KEGG ORTHOLOGY: K12320

ORTHOLOGY: K12320

Entry

K12320                      KO

Symbol

GUCY2C

Name

heat-stable enterotoxin receptor [EC:4.6.1.2]

Pathway

map00230

Purine metabolism

map01100

Metabolic pathways

Reaction

R00434

GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)

Disease

H01174

Congenital diarrhea

H01615

Irritable bowel syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K12320  GUCY2C; heat-stable enterotoxin receptor
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K12320  GUCY2C; heat-stable enterotoxin receptor
Enzymes [BR:ko01000]
4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.2  guanylate cyclase
     K12320  GUCY2C; heat-stable enterotoxin receptor
Protein kinases [BR:ko01001]
Serine/threonine kinases: Other
  RGC family [OT]
   K12320  GUCY2C; heat-stable enterotoxin receptor

Other DBs

GO:

0004383

Genes

HSA:	2984(GUCY2C)

PTR:	473375(GUCY2C)

PPS:	100975209(GUCY2C)

GGO:	101138030(GUCY2C)

PON:	100460918(GUCY2C)

PPYG:

129010392(GUCY2C)

NLE:	100594944(GUCY2C)

HMH:	116472715(GUCY2C)

SSYN:

129483309(GUCY2C)

MCC:	699191(GUCY2C)

MCF:	102130850(GUCY2C)

MTHB:

126931301

MNI:	105481896(GUCY2C)

CSAB:

103218671(GUCY2C)

CATY:

105585122(GUCY2C)

PANU:

101013490(GUCY2C)

TGE:	112635552(GUCY2C)

MLEU:

105547298(GUCY2C)

RRO:	104666399(GUCY2C)

RBB:	108530463(GUCY2C)

TFN:	117090471(GUCY2C)

PTEH:

111552055(GUCY2C)

CANG:

105520447(GUCY2C)

CJC:	100406002(GUCY2C)

SBQ:	101038981(GUCY2C)

CIMI:

108304238(GUCY2C)

ANAN:

105713837(GUCY2C)

CSYR:

103274431(GUCY2C)

MMUR:

105865281(GUCY2C)

LCAT:

123640695(GUCY2C)

PCOQ:

105816676(GUCY2C)

OGA:	100951382(GUCY2C)

MMU:	14917(Gucy2c)

MCAL:

110296529(Gucy2c)

MPAH:

110316487(Gucy2c)

RNO:	25711(Gucy2c)

MCOC:

116098405(Gucy2c)

ANU:	117715258(Gucy2c)

MUN:	110552758(Gucy2c)

CGE:	100757969(Gucy2c)

MAUA:

101825481(Gucy2c)

PROB:

127212941(Gucy2c)

PLEU:

114695054(Gucy2c)

MORG:

121437718(Gucy2c)

MFOT:

126497258

AAMP:

119806946(Gucy2c)

NGI:	103752330(Gucy2c)

HGL:	101720874(Gucy2c)

CPOC:

100135536(Gucy2c)

CCAN:

109696930(Gucy2c)

DORD:

105992222(Gucy2c)

DSP:	122101239(Gucy2c)

PLOP:

125342737(Gucy2c)

NCAR:

124983255

MMMA:

107152688(Gucy2c)

OCU:

100008740

OPI:	101523873(GUCY2C)

TUP:	102495739(GUCY2C)

GVR:	103595655(GUCY2C)

CFA:	486671(GUCY2C)

CLUD:

112665564(GUCY2C)

VVP:	112917486(GUCY2C)

VLG:	121480133(GUCY2C)

NPO:	129517154(GUCY2C)

AML:	100468576(GUCY2C)

UMR:	103677772(GUCY2C)

UAH:	113257858(GUCY2C)

UAR:	123781773(GUCY2C)

ELK:

111142267

LLV:

125107728

MPUF:

101680691(GUCY2C)

MNP:	132020617(GUCY2C)

MLK:	131839009(GUCY2C)

NVS:	122891786(GUCY2C)

ORO:	101382463(GUCY2C)

EJU:	114221649(GUCY2C)

ZCA:	113921303(GUCY2C)

MLX:	118025633(GUCY2C)

NSU:	110580798(GUCY2C)

LWW:	102729228(GUCY2C)

FCA:	101095109(GUCY2C)

PYU:	121038884(GUCY2C)

PCOO:

112867364(GUCY2C)

PBG:	122473892(GUCY2C)

PVIV:

125169966(GUCY2C)

LRUF:

124501538

PTG:	102963095(GUCY2C)

PPAD:

109268647(GUCY2C)

PUC:

125918864

AJU:

106965660

HHV:	120236860(GUCY2C)

BTA:	282244(GUCY2C)

BOM:	102284444(GUCY2C)

BIU:	109559629(GUCY2C)

BBUB:

102402674(GUCY2C)

BBIS:

105002189(GUCY2C)

CHX:	108636048(GUCY2C)

OAS:	101108212(GUCY2C)

BTAX:

128048467(GUCY2C)

ODA:	120858885(GUCY2C)

CCAD:

122423819(GUCY2C)

MBEZ:

129535651(GUCY2C)

SSC:	397193(GUCY2C)

CFR:	102516411(GUCY2C)

CBAI:

105062249(GUCY2C)

CDK:	105096521(GUCY2C)

VPC:	102537776(GUCY2C)

BACU:

103006662(GUCY2C)

BMUS:

118901508(GUCY2C)

LVE:	103081407(GUCY2C)

OOR:	101284028(GUCY2C)

DLE:	111176790(GUCY2C)

PCAD:

102978761(GUCY2C)

PSIU:

116761233(GUCY2C)

NASI:

112391853(GUCY2C)

ECB:	100063810(GUCY2C)

EPZ:	103559389(GUCY2C)

EAI:	106826729(GUCY2C)

MYB:	102247939(GUCY2C)

MYD:	102772626(GUCY2C)

MMYO:

118649494(GUCY2C)

MLF:	102435698(GUCY2C)

MDT:	132227328(GUCY2C)

PKL:	118728666(GUCY2C)

EFUS:

103285109(GUCY2C)

MNA:	107525360(GUCY2C)

DRO:	112318447(GUCY2C)

SHON:

118978455(GUCY2C)

AJM:	119042841(GUCY2C)

PDIC:

114513616(GUCY2C)

PHAS:

123812733(GUCY2C)

MMF:	118624727(GUCY2C)

PPAM:

129084723(GUCY2C)

HAI:	109383130(GUCY2C)

RFQ:	117027966(GUCY2C)

PALE:

102883474(GUCY2C)

PGIG:

120613746(GUCY2C)

PVP:	105302778(GUCY2C)

RAY:	107508610(GUCY2C)

MJV:	108397788(GUCY2C)

TOD:	119247682(GUCY2C)

SARA:

101542508(GUCY2C)

SETR:

126022034(GUCY2C)

LAV:	100675825(GUCY2C)

TMU:

101340932

ETF:	101652559(GUCY2C)

DNM:	101421088(GUCY2C)

MDO:	100016988(GUCY2C)

GAS:	123249097(GUCY2C)

SHR:	100925538(GUCY2C)

AFZ:

127564357

PCW:	110213823(GUCY2C)

TVP:	118850728(GUCY2C)

OAA:	100091310(GUCY2C)

GGA:	417968(GUCY2C)

PCOC:

116233426(GUCY2C)

MGP:	100550786(GUCY2C)

CJO:	107313537(GUCY2C)

TPAI:

128073876(GUCY2C)

LMUT:

125693289(GUCY2C)

NMEL:

110392293(GUCY2C)

APLA:

101802157(GUCY2C)

ACYG:

106046052(GUCY2C)

CATA:

118246842(GUCY2C)

AFUL:

116499811(GUCY2C)

TGU:	100228246(GUCY2C)

LSR:	110483071(GUCY2C)

SCAN:

103813321(GUCY2C)

PMOA:

120498350(GUCY2C)

OTC:	121342383(GUCY2C)

PRUF:

121361116(GUCY2C)

GFR:	102042400(GUCY2C)

FAB:	101816039(GUCY2C)

OMA:	130248566(GUCY2C)

PHI:	102111535(GUCY2C)

PMAJ:

107204266(GUCY2C)

CCAE:

111934182(GUCY2C)

CCW:	104696375(GUCY2C)

CBRC:

103618132(GUCY2C)

ETL:	114064062(GUCY2C)

ZAB:	102063950(GUCY2C)

ZLE:	135457366(GUCY2C)

ACHL:

103811892(GUCY2C)

SVG:	106856913(GUCY2C)

MMEA:

130588573(GUCY2C)

HRT:	120751674(GUCY2C)

SATI:

136361728(GUCY2C)

FPG:	101913205(GUCY2C)

FCH:	102053014(GUCY2C)

CCRI:

104162048(GUCY2C)

NNT:	104412743(GUCY2C)

SHAB:

115605273(GUCY2C)

ACUN:

113491559(GUCY2C)

TALA:

104361832(GUCY2C)

ACHC:

115336322(GUCY2C)

HALD:

104313113(GUCY2C)

HLE:	104830732(GUCY2C)

AGEN:

126034559

GCL:

127020940

CSTI:

104558028(GUCY2C)

LDI:	104342506(GUCY2C)

MNB:	103772916(GUCY2C)

DPUB:

104301975(GUCY2C)

AVIT:

104275127(GUCY2C)

BRHI:

104498496(GUCY2C)

EGZ:	104134274(GUCY2C)

NNI:	104021662(GUCY2C)

PCRI:

104036062(GUCY2C)

PCAO:

104052962(GUCY2C)

PADL:

103915916(GUCY2C)

AFOR:

103907898(GUCY2C)

FGA:	104069131(GUCY2C)

GSTE:

104254180(GUCY2C)

CLV:	102098904(GUCY2C)

MUI:	104545165(GUCY2C)

PGUU:

104457980(GUCY2C)

PLET:

104627138(GUCY2C)

EHS:	104502570(GUCY2C)

CMAC:

104473141(GUCY2C)

CUCA:

104055472(GUCY2C)

TEO:	104373395(GUCY2C)

BREG:

104637525(GUCY2C)

OHA:	104329897(GUCY2C)

ACAR:

104527724(GUCY2C)

CPEA:

104394254(GUCY2C)

CVF:	104295468(GUCY2C)

RTD:	128913553(GUCY2C)

AAM:	106488668(GUCY2C)

AROW:

112967708(GUCY2C)

NPD:	112948190(GUCY2C)

TGT:	104575927(GUCY2C)

DNE:	112984535(GUCY2C)

SCAM:

104137926(GUCY2C)

ASN:	102374400(GUCY2C)

AMJ:	102558504(GUCY2C)

CPOO:

109316840(GUCY2C)

GGN:	109295825(GUCY2C)

PSS:	102444148(GUCY2C)

CMY:	102947911(GUCY2C)

CCAY:

125629961(GUCY2C)

DCC:	119861906(GUCY2C)

CPIC:

101940459 101941251(GUCY2C)

TST:	117873400(GUCY2C)

CABI:

116838131(GUCY2C) 116838132

MRV:	120373686 120374311

ACS:	100563369(gucy2c)

ASAO:

132775795(GUCY2C)

PVT:	110076095(GUCY2C)

SUND:

121931160(GUCY2C)

PBI:	103067773(GUCY2C)

PMUR:

107302973(GUCY2C)

CTIG:

120304719(GUCY2C)

TSR:

106539270

PGUT:

117655724(GUCY2C)

APRI:

131202558(GUCY2C)

PTEX:

113434367(GUCY2C)

NSS:	113432512(GUCY2C)

VKO:	123036240(GUCY2C)

PMUA:

114605114(GUCY2C)

PRAF:

128422603(GUCY2C)

ZVI:	118090801(GUCY2C)

HCG:	128327378(GUCY2C)

GJA:	107118370(GUCY2C)

STOW:

125434985(GUCY2C)

EMC:	129336123(GUCY2C)

XLA:	108715011(gucy2c.S) 378662(gucy2c.L)

XTR:	100486678(gucy2c)

BBUF:

120979823(GUCY2C)

BGAR:

122944173(GUCY2C)

MUO:	115475763(GUCY2C)

GSH:	117354858(GUCY2C)

DRE:	568219(gucy2cb) 572052(gucy2ca)

SRX:	107734164 107734784 107745524

SANH:

107663179 107672912

SGH:	107563725 107584206

CCAR:

109057374 109099913

CAUA:

113067759 113067886 113111718

CGIB:

127952511 127969282

PTET:

122329760(gucy2ca) 122355701(gucy2cb)

LROH:

127162859(gucy2ca) 127174066(gucy2cb)

OMC:	131536353(gucy2ca) 131551060(gucy2cb)

PPRM:

120488752(gucy2cb) 120490174(gucy2ca)

RKG:	130088609(gucy2cb)

MAMB:

125255424(gucy2cb) 125262712(gucy2ca)

CIDE:

127509868 127523429

CERY:

137007840(gucy2cb) 137017134(gucy2ca)

MASI:

127427236 127449819

TROS:

130556681(gucy2ca) 130569029(gucy2cb)

TDW:	130425865(gucy2ca) 130438894(gucy2cb)

MANU:

129420679(gucy2cb) 129436817(gucy2ca)

IPU:	108272812(gucy2ca) 108273417(gucy2cb)

IFU:	128615990(gucy2ca) 128617158(gucy2cb)

PHYP:

113527433(gucy2c) 113534683

SMEO:

124382101(gucy2ca) 124388700(gucy2cb)

TFD:	113637164(gucy2cb) 113652903(gucy2ca)

TVC:	132838954(gucy2cb) 132842653(gucy2ca)

TRN:	134309228(gucy2ca) 134321393(gucy2cb)

AMEX:

103035855(gucy2ca) 103043322(gucy2cb)

CMAO:

118803672

EEE:	113574817 113584860

CHAR:

105888742(gucy2cb)

TRU:	101069264 101074666 115248197

TFS:	130514489(gucy2ca) 130538440(gucy2cb)

TNG:	GSTEN00004712G001 GSTEN00006827G001 GSTEN00024235G001

LCO:	104918929 104932052(gucy2c)

TBEN:

117492167(gucy2c)

CGOB:

115012820 115024584

PGEO:

117451428(gucy2c) 117464627(si:ch73-139e5.4)

GACU:

117533446(si:ch73-139e5.4) 117534721(gucy2c)

EMAC:

134870549(gucy2cb) 134878663(gucy2ca)

ELY:	117246769(si:ch73-139e5.4) 117268026(gucy2c)

EFO:	125879239(gucy2ca) 125880429(gucy2cb)

PLEP:

121957007(gucy2ca) 121959101

SLUC:

116048739(si:ch73-139e5.4) 116065356(gucy2c)

ECRA:

117937134(si:ch73-139e5.4) 117957487(gucy2c)

ESP:	116671189 116702456

PFLV:

114548595 114569820

GAT:	120819861(gucy2cb) 120828300(gucy2ca)

PPUG:

119212556(si:ch73-139e5.4) 119220890(gucy2c)

AFB:	129091435(gucy2cb) 129098724(gucy2ca)

CLUM:

117734866(gucy2c) 117748500(si:ch73-139e5.4)

PSWI:

130189117(gucy2ca) 130203991(gucy2cb)

MSAM:

119884739(gucy2c) 119915580(si:ch73-139e5.4)

SCHU:

122867517(gucy2cb) 122869135(gucy2ca)

CUD:	121503561(gucy2ca) 121528353(gucy2cb)

ALAT:

119010266(si:ch73-139e5.4) 119013523(gucy2c)

ASTR:

137588843(gucy2cb) 137609989(gucy2ca)

MZE:	101465198 101477375

ONL:	100697917 100699375

OAU:	116327271(gucy2cb) 116327864(gucy2ca)

OLA:	100125818(olgc9) 100125820(olgc6)

OML:	112146531(gucy2c) 112154200(si:ch73-139e5.4)

CSAI:

133419697(gucy2cb) 133421390(gucy2ca)

XMA:	102222488 102228601

XCO:	114158534 114159907

XHE:	116727114 116735552

PRET:

103468453 103481041

PFOR:

103131082 103153414(gucy2c)

PLAI:

106951322 106961585

PMEI:

106904132 106930565

GAF:	122822183(gucy2ca) 122822810(gucy2cb)

PPRL:

129363837(gucy2ca) 129377870(gucy2cb)

CVG:	107089523 107093098(gucy2c)

CTUL:

119793772(si:ch73-139e5.4) 119799351(gucy2c)

GMU:	124862440 124863686 124875702(gucy2cb)

NFU:	107376314(gucy2c) 107395148

KMR:	108235883(si:ch73-139e5.4) 108236050(gucy2c)

ALIM:

106520689(gucy2c) 106532355

NWH:	119422127(gucy2ca) 119423906(gucy2cb)

AOCE:

111571297 111583570

MCEP:

124997243(gucy2ca) 125022262(gucy2cb)

CSEM:

103382072 103393320

POV:	109626894 109641080

SSEN:

122759184(gucy2cb) 122785880(gucy2ca)

HHIP:

117753420(si:ch73-139e5.4) 117766298(gucy2c)

HSP:	118100305(gucy2cb) 118123587(gucy2ca)

PPLT:

128426841(gucy2cb) 128458710(gucy2ca)

SMAU:

118287474(gucy2cb) 118288641(gucy2ca)

LCF:	108877661 108889117

SDU:	111219668 111239181

SLAL:

111646097 111673804

XGL:	120793937(gucy2cb) 120806797(gucy2ca)

HCQ:	109512274 109516411

SSCV:

125984098 125990860

SBIA:

133514364(gucy2ca)

PEE:	133395272(gucy2cb) 133415352(gucy2ca)

PTAO:

133466110(gucy2ca) 133469115(gucy2cb)

BPEC:

110159629 110162279(gucy2c)

MALB:

109952646

BSPL:

114846158(gucy2cb) 114860143(gucy2ca)

SJO:	128379063(gucy2ca) 128380989(gucy2cb)

SASA:

106589536 106601233 106607156 106609363

STRU:

115153591 115171297 115200030 115201328

OTW:	112224400 112226131 112258624 112258800

OMY:	110485178 110499093(si:ch73-139e5.4) 110502872 110538365

OGO:	124000310 124016063 124038528 124040155

ONE:	115110421 115110523 115112916 115144179

OKI:	109870303 109884384 109897350 109899995

OKE:	118365458 118372314 118384592 118402982

SALP:

111967904 111977979 112069941(gucy2c) 112072165

SNH:	120029440 120034573 120037803 120046769

CCLU:

121547468 121550926 121569015 121569023

ELS:	105025088 105025779(gucy2c)

SFM:	108926054 108940087

PKI:	111845199 111853175

AANG:

118216790(gucy2c) 118220888(si:ch73-139e5.4)

LOC:	102697444(gucy2c)

PSPA:

121306199

PSEX:

120536907(gucy2ca)

LCM:	102346928(GUCY2C)

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

LRJ:	133340989 133347587

» show all

Reference

PMID:1718270

Authors

Singh S, Singh G, Heim JM, Gerzer R

Title

Isolation and expression of a guanylate cyclase-coupled heat stable enterotoxin receptor cDNA from a human colonic cell line.

Journal

Biochem Biophys Res Commun 179:1455-63 (1991)
DOI:10.1016/0006-291X(91)91736-V

Sequence

[hsa:2984]

LinkDB

DBGET integrated database retrieval system