Danio rerio (zebrafish): 559017
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Entry
559017 CDS
T01004
Symbol
arhgef4
Name
(RefSeq) rho guanine nucleotide exchange factor 4 isoform X1
KO
K05769
Rho guanine nucleotide exchange factor 4/29
Organism
dre
Danio rerio (zebrafish)
Pathway
dre04810
Regulation of actin cytoskeleton
Brite
KEGG Orthology (KO) [BR:
dre00001
]
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
559017 (arhgef4)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
dre04131
]
559017 (arhgef4)
Membrane trafficking [BR:
dre04131
]
Others
Rho GTPase associated proteins
Rho guanine nucleotide exchange factors (GEFs)
559017 (arhgef4)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
RhoGEF
PH
SH3_1
SH3_2
SH3_9
DUF6470
Motif
Other DBs
NCBI-GeneID:
559017
NCBI-ProteinID:
XP_009296712
ZFIN:
ZDB-GENE-070912-575
Ensembl:
ENSDARG00000012914
UniProt:
A0A8M3B055
LinkDB
All DBs
Position
2:complement(16198735..16358991)
Genome browser
AA seq
3088 aa
AA seq
DB search
MDEAEAADGSGARGGELERPADGALDEVQMHLACLPERYMRAKFSLSAYIFCWTVVKLCQ
RLRPSLALPRAPALEDSGSEASCLEDGDSQQEECGEQQDHQEWCDPVSEAAQDTKEEYFD
THPWHSDTFSDSSHETKYCCRTSETGAVGHLDSHVSFVKPTPSARERDPSLAKRHHAVFD
SLSGTVDRVQLQTQTGNNKTMLMGVDGTKRECEEAFMNFPAGPGLDSSSTNDLSHVATPL
GDLKDSVELKIFPKPSAKDSLFTITDGCDEAELGGTFVSTSKWDQTSAQSKHSKPHMQFI
NSDKKELQQKDKSNMEIPLIPNPPVLKCAEAEHSELHSQHHKLNVDDTEISLSPSQHISV
YESLSFEKPVEQKVLSSEHSLHSVEHSQPQTSVEHSHPQISVEHSHPQISVEHSQPQISV
EHSQPQISVEHSQPQISVEHSQPQISVEHSQPQISVEHSQPQISVEHSQPQISVEHSHPQ
ISVEHSQPQISLEHSHPQISVEHSHPQISVEHSRTHMSVEHSQPQMLVEHNQPQMSVEHN
QPQMSVDHSQPQISVDHNQPQMSVDHSQPQISAEHRHSQMSVEHSQAQMSVDHSQPQMSV
GHSQSQISVEHSQPQISVEHSQPQISVEHSQPQMSAEHRQSQMSVEHSQPQMLVEHSQSQ
MSVEHSQSQMSVEHSQSQMSVEHSQPQMLVEHSQPQLFVEHSQSQNSADHSQSQASLNCS
QPQLSEEFRPSQDFVEHNQSNKTVDLNQSQDSVKHSQLQDTMEYSKTQASVEEVPTKHSQ
TENLVEDRQSQYSIEHRKSQTLVEDSPTHDFVELCQSGHLAEHSQSDCLIECSQSTNSVK
HSQSQDTAEHNQSEASVICSQSKNSIEHGPSQASVERSSQDFVEDSLEHSQSHDIAECIL
SQNVMEHSKSQVLDDDRPSQVYVGDNQSDKSVEVNISQDSEEDRSLTDFVVHSQSENSVE
HSQSQDLVEPRQSHDLIEHFKSLDNTEHKQSDMSYINCSQSQASVEILQSHESVEHSQSE
QSVKHSQSQDTDNFSQTQDLIKHSQSQTFIKCKHNQSLDGVQYDQSKILIEQTQSQDSVK
DNPSQDLVKHSQSQDTVEPSQSQVSVEHIQSQDSQDCSHSQNSTVHSQSQTSVGQSQSQD
LVEQSRSPAAAENSQSQTSVEHSQSLDSVEHMKSQTSVEHRQSQVELIKAHSMNTRWMVT
ESDTVAFYDKVRLKQDCMDVCADCEVVESLGVLSKHADNLNFENNERLNFKTQDLNDTSP
VVSEYECFPHVPNASSIGVPDSLHQCTISNSPSDLQVKTQQSWPVLQIHTEKDDYSVSRY
HMDGYCLQDSEQTEFYKTYQCPNSTINFNTQGEFTEARKVVSTEGVFTRGCINTKLFDGK
SVDIVGGPQKDSNKHHVMKGKECTIVPSIEQSVIYSDSSGCIEYKRPKTLSIACPDMTTA
ESEGCPVDSPVESLSTLFEIPHDRSTVSPTDICFEFSDGPHMNCTQVAQSVIEYSDAPKL
FHQFDTLSDKQRRPNESAEAIASNVDILSGARSDPFTNAQTPFDYSQVNSRNYTQSSDTN
NNIKAITLEECASGVQMSLPSSLQKYSRFTNNAECLVSKRGDYKNIDSFSARNTLATPFK
APEMKTEVNSRENVVKSSSHIDVTQRKLCDCCGGKECQLQTAGVFQFKGTDAISQRRTAV
LQTLSPLHTDDSTHEAVKVDSTSCEFSHMVSLLTHKHPNLVQEDFVLPLTGAHKADDTHV
LENMERKHETFPINALKSTESICETSDPLFKQTLQLHNSEVEGAFVSCCHILPITNLEAI
LETDRSPESSFAVENELDEQQRGSPLSEGGLNEDLSSCEDVKNRPHDSSCDMHTKANVAN
FMNEPDAGETMNSLSNGFDSSDDHSVSSLVSQDLDSSTNSEETEDTMQPSFGLRGNARNK
RTQSAKGSMFSGLIRMPTFRKPKRELKRNKNRVDPKVRASSGDGDEQDEMKNNRSPTCSK
SHSSLYKTPISQSADHLTDITKHSDHSNDDVFERAFALNVQNREKHMQPQHPFEQQQQKD
GDALSFRAGQTTEGLQQKRCKSIDNLNLRMKLALAHKSISSLFETRYPERDQEQILQLEN
EDGKTKQSWRKTKRCNEAELCKRTPVPGTVCDKCIHQSQIDCAFCAYQNRSILTNLPNVQ
ARLKNTCHSDPQSLKSAPQEGFEDGKYLEEGEQPCGAFSDSDQASVDGFESSVEDRSLSP
AHPTVLALSNQMSPTWTRSLSCFETTDTPTRPMSPKPHSPGLGWTQRRSFRYPSRSVASS
LCLLGQGVSTDGLLDPPQRPTSLKPRTTQLTTAHSFDSEYLLEDSSSDNQSQNSLNSASL
ISKTEHVQHITEAERRPQENACVLRVKSRDPGTAAPRPMSDLYGWTMSLQGTRELALDLE
RKTNAHQRSCSYETLTDVDNIRKKKLSKQQSLRQISTSTSERHEKLRARLSLTSPEQFPS
VPLKDHFFSQSTPVGLDYLGWAHRASFSETNLSAPEKEAHGQVAPLALVITDGPQDKSGL
ADEVGSEDDLYNEFRSSSNRFGHPGGGGEQLAINELISDGSVCAEALWDHVTMDDQELGF
KAGDVIEVVDATNKEWWWGRVLDSEGWFPASFVRLRVNQDEPMEEYLAHLDGASEGCGAS
MGGPLGPGLPCKEQMRANVINEIMSTERDYIKHLKDICEGYIKQCRKRTDMFTEEQLRTI
FGNIDELYRFQKKFLKALEKKFNKEHPHLSEIGSCFLEQQTNFQIYSEYCNNHPNACVQL
SKLMKIKKYVFFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTNPQHRDYK
DVEAALNAMKNVARLINERKRRLENIDKIAQWQSSIEDWEGEDVLSRSSDLIFSGDLTKI
SQPQAKGQQRMFFLFDHQLVFCKKDLLRRDILYYKGRLDMDEMEVVDVEDGKDKDFNVSV
KNALKLCSPGGEEVHLLCAKKPEQKQRWLRAFTDEREQVQHDLETGFTITEVQKKQAMLN
ATKSHPTGKPKALALQHLLALRAPLLHPKTKCLRLSEPPGPLVPRATLTSPLLPEGPQRR
QGRGVMVPPGVLRRAISWVSSQSREPIE
NT seq
9267 nt
NT seq
+upstream
nt +downstream
nt
atggacgaggcggaggctgcagacgggagcggagcgcggggcggtgaactcgagcgtccc
gctgacggagcgctggatgaggtgcagatgcatctcgcctgcttaccggagcgatacatg
agggcgaagttttccctctccgcgtacatattttgctggacagttgtgaagttgtgtcag
agattacgaccgtcgctggctcttcctcgggcccccgctttagaggactctgggagtgaa
gcaagctgtctggaggatggggactcccagcaggaggaatgtggagagcagcaggaccac
caggaatggtgtgatccggtttctgaagcagcacaggatacaaaagaagaatatttcgac
acacacccatggcacagtgacactttctctgactctagtcatgaaactaagtactgctgc
aggacctctgagactggtgctgtgggtcatctggactcacacgtttcatttgttaaaccc
acaccgtcagctagagagagagatccctctttagctaaacgccatcatgctgtctttgac
agtctcagtgggacagtggatagagtgcaattgcaaacacagacaggaaataacaaaacc
atgctcatgggagttgatggcactaaacgagaatgtgaggaggcttttatgaattttcca
gcaggacctggacttgattcttcttcaacgaatgacctatctcatgtagcaacaccccta
ggggatctaaaggactctgtagaactaaaaatattccccaagccaagtgctaaagactca
ttattcaccataacagatggatgtgatgaagccgagttagggggcacctttgtttcaaca
tcaaaatgggatcaaacaagtgctcagtcaaaacatagtaagccacacatgcagttcata
aactcagacaagaaagagttacagcaaaaggataaaagtaatatggaaataccattgatt
ccaaatccacctgttctgaaatgtgcagaagctgaacacagtgagttacacagtcaacat
cataagctaaatgttgatgacactgagatcagtttatctccatcacaacacatttctgta
tatgagtctttatcatttgagaagcctgttgaacagaaagttttatcatcagaacactca
cttcactcagtagagcacagccaaccacagacatcagtagagcacagccatccacagata
tcagtagagcacagccatccacagatatcagtagagcacagccaaccacagatatcagta
gagcacagccaaccacagatatcagtagagcacagccaaccacagatatcagtagagcac
agccaaccacagatatcagtagagcacagccaaccacagatatcagtagagcacagccaa
ccacagatatcagtagagcacagccaaccacagatatcagtagagcacagccatccacag
atatcagtagagcacagccaaccacagatatcattagagcacagccatccacagatatca
gtagagcacagccatccacagatatcagtagagcacagccgaacacatatgtcagtagag
cacagccaaccacagatgttagtagagcacaaccaaccacagatgtcagtagagcacaac
caaccgcagatgtcagtagaccacagccaaccacagatatcagtagaccacaaccaaccg
cagatgtcagtagaccacagccaaccacagatatcagcagagcacaggcattcacagatg
tcagtagagcacagccaagcacagatgtcagtagaccacagtcaaccacagatgtcagta
ggccacagtcaatcacagatatcagtagagcacagccaaccacagatatcagtagagcac
agccaaccacagatatcagtagagcacagccaaccacagatgtcagcagagcacaggcaa
tcacagatgtcagtagagcacagccaacctcagatgttagtagagcacagccaatcacag
atgtcagtagagcacagccaatcacagatgtcagtagagcacagccaatcgcagatgtca
gtagagcacagccaaccacagatgttagtagagcacagccaaccacagttatttgtagag
cacagccaatcacagaactctgctgatcacagccagtcacaagcttctttaaactgcagc
caaccacaactctcagaagaattcaggccatcacaagattttgttgaacacaaccaatca
aataaaactgtagatctcaaccagtcacaggattcagtaaaacacagtcagttgcaggat
acaatggaatacagtaaaacacaagcctcagtagaggaggttccaaccaaacacagccag
acagagaatttagtagaagacaggcaatcacagtattcaatagaacacagaaaatcacag
acattagtagaagacagtccaacacatgattttgttgaactttgtcaatcagggcactta
gcagaacacagccagtcagattgtttgatagaatgcagtcaatctacgaattcagttaaa
cacagccaatcacaggacacagcagagcacaaccaatcagaagcttctgtaatctgcagt
caatcaaagaattcaatagaacacggtccatcacaggcctcagtagagaggtcatcgcaa
gattttgttgaagactcactagaacacagtcagtcacatgatatcgcagagtgtattctg
tcgcaaaatgtaatggaacacagcaaatcacaagtcttagatgatgacaggccatcacaa
gtttatgttggagacaaccaatcagataaatctgtagaagtcaacatttcacaagattca
gaagaagacaggtcattaacagattttgtagtacacagccaatcagagaactcagtagaa
cacagccagtcacaggatttagtagaacctaggcaatcacatgatttaatagaacacttc
aaatcactagacaacacagagcacaagcaatcagacatgagttatataaactgcagtcaa
tcacaggcctcagtagaaatcttgcaatcacacgagtctgttgaacacagccaatcagaa
cagtcagtaaaacacagccagtcacaagacactgacaattttagccagacacaggattta
attaagcacagccaatcacagactttcataaaatgcaaacacaaccaatcactggatggc
gtacaatatgatcagtcaaagatcttaatagaacaaacccaatcacaggattccgtaaag
gacaatccatcccaagatcttgtcaaacatagccaatcacaggacacagtagaaccgagt
caatcacaggtctcagtagaacacatccaatcacaggattcccaagactgcagccattca
cagaactcaacagtacacagccaatcacaaacttcagtgggacaaagccaatcccaggat
ttggtagaacaaagtcgatcaccagctgcagccgaaaacagtcaatcacagacttcagtg
gaacacagccaatcactggattcagtggaacacatgaaatctcagacttcggtggaacac
aggcaatcacaggttgaattgattaaggcacattccatgaacacccggtggatggtgact
gagtcagacacagtagcgttttatgacaaggtgcgattaaaacaagactgcatggatgtt
tgcgcagattgtgaagtcgttgaatccttgggagttttatcaaaacatgctgacaatttg
aacttcgaaaataacgaaagactaaatttcaaaacacaggacttaaatgacacttcacct
gttgtttctgaatacgagtgtttcccacatgtgcctaatgcatcttctattggagtgcca
gattcactgcatcagtgcacgattagcaattcaccctcagacctgcaggttaaaactcag
cagagttggccagtattacaaatacacaccgaaaaagacgattactcagttagtaggtat
cacatggatggttactgtttgcaggacagtgagcaaacagagttttacaaaacctaccag
tgccctaacagtaccattaattttaatacacagggtgagttcactgaagctcggaaggtt
gtatcaactgaaggtgtatttactagaggttgtatcaacaccaaactttttgatggcaaa
agtgttgacattgtaggaggaccgcagaaggacagcaacaagcatcacgttatgaaaggg
aaagaatgtacaatagttccttcaatagagcagtcagtaatttactctgacagttcagga
tgcatagaatataaaaggcccaaaacgttgagcattgcttgtcctgacatgacgactgct
gaatctgaagggtgtcctgtagacagtcctgttgaatcactttctacactgtttgagatt
ccacatgacagatctacagtcagccccacagacatttgctttgagtttagtgatggccct
catatgaactgtacacaagtagcacagagtgttatagaatattcagatgcccccaaacta
tttcaccagtttgacaccctgtctgacaaacaaagaagacctaatgagtcagctgaagca
attgcgtcgaatgttgatattttgtctggtgcacgttccgatcctttcacaaatgcacag
actccttttgattattcccaggtgaacagcaggaactatacacagagctcagacacaaat
aataacattaaagccattactttagaagagtgtgcctcgggagtacaaatgtcattgcct
agttcattgcagaaatacagtaggtttacaaataatgctgaatgcttagtctcaaaaagg
ggtgattacaaaaacattgattcttttagtgctcgtaatactctggctacccccttcaaa
gcacctgaaatgaagactgaagtgaacagcagagaaaatgttgtgaaatctagcagtcac
atagatgttacacagaggaagctctgtgattgctgcggtggaaaggagtgccagctgcag
acagcgggtgtatttcagttcaagggcacagacgccatcagtcagcgcagaactgcagtg
ttgcaaaccttgagtcccctccacacagatgacagcacacatgaagcggtaaaagtagac
tctacaagctgtgaattttcacatatggtcagtttgcttacacacaaacatccgaatctt
gtccaagaagacttcgtattaccactgactggagctcataaggctgatgatactcatgta
ttagaaaacatggagagaaagcatgaaactttcccaataaatgctcttaaaagcactgaa
tcaatatgtgaaacttctgatcctctttttaagcaaacattgcaattgcacaactcggag
gttgagggcgcatttgtttcatgttgtcatattttgcccatcaccaacttagaggccatt
ttagagacggaccgttccccggagagctcatttgcagtagaaaatgaactggatgagcaa
cagagaggaagtcctttatcagaaggtggattaaatgaggacctaagctcttgtgaggat
gtcaaaaaccgcccacatgacagcagttgtgatatgcatacaaaagccaatgtagccaat
ttcatgaatgaacccgatgctggagaaacaatgaactctttatcaaatgggtttgacagc
agtgatgaccatagtgtttccagtttggtgtcacaagaccttgactccagtaccaacagt
gaggagacggaagacaccatgcagccatcgtttggtcttcgtggtaatgcgagaaataaa
agaacacagtcagccaagggctctatgttttctggtttgattcgaatgcccaccttccgc
aagccaaaacgagaactcaaacgcaataaaaacagggttgatccgaaagttagggcatcc
agtggggatggagatgaacaagatgagatgaagaacaacaggtcacccacatgcagcaaa
tctcactcttcactgtacaagacccctatatctcaaagtgcagatcaccttactgatatt
acaaagcattctgaccactcaaatgatgatgtttttgaaagggcttttgctttaaatgtg
caaaatagagagaaacacatgcaacctcaacacccgtttgagcagcagcagcagaaagat
ggagatgcactcagttttagagctggccagacaacagaggggttgcaacaaaaaagatgc
aagagcattgataacttaaacttacgcatgaagctggcattggctcacaagtctatttct
agcctgtttgagaccagatatcctgagagggaccaagagcaaatcttacagttagagaat
gaggatgggaaaaccaagcaatcatggagaaagaccaaacgatgtaacgaagcagaactt
tgcaaaagaactcctgttcctgggacggtctgtgacaagtgcatacatcagagccaaatt
gattgtgccttctgtgcttatcagaaccggtccatattaaccaacttaccaaatgtccaa
gcaagattgaagaacacgtgccattctgacccgcagagtttgaaatctgcacctcaggaa
gggtttgaagatggtaaatatctggaggaaggtgagcagccttgtggtgctttctcagat
tcagaccaagcatcggtagatggttttgagtccagtgtagaggacaggtcgctgtcacct
gcacaccccactgttcttgcactttcaaaccaaatgtcacctacctggacaaggtcccta
agctgcttcgagacaactgatacaccgacaaggcccatgagccccaaaccacacagtcct
ggtctgggctggacacagcggaggagcttccgctacccctcaagatctgttgcatcttct
ctctgcttgcttggtcagggagtgagcactgacggtctcttagacccacctcagaggccg
acatctctaaaaccaaggacaacacaactcaccacagctcactccttcgattctgagtac
ttactggaggacagcagttcagacaaccagtctcagaatagcctgaattcagcctccctg
atcagcaaaacagagcatgtacagcacattactgaagcagagagaagaccacaagaaaat
gcatgtgtgcttcgggtgaagtccagagatccaggtacagctgcgcccaggcctatgtca
gacctgtacggctggaccatgtctcttcagggcaccagagagttggcgctcgacttggag
aggaagactaacgcacatcagcgctcatgctcatatgaaacattgaccgatgtggataac
atccgcaaaaagaagctaagcaagcagcaaagtttgcggcagattagcacatcaacatct
gagaggcatgagaaattgcgagctagactttccctcacatccccggagcagttcccctct
gttcctctcaaagaccacttcttctctcagagcacacctgttgggctggactatctgggc
tgggctcaccgtgcatccttttcagaaacgaacctcagcgcaccggaaaaagaggcacat
ggacaggtcgcacctctcgcattggtgataactgatgggccacaggataagtctggtctt
gcagatgaggtgggcagtgaagatgatctgtacaatgaattccgcagctcctccaaccga
ttcggacacccaggaggaggaggagaacagctggccataaatgagctgatcagtgatggc
agtgtgtgcgcggaggctctatgggaccacgtcaccatggatgaccaggagctgggcttt
aaagctggagatgtcattgaagtagtggacgctacgaacaaggagtggtggtggggcagg
gtgctggacagcgagggctggttccccgccagctttgttcggttacgggtgaaccaagat
gagcccatggaggaatacctagcccatctggacggggcctcagaggggtgtggggccagc
atggggggacccttgggacctggactgccatgcaaggagcagatgagagccaacgtcatc
aatgagatcatgagcacagagagagattacattaaacacctgaaggacatatgtgagggc
tatataaaacaatgtcggaagaggacagatatgtttacagaagagcaactgcgcactatc
tttggcaacatcgacgagctctaccgattccagaagaagttcctcaaagccttggagaaa
aaattcaacaaagagcatcctcacctcagcgagatcggctcctgcttcttagagcagcaa
acaaacttccagatctattctgagtattgcaacaaccaccccaatgcctgcgtgcagctc
tccaaactgatgaagatcaagaagtatgtgttcttctttgaggcttgtcgcctgctccag
aagatgattgacatttcgttggatggattcctacttactcctgttcagaagatctgcaag
tatcctctgcagctcgctgaactgctcaagtacaccaacccacagcacagagattataag
gatgtggaagctgccttaaacgctatgaagaatgtggccagactgatcaatgagagaaag
aggcgtctagaaaatattgacaaaatcgctcagtggcagagctccatagaagactgggag
ggtgaagacgtcttgagcaggagctctgatctgatcttttctggagacctgaccaagatc
tcccagccacaggctaaaggccagcagagaatgttcttcctctttgaccaccaactggtt
ttctgtaagaaggatctgcttcggagggatatcttgtactacaagggtcggttagacatg
gatgagatggaggtggtggatgtggaggatgggaaggataaggactttaatgtgagtgtg
aagaatgccttgaaattgtgttctcctggaggagaggaggttcatctcctgtgtgccaag
aagcccgaacaaaagcagcgctggctgagagccttcacagatgagcgggagcaggtccag
catgacctcgagacaggttttacgattacagaggtccagaagaagcaggcaatgttgaat
gcaactaagagtcatccaacagggaagcctaaagcattagctttacagcaccttttggca
ctcagagctccactccttcaccccaaaaccaagtgcctgcgtttgtccgagcctccagga
cctctggttcccagggccaccctaacttcacctctcctccctgaagggcctcagcgcagg
caggggcggggggttatggtgccccctggggtcctgcgcagggctatatcctgggtctcc
tctcaaagtagagagcccatcgagtag
DBGET
integrated database retrieval system
