Homo sapiens (human): 2984
Help
Entry
2984 CDS
T01001
Symbol
GUCY2C, DIAR6, GC-C, GCC, GUC2C, HSER, MECIL, MUCIL, STAR
Name
(RefSeq) guanylate cyclase 2C
KO
K12320
heat-stable enterotoxin receptor [EC:
4.6.1.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
Disease
H01174
Congenital diarrhea
H01615
Irritable bowel syndrome
Drug target
Dolcanatide:
D11233
Linaclotide (
DG00079
):
D06612
D09355
<JP/US>
Plecanatide:
D09948
<US>
Recanaclotide:
D10976
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
2984 (GUCY2C)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
2984 (GUCY2C)
Enzymes [BR:
hsa01000
]
4. Lyases
4.6 Phosphorus-oxygen lyases
4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)
4.6.1.2 guanylate cyclase
2984 (GUCY2C)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: Other
RGC family [OT]
2984 (GUCY2C)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Guanylate_cyc
PK_Tyr_Ser-Thr
Pkinase
ANF_receptor
LapA_dom
DUF6293_C
Motif
Other DBs
NCBI-GeneID:
2984
NCBI-ProteinID:
NP_004954
OMIM:
601330
HGNC:
4688
Ensembl:
ENSG00000070019
Pharos:
P25092
(Tclin)
UniProt:
P25092
Structure
PDB
PDBj
LinkDB
All DBs
Position
12:complement(14612632..14696599)
Genome browser
AA seq
1073 aa
AA seq
DB search
MKTLLLDLALWSLLFQPGWLSFSSQVSQNCHNGSYEISVLMMGNSAFAEPLKNLEDAVNE
GLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAQRMGCVLI
GPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDL
PFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHN
RKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTLS
PGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTF
EGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKL
PNDITGRGPQILMIAVFTLTGAVVLLLLVALLMLRKYRKDYELRQKKWSHIPPENIFPLE
TNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQID
YYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKG
MSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQANISQK
GDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEV
YLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVE
ERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYS
TPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEI
LSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPL
RIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQ
RLQAEFSDMIANSLQKRQAAGIRSQKPRRVASYKKGTLEYLQLNTTDKESTYF
NT seq
3222 nt
NT seq
+upstream
nt +downstream
nt
atgaagacgttgctgttggacttggctttgtggtcactgctcttccagcccgggtggctg
tcctttagttcccaggtgagtcagaactgccacaatggcagctatgaaatcagcgtcctg
atgatgggcaactcagcctttgcagagcccctgaaaaacttggaagatgcggtgaatgag
gggctggaaatagtgagaggacgtctgcaaaatgctggcctaaatgtgactgtgaacgct
actttcatgtattcggatggtctgattcataactcaggcgactgccggagtagcacctgt
gaaggcctcgacctactcaggaaaatttcaaatgcacaacggatgggctgtgtcctcata
gggccctcatgtacatactccaccttccagatgtaccttgacacagaattgagctacccc
atgatctcagctggaagttttggattgtcatgtgactataaagaaaccttaaccaggctg
atgtctccagctagaaagttgatgtacttcttggttaacttttggaaaaccaacgatctg
cccttcaaaacttattcctggagcacttcgtatgtttacaagaatggtacagaaactgag
gactgtttctggtaccttaatgctctggaggctagcgtttcctatttctcccacgaactc
ggctttaaggtggtgttaagacaagataaggagtttcaggatatcttaatggaccacaac
aggaaaagcaatgtgattattatgtgtggtggtccagagttcctctacaagctgaagggt
gaccgagcagtggctgaagacattgtcattattctagtggatcttttcaatgaccagtac
tttgaggacaatgtcacagcccctgactatatgaaaaatgtccttgttctgacgctgtct
cctgggaattcccttctaaatagctctttctccaggaatctatcaccaacaaaacgagac
tttgctcttgcctatttgaatggaatcctgctctttggacatatgctgaagatatttctt
gaaaatggagaaaatattaccacccccaaatttgctcatgctttcaggaatctcactttt
gaagggtatgacggtccagtgaccttggatgactggggggatgttgacagtaccatggtg
cttctgtatacctctgtggacaccaagaaatacaaggttcttttgacctatgatacccac
gtaaataagacctatcctgtggatatgagccccacattcacttggaagaactctaaactt
cctaatgatattacaggccggggccctcagatcctgatgattgcagtcttcaccctcact
ggagctgtggtgctgctcctgctcgtcgctctcctgatgctcagaaaatatagaaaagat
tatgaacttcgtcagaaaaaatggtcccacattcctcctgaaaatatctttcctctggag
accaatgagaccaatcatgttagcctcaagatcgatgatgacaaaagacgagatacaatc
cagagactacgacagtgcaaatacgacaaaaagcgagtgattctcaaagatctcaagcac
aatgatggtaatttcactgaaaaacagaagatagaattgaacaagttgcttcagattgac
tattacaacctgaccaagttctacggcacagtgaaacttgataccatgatcttcggggtg
atagaatactgtgagagaggatccctccgggaagttttaaatgacacaatttcctaccct
gatggcacattcatggattgggagtttaagatctctgtcttgtatgacattgctaaggga
atgtcatatctgcactccagtaagacagaagtccatggtcgtctgaaatctaccaactgc
gtagtggacagtagaatggtggtgaagatcactgattttggctgcaattccattttacct
ccaaaaaaggacctgtggacagctccagagcacctccgccaagccaacatctctcagaaa
ggagatgtgtacagctatgggatcatcgcacaggagatcatcctgcggaaagaaaccttc
tacactttgagctgtcgggaccggaatgagaagattttcagagtggaaaattccaatgga
atgaaacccttccgcccagatttattcttggaaacagcagaggaaaaagagctagaagtg
tacctacttgtaaaaaactgttgggaggaagatccagaaaagagaccagatttcaaaaaa
attgagactacacttgccaagatatttggactttttcatgaccaaaaaaatgaaagctat
atggataccttgatccgacgtctacagctatattctcgaaacctggaacatctggtagag
gaaaggacacagctgtacaaggcagagagggacagggctgacagacttaactttatgttg
cttccaaggctagtggtaaagtctctgaaggagaaaggctttgtggagccggaactatat
gaggaagttacaatctacttcagtgacattgtaggtttcactactatctgcaaatacagc
acccccatggaagtggtggacatgcttaatgacatctataagagttttgaccacattgtt
gatcatcatgatgtctacaaggtggaaaccatcggtgatgcgtacatggtggctagtggt
ttgcctaagagaaatggcaatcggcatgcaatagacattgccaagatggccttggaaatc
ctcagcttcatggggacctttgagctggagcatcttcctggcctcccaatatggattcgc
attggagttcactctggtccctgtgctgctggagttgtgggaatcaagatgcctcgttat
tgtctatttggagatacggtcaacacagcctctaggatggaatccactggcctccctttg
agaattcacgtgagtggctccaccatagccatcctgaagagaactgagtgccagttcctt
tatgaagtgagaggagaaacatacttaaagggaagaggaaatgagactacctactggctg
actgggatgaaggaccagaaattcaacctgccaacccctcctactgtggagaatcaacag
cgtttgcaagcagaattttcagacatgattgccaactctttacagaaaagacaggcagca
gggataagaagccaaaaacccagacgggtagccagctataaaaaaggcactctggaatac
ttgcagctgaataccacagacaaggagagcacctatttttaa
DBGET
integrated database retrieval system
