ENZYME: 1.1.1.185
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Entry
EC 1.1.1.185 Enzyme
Name
L-glycol dehydrogenase;
glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase;
L-(+)-glycol:NAD(P)+ oxidoreductase;
L-glycol:NAD(P)+ dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-glycol:NAD(P)+ oxidoreductase
Reaction(IUBMB)
an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+ [RN:
R03584
R03585
]
Reaction(KEGG)
R03584
R03585
Reaction
Substrate
L-glycol [CPD:
C01506
];
NAD+ [CPD:
C00003
];
NADP+ [CPD:
C00006
]
Product
2-hydroxycarbonyl compound [CPD:
C03667
];
NADH [CPD:
C00004
];
NADPH [CPD:
C00005
];
H+ [CPD:
C00080
]
Comment
The 2-hydroxycarbonyl compound formed can be further oxidized to a vicinal dicarbonyl compound. In the reverse direction, vicinal diketones, glyceraldehyde, glyoxal, methylglyoxal, 2-oxo-hydroxyketones and 2-ketoacid esters can be reduced.
History
EC 1.1.1.185 created 1984
Reference
1 [PMID:
7018582
]
Authors
Bernardo A, Burgos J, Martin R.
Title
Purification and some properties of L-glycol dehydrogenase from hen's muscle.
Journal
Biochim Biophys Acta 659:189-98 (1981)
DOI:
10.1016/0005-2744(81)90283-7
Other DBs
ExplorEnz - The Enzyme Database:
1.1.1.185
IUBMB Enzyme Nomenclature:
1.1.1.185
ExPASy - ENZYME nomenclature database:
1.1.1.185
BRENDA, the Enzyme Database:
1.1.1.185
CAS:
77967-75-0
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