KEGG   DRUG: Plecanatide
Entry
D09948                      Drug                                   
Name
Plecanatide (USAN/INN);
Trulance (TN)
Product
TRULANCE (Salix Pharmaceuticals)
Formula
C65H104N18O26S4
Exact mass
1680.6252
Mol weight
1681.90
Structure
Sequence
Asn Asp Glu Cys Glu Leu Cys Val Asn Val Ala Cys Thr Gly Cys Leu
(Disulfide bridge: 4-12, 7-15)
  Type
Peptide
Remark
ATC code: A06AX07
Product: D09948<US>
Efficacy
Peristaltic accelerator, Enterotoxin receptor agonist
  Disease
Irritable bowel syndrome [DS:H01615]
Comment
synthetic analog of Uroguanylin [CPD:C16006]
Chronic constipation, irritable bowel syndrome with constipation
Target
GUCY2C [HSA:2984] [KO:K12320]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A06 DRUGS FOR CONSTIPATION
   A06A DRUGS FOR CONSTIPATION
    A06AX Other drugs for constipation
     A06AX07 Plecanatide
      D09948  Plecanatide (USAN/INN) <US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Anti-constipation Agents
   Plecanatide
    D09948  Plecanatide (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Lyases (EC4)
   Phosphorus-oxygen lyases
    GUCY2C
     D09948  Plecanatide (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09948
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09948
Other DBs
CAS: 467426-54-6
PubChem: 124490630
LinkDB

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