KEGG   DRUG: Ketamine
Entry
D08098                      Drug                                   
Name
Ketamine (INN);
Tekam (TN)
Formula
C13H16ClNO
Exact mass
237.0920
Mol weight
237.72
Structure
Simcomp
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG02027  General anesthetics
 DG01498  NMDA receptor antagonist
Remark
Same as: C07525
ATC code: N01AX03
Chemical structure group: DG00796
Product (DG00796): D00711<JP/US>
Efficacy
Anesthetic (intravenous), NMDA receptor antagonist
Comment
Phencyclidine derivative
Target
GRIN (NMDAR) [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
Interaction
Structure map
map07235  N-Methyl-D-aspartic acid (NMDA) receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01A ANESTHETICS, GENERAL
    N01AX Other general anesthetics
     N01AX03 Ketamine
      D08098  Ketamine (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG02030  Anesthetics
   DG02027  General anesthetics
    DG00796  Ketamine
     D08098  Ketamine
  DG01498  NMDA receptor antagonist
   DG00796  Ketamine
    D08098  Ketamine
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Glutamate (ionotropic), NMDA
    GRIN (NMDAR)
     D08098  Ketamine (INN)
Narcotics and psychotropics in Japan [br08308.html]
 Narcotics by Cabinet Order Article 1 (157 substances)
  D08098
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG02030  Anesthetics
   DG02027  General anesthetics
    DG00796  Ketamine
  DG01498  NMDA receptor antagonist
   DG00796  Ketamine
Other DBs
CAS: 6740-88-1
PubChem: 96024788
ChEBI: 6121
LigandBox: D08098
NIKKAJI: J244.885H
LinkDB
KCF data

ATOM        16
            1   C1z C    24.9200  -17.7800
            2   C8y C    23.7300  -18.4800
            3   C5x C    26.3200  -17.7800
            4   C1x C    24.2200  -16.5900
            5   N1b N    25.6200  -18.9700
            6   C8y C    22.4700  -17.7800
            7   C8x C    23.7300  -19.8800
            8   C1x C    27.0200  -16.5200
            9   O5x O    27.0200  -18.9700
            10  C1x C    24.9200  -15.3300
            11  C1a C    24.9200  -20.2300
            12  C8x C    21.2800  -18.4800
            13  X   Cl   22.4700  -16.3800
            14  C8x C    22.4700  -20.5800
            15  C1x C    26.3200  -15.3300
            16  C8x C    21.2800  -19.8800
BOND        17
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 2
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    6  13 1
            13    7  14 2
            14    8  15 1
            15   12  16 2
            16   10  15 1
            17   14  16 1

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