14 12 15 1
15 12 16 1
16 13 17 1
17 14 18 1
18 15 19 1
19 16 20 1
20 19 21 1
21 21 22 1
22 22 23 1
23 22 24 2
24 23 25 1
25 23 26 1
26 25 27 1
27 26 28 1
28 27 29 1
29 27 30 2
30 29 31 2
31 30 32 1
32 31 33 1
33 7 10 2
34 8 9 1
35 20 21 1
36 28 29 1
37 32 33 2
|
|---|
