KEGG ENZYME: 1.1.1.197

ENZYME: 1.1.1.197

Entry

EC 1.1.1.197 Enzyme

Name

15-hydroxyprostaglandin dehydrogenase (NADP+);
NADP-dependent 15-hydroxyprostaglandin dehydrogenase;
NADP-linked 15-hydroxyprostaglandin dehydrogenase;
NADP-specific 15-hydroxyprostaglandin dehydrogenase;
type II 15-hydroxyprostaglandin dehydrogenase;
15-hydroxyprostaglandin dehydrogenase (NADP)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase

Reaction(IUBMB)

(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP+ = (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH + H+ [RN:R04552]

Reaction(KEGG)

R04552

Substrate

(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate [CPD:C04741];
NADP+ [CPD:C00006]

Product

(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate [CPD:C04654];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin D2 [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC 1.1.1.189 prostaglandin-E2 9-reductase.

History

EC 1.1.1.197 created 1984

Orthology

K00079

carbonyl reductase 1

Genes

HSA:

873(CBR1)

PTR:	473983(CBR1)

PPS:	100984486(CBR1)

GGO:	101128365(CBR1)

PON:	100172097(CBR1)

NLE:	100595150(CBR1)

MCC:

699655

MCF:	102141127(CBR1)

CSAB:

103218526(CBR1)

RRO:

104680046

RBB:	108536876(CBR1)

CJC:	100385429(CBR1)

SBQ:	101053953(CBR1)

MMU:	12408(Cbr1)

MCAL:

110288679 110311495 110311943

MPAH:

110329855 110329915

RNO:	100360601 102556347 108348130 29224(Cbr1)

MUN:

110553070

CGE:	100689019(Chcr1) 100689020(Chcr2) 100752270 100753466 113835641

NGI:	103736428(Cbr1)

HGL:	101707305 101709698

CCAN:

109685204 109685205

OCU:	100009528(CBR1) 100344189 100344439 100344692 100344949 100345202 100345459 100345716 100348029 100348276

TUP:	102493488(CBR1)

CFA:	100688446 478411 480785 610164

VVP:	112910256 112910259 112910262 112910266

AML:	100463727 100482421 100482670

UMR:	103673139 103673143 103673144(CBR1) 103673226 103673227 103673228

UAH:	113260781 113260850

ELK:	111155701 111155789

FCA:	101083875 101084134 101084388 102901316 105260891

PTG:	102951798 102962462 102963221 107180402

PPAD:

109249662 109249663 109249756 109249757 109249758 109249759 109249762 109249763 109249764

AJU:	106966975 106966977 106966978 106966979 106967000 106967001

BTA:	112441473 510180(MGC127133) 515946(CBR1)

BOM:	102280157 102280721

BIU:	109561438 109561446 109561452 109564723

BBUB:

102389721 102414811 102415914 112577647 112577706 112577717 112586983 112586984

CHX:	102172669 102178311 108633281

OAS:	101114408 101114663 101115172 114110594

SSC:	100622246 110256480 110256481 110256483 397143(CBR1)

CFR:

102513911

CDK:

105089844

BACU:

103007396

LVE:	103084663(CBR1)

OOR:	101289691(CBR1)

DLE:

111163852

PCAD:

102979665

ECB:	100061592 100061622 100061690 100061787 100630657

EPZ:	103548815 103548838

EAI:	106831418 106831423

MYB:	102242410 102242716 106723568

MYD:	102773942(CBR1)

MNA:

HAI:

DRO:

PALE:

RAY:

MJV:	108386803 108396123 108396124 108396125 108405052(CBR1) 108405883 108408249

LAV:	100665833 100666118 100674470

TMU:

101361316

MDO:	100015103 100015187 100015233

SHR:

100920969

PCW:	110214859 110214881 110214882 110214894

OAA:

100081857

GGA:	418512(CBR1)

MGP:	100550018(CBR1)

CJO:

NMEL:

APLA:

ACYG:

TGU:

LSR:

SCAN:

103815738(CBR1)

GFR:	102043656(CBR1)

FAB:	101809650 101821429(CBR1)

PHI:	102114609(CBR1)

PMAJ:

107211649

CCAE:

111928724

CCW:

104696752

ETL:	114070969 114071875

FPG:	101915985(CBR1)

FCH:

CLV:

EGZ:

NNI:

ACUN:

PADL:

AAM:

ASN:

AMJ:	102575087(CBR1)

PSS:

102454231

CMY:	102945673 102946220

CPIC:

101937374(CBR1)

ACS:	100567688 100568150

PVT:	110076821 110076832

PBI:

PMUR:

TSR:

PMUA:

GJA:

XLA:	108707866 108707867 108707868 496039 734804(cbr1.S)

XTR:	100145008(cbr1.3) 101735101(cbr1.2) 496612(cbr1.1)

NPR:	108791095 108791096

DRE:	337696(cbr1l) 373866(cbr1) 792137

SRX:	107706524 107746284

SANH:

107676886(cbr1) 107681174 107692178

SGH:	107560976 107573060 107589305

CCAR:

109096114(cbr1)

IPU:	108258607(cbr1) 108279390

PHYP:

113537332(cbr1) 113541450

AMEX:

103025086(cbr1) 103044035 103044320

EEE:

113577487

TRU:	101070504(cbr1)

TNG:	GSTEN00018781G001

LCO:	104925597(cbr1)

MZE:	101465189 101465758(cbr1) 101466994 101467487

ONL:	100534432 100694465 100694734 100694993

OLA:	100125494(cbr1)

XMA:	102228388(cbr1) 102228648

XCO:	114137930 114137931

PRET:

103476570 108166972

CVG:

107105240

NFU:	107376130 107376131(cbr1)

KMR:	108250748 108250751

ALIM:

106527744(cbr1)

AOCE:

111579487 111579488 111579490

CSEM:

103387805(cbr1)

POV:	109644021(cbr1)

LCF:	108872922(cbr1)

SDU:	111223859(cbr1)

SLAL:

111645450(cbr1)

HCQ:	109510228 109515209

BPEC:

110156802 110156828 110156944 110171218 110175574

MALB:

109963832(cbr1)

SASA:

106563564(DHCA) 106563565(DHCA) 106563632 106575082(cbr1) 106586631

OTW:	112231245 112231246 112240976 112253987(cbr1)

SALP:

111964260 111979044 112068582(cbr1)

ELS:	105010857 109614572(cbr1)

SFM:	108924735 108938298

PKI:	111835840 111837929

LCM:	102349061 102367136(CBR1)

CMK:	103186742 103186743

RTP:	109933230(cbr1)

BFO:	118406581 118415952 118423977 118423978 118423979 118423980 118423984 118432795

CIN:

100182286

SPU:	100889317 100892458 105447311 115926118 115926133 574551 574612 579824 592403

APLC:

110973484 110973485 110973486

SKO:	100366455 100366603 100366755 100367363 100367671 100372039

AME:

BIM:

BTER:

SOC:

MPHA:

AEC:	105144039 105150971

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

PCF:

TCA:

DPA:	109534143 109543822

ATD:	109597522 109597585

NVL:

108565934

BMOR:

101741781 101741955 101742796 101745818

BMAN:

114240454 114247724 114248343 114248943 114251689

DPL:	KGM_201906 KGM_201907 KGM_203730 KGM_205942 KGM_211104

PMAC:

106710022 106711291 106711292 106711293 106712788 106712790 106718276 106718996 106719907 106719988

PRAP:

110991285 110994263 110999668 111000881 111000883 111000886 111000894 111000902 111001155 111001160 111002340 111004489

HAW:	110369634 110371928 110372428 110372664 110374859 110376990 110376991 110381163

TNL:	113493465 113494468 113497934 113497936 113501185 113501186 113504446

PXY:	105381161 105382647 105382918 105384073 105384527 105389704

API:	100573774 103310702

DNX:

AGS:

RMD:

CLEC:

ZNE:

FCD:	110844332 110844333 110855694

DPX:	DAPPUDRAFT_231053 DAPPUDRAFT_301515 DAPPUDRAFT_303686

PVM:	113803519 113803522 113827259

ISC:	IscW_ISCW014791

TUT:

107369493

CSCU:

111618019 111618020 111618039 111618040

PTEP:

107443485 107443486 107443500 107449444 107449445 107449446

BMY:

Bm1_44405

HRO:	HELRODRAFT_70715

LGI:	LOTGIDRAFT_191692

PCAN:

112560870 112560871

CRG:	105317039 105323458 105325714 105325969 105340670

MYI:	110449544 110449545 110449546 110458931 110466215 110466238 110466244 110466251

OBI:

106869220

SMM:	Smp_033530.1 Smp_033540 Smp_140270

SHX:	MS3_09619 MS3_09620

OVI:	T265_10122 T265_13980

EGL:	EGR_04035 EGR_04036 EGR_04038 EGR_04039

NVE:	5509101 5521730

EPA:	110245171 110252725 110254732

ADF:	107331745 107355632 107355635

AMIL:

114955216 114965043

PDAM:

113670231 113670238 113670240

SPIS:

111327394 111327400 111327401

DGT:	114523105 114527152

HMG:	100200320 100209766 100215805

AQU:

100637791

ATH:	AT3G59710 AT5G51030 AT5G61830

ALY:	9301912 9302530 9312590

CRB:	17875908 17876819 17885946

CSAT:

104699947 104725607 104739243 104749372 104752647 104761093 104762305 104788224

EUS:	EUTSA_v10004629mg EUTSA_v10006128mg EUTSA_v10014119mg

BRP:	103831402 103841820 103857252 103873463

BNA:	106347765 106356807 106365086 106386538 106386868 106405534 106421946

BOE:	106299694 106311381 106333536 106335608

RSZ:	108816710 108847990 108860585 108863207

THJ:	104801760 104804113 104825040

CPAP:

110820325 110821336

CIT:	102618831 102626275

CIC:	CICLE_v10021349mg CICLE_v10032162mg

TCC:	18602340 18605222

GRA:	105778476 105789862 105802135

GHI:	107888022 107896776 107912060 107914599 107950819

GAB:	108458604 108477329 108488644

DZI:	111290989 111307228 111318032

EGR:	104416142 104427637

GMX:	100790340 100793649 100795540 100801160 100811138 100813783 100814467

GSJ:	114389247 114410892 114411566 114414083 114421948 114425636

PVU:	PHAVU_002G280700g PHAVU_003G033300g PHAVU_003G060100g

VRA:	106765992 106768075 106777158

VAR:	108323779 108335170 108337975

VUN:	114169512 114178882 114179349

CCAJ:

109791749 109791751 109805547 109813662 109813686 109815595

MTR:	MTR_1g031180 MTR_3g098470 MTR_4g087460 MTR_8g096060

CAM:	101490621 101500438 101502987 101507622

LJA:	Lj1g3v4457750.1(Lj1g3v4457750.1) Lj2g3v0126340.1(Lj2g3v0126340.1) Lj4g3v0510200.1(Lj4g3v0510200.1)

ADU:	107458870 107463386 107480845

AIP:	107612497 107613511 107634669

LANG:

109326482 109337255 109340831 109340991 109349784 109361997 109362223

FVE:	101295293 101306684 105351700

RCN:	112180155 112199948

PPER:

18776141 18794041

PMUM:

103323393 103344208

PAVI:

110763930 110769636

MDM:	103418483 103420529 103438784 103454871

PXB:	103931301 103933612 103933613 103962644

ZJU:	107406898 107423505

CSV:	101205654 101215260

CMO:	103488873 103502267

MCHA:

111007240 111019666

CMAX:

111466403 111485563 111493032 111496416

CMOS:

111430094 111438126 111449752 111458888

CPEP:

111780719 111792674 111801381 111802198

RCU:	8275476 8286374

JCU:	105636688 105648706

HBR:	110633828 110658924 110658943 110659712

MESC:

110615156 110616640

POP:	18104597 7457587 7484898

PEU:	105134607 105136586 105138578

JRE:	109000478 109005804 109021483

QSU:	111989944 111997451 112000575 112022063 112029133 112034324

VVI:	100254495 100264726

SLY:	101244166 101244566 101250605 101263291

SPEN:

107006389 107013752 107014799 107023668

SOT:	102584474 102587809 102604350

CANN:

107865865 107866302 107875989

NTA:	107769189 107772180 107780469 107781563 107793914 107810410 107820627 107821771

NSY:	104217663 104220950 104221924 104234288

NTO:	104092916 104099524 104101805 104106235

NAU:	109210588 109228161 109239914 109241815

INI:	109156765 109163117 109165567 109189929

SIND:

105158283 105165498 105172075

OEU:	111372333 111391789 111393011 111394068 111400575

HAN:	110883647 110911119 110917661 110939842

LSV:	111885945 111896716

CCAV:

112510112 112511454 112514227 112519910

DCR:	108195668 108220398 108220469

BVG:	104889015 104898560 104908343

SOE:	110774690 110780494 110785380 110797137

CQI:	110698550 110704321 110709284 110717863 110738715

NNU:	104586992 104598224 104602854

PSOM:

113271415 113281310 113284641 113317971

OSA:	4326939 4329932 4336277

DOSA:

Os01t0929500-01(Os01g0929500) Os02t0607700-01(Os02g0607700) Os04t0496000-01(Os04g0496000) Os04t0496150-00(Os04g0496150)

OBR:	102715443 102718517 102720045

BDI:	100836851 100843489 100844524

ATS:	109744526(LOC109744526) 109758873(LOC109758873) 109764067(LOC109764067)

SBI:	8056507 8059399 8075877

ZMA:	100194367 100383092 100383687 103653744

SITA:

101764764 101766964 101768330

PDA:	103716007 103721881

EGU:	105035155 105051634

MUS:	103981762 103995983

DCT:	110095551 110104782

PEQ:	110028663 110035110 110037942

AOF:	109824737 109826236 109830212

ATR:	18434512 18448661

SMO:

SELMODRAFT_107407 SELMODRAFT_110901 SELMODRAFT_111807 SELMODRAFT_112611 SELMODRAFT_112669 SELMODRAFT_117556 SELMODRAFT_126117 SELMODRAFT_138880 SELMODRAFT_143767 SELMODRAFT_173170 SELMODRAFT_270248 SELMODRAFT_271526 SELMODRAFT_271617 SELMODRAFT_404603 SELMODRAFT_419963 SELMODRAFT_443296 SELMODRAFT_78232 SELMODRAFT_78745 SELMODRAFT_83967

PPP:	112277466 112281434 112289080 112294581

CRE:	CHLREDRAFT_159999

VCN:	VOLCADRAFT_121544

MNG:	MNEG_0762 MNEG_10981 MNEG_6744 MNEG_6963 MNEG_6964

CSL:	COCSUDRAFT_55771

CME:	CYME_CMR042C

GSL:	Gasu_14740 Gasu_24590

CCP:	CHC_T00006708001

TTT:	THITE_2124387

MTM:	MYCTH_2308099

VAL:	VDBG_02730

VDA:	VDAG_03647

CFJ:	CFIO01_05935

SAPO:

SAPIO_CDS1598

GLZ:	GLAREA_06959

PCS:	Pc22g08240

PNO:	SNOG_02806

PTE:	PTT_09714 PTT_15556

BZE:	COCCADRAFT_31994 COCCADRAFT_38538

BSC:	COCSADRAFT_105489 COCSADRAFT_347261

BOR:	COCMIDRAFT_39676 COCMIDRAFT_81758

AALT:

CC77DRAFT_1013598

ZTR:	MYCGRDRAFT_36990

PFJ:	MYCFIDRAFT_100760 MYCFIDRAFT_41956

BCOM:

BAUCODRAFT_37592 BAUCODRAFT_393649

TML:	GSTUM_00010330001

SHS:	STEHIDRAFT_98222

ADL:	AURDEDRAFT_115777 AURDEDRAFT_115778 AURDEDRAFT_170147

GTR:	GLOTRDRAFT_136682

MRR:	Moror_6831

SCM:	SCHCODRAFT_53501

UMA:	UMAG_01815

PFP:	PFL1_02949

SRE:	PTSG_00844 PTSG_09068 PTSG_09069

ACAN:

ACA1_172860 ACA1_172870 ACA1_362920

TGO:	TGME49_290890

TET:	TTHERM_00187260 TTHERM_00557790

PTM:	GSPATT00013734001 GSPATT00033729001

SMIN:

v1.2.012697.t1(symbB.v1.2.012697.t1) v1.2.027692.t1(symbB.v1.2.027692.t1) v1.2.038435.t1(symbB.v1.2.038435.t1)

FCY:	FRACYDRAFT_248070 FRACYDRAFT_261152

AAF:	AURANDRAFT_20875 AURANDRAFT_58590

EHX:	EMIHUDRAFT_100056 EMIHUDRAFT_106817 EMIHUDRAFT_114810 EMIHUDRAFT_198354 EMIHUDRAFT_199868 EMIHUDRAFT_231395 EMIHUDRAFT_239732 EMIHUDRAFT_240561 EMIHUDRAFT_250847

GTT:	GUITHDRAFT_117185

NGR:	NAEGRDRAFT_46325

HALC:

EY643_09830

AGE:	AA314_02253

CFUS:

CYFUS_001424

SCU:	SCE1572_17400 SCE1572_20305

CCRO:

CMC5_043940

SAMY:

DB32_006871

LLU:	AKJ09_08245

MRM:	A7982_03611

HOH:	Hoch_4302 Hoch_6753

PCAY:

FRD00_05770

MMAG:

MMAD_15640

NSR:	NS506_05239(cbr1)

NOZ:	DMB37_24865

SVL:	Strvi_3397

SBH:

SBI_00264

SHY:

SHJG_1150

SHO:	SHJGH_0985

SCI:	B446_03320

SALU:

DC74_1011

SALL:

SAZ_05530

SCX:	AS200_41755

SNZ:	DC008_34805

KQI:	F1D05_27355

NOA:	BKM31_30545

SSYI:

EKG83_20765

KAL:

KALB_4608

KPHY:

AOZ06_14020

LED:	BBK82_26850

KBS:	EPA93_36485

» show all

Reference

1 [PMID:234431]

Authors

Lee SC, Levine L.

Title

Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types.

Journal

J Biol Chem 250:548-52 (1975)

Reference

2 [PMID:803247]

Authors

Lee SC, Pong SS, Katzen D, Wu KY, Levine L.

Title

Distribution of prostaglandin E 9-KETOREDUCTASE AND TYPES I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex.

Journal

Biochemistry 14:142-5 (1975)
DOI:10.1021/bi00672a024

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.197

IUBMB Enzyme Nomenclature:

1.1.1.197

ExPASy - ENZYME nomenclature database:

1.1.1.197

BRENDA, the Enzyme Database:

1.1.1.197

CAS:	54989-39-8

LinkDB

DBGET integrated database retrieval system