KEGG ENZYME: 1.1.1.197

ENZYME: 1.1.1.197

Entry

EC 1.1.1.197 Enzyme

Name

15-hydroxyprostaglandin dehydrogenase (NADP+);
NADP-dependent 15-hydroxyprostaglandin dehydrogenase;
NADP-linked 15-hydroxyprostaglandin dehydrogenase;
NADP-specific 15-hydroxyprostaglandin dehydrogenase;
type II 15-hydroxyprostaglandin dehydrogenase;
15-hydroxyprostaglandin dehydrogenase (NADP)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase

Reaction(IUBMB)

(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP+ = (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH + H+ [RN:R04552]

Reaction(KEGG)

R04552

Substrate

(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate [CPD:C04741];
NADP+ [CPD:C00006]

Product

(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate [CPD:C04654];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Acts on prostaglandins E2, F2alpha and B1, but not on prostaglandin D2 [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC 1.1.1.189 prostaglandin-E2 9-reductase.

History

EC 1.1.1.197 created 1984

Orthology

K00079

carbonyl reductase 1

Genes

HSA:

873(CBR1)

PTR:	473983(CBR1)

PPS:	100984486(CBR1)

GGO:	101128365(CBR1)

PON:	100172097(CBR1)

NLE:	100595150(CBR1)

MCC:

699655

MCF:	102141127(CBR1)

CSAB:

103218526(CBR1)

RRO:	104680046(CBR1)

RBB:	108536876(CBR1)

CJC:	100385429(CBR1)

SBQ:	101053953(CBR1)

MMU:	12408(Cbr1)

MCAL:

110288679 110311495 110311943

MPAH:

110329855 110329915

RNO:	102556347 29224(Cbr1)

MUN:

110553070

CGE:	100689019(Chcr1) 100689020(Chcr2) 100752270 100753466 113835641

NGI:	103736428(Cbr1)

HGL:	101707305 101709698

CCAN:

109685204 109685205

OCU:	100009528(CBR1) 100344189 100344439 100344692 100344949 100345202 100345459 100345716 100348029 100348276

TUP:	102493488(CBR1)

CFA:	478411 480785 610164

VVP:	112910256 112910259 112910262 112910266

AML:	100463727 100482421(CBR1)

UMR:	103673139 103673143 103673144(CBR1) 103673226 103673227 103673228

UAH:	113260781 113260850

FCA:	101083875 101084134 101084388 102901316 105260891

PTG:	102951798 102962462 102963221 107180402

PPAD:

109249662 109249663 109249756 109249757 109249758 109249759 109249762 109249763 109249764

AJU:	106966975 106966977 106966978 106966979 106967000 106967001

BTA:	510180(MGC127133) 515946(CBR1)

BOM:	102280157 102280721

BIU:	109561438 109561446 109561452 109564723

BBUB:

102389721 102415914 112577706 112586983 112586984

CHX:	102172669 102178311 108633281

OAS:	101114408 101114663 101115172

SSC:	100622246 397143(CBR1)

CFR:	102513911(CBR1)

CDK:

105089844

BACU:

103007396

LVE:	103084663(CBR1)

OOR:	101289691(CBR1)

DLE:

111163852

PCAD:

102979665

ECB:	100061622 100061690 100061787 100630657

EPZ:	103548815 103548838

EAI:	106831418 106831423

MYB:	102242410 102242716 106723568

MYD:	102773942(CBR1)

MNA:

HAI:

DRO:

PALE:

RAY:

MJV:	108386803 108396123 108396124 108396125 108405052(CBR1) 108405883 108408249

LAV:	100665833 100666118 100674470

TMU:	101341292 101361316

MDO:	100015103 100015187 100015233

SHR:

100920969

PCW:	110214859 110214881 110214882 110214894

OAA:

100081857

GGA:	418512(CBR1)

MGP:	100550018(CBR1)

CJO:

NMEL:

APLA:

ACYG:

TGU:

LSR:

SCAN:

103815738(CBR1)

GFR:	102043656(CBR1)

FAB:	101809650 101821429(CBR1)

PHI:	102114609(CBR1)

PMAJ:

107211649

CCAE:

111928724

CCW:

104696752

ETL:	114070969 114071875

FPG:	101915985(CBR1)

FCH:

CLV:

EGZ:

NNI:

ACUN:

PADL:

AAM:

ASN:

AMJ:	102575087(CBR1)

PSS:

102454231

CMY:	102945673 102946220

CPIC:

101937374(CBR1)

ACS:	100567688 100568150

PVT:	110071457 110076821 110076832

PBI:

PMUR:

TSR:

PMUA:

GJA:

XLA:	108707866 108707867 108707868 496039 734804(cbr1.S)

XTR:	100145008(cbr3) 101735101 496612(cbr1)

NPR:	108791095 108791096

DRE:	337696(cbr1l) 373866(cbr1)

SRX:	107706524 107746284

SANH:

107676886(cbr1) 107681174 107692178

SGH:	107560976 107573060 107589305

CCAR:

109096114(cbr1)

IPU:	108258607(cbr1) 108279390

PHYP:

113537332(cbr1) 113541450

AMEX:

103025086(cbr1) 103044035 103044320

EEE:

113577487

TRU:	101070504(cbr1)

TNG:	GSTEN00018781G001

LCO:	104925597(cbr1)

NCC:

104949102

MZE:	101465189 101465758(cbr1) 101466994 101467487

ONL:	100534432 100694465 100694734 100694993

OLA:	100125494(cbr1)

XMA:	102228388(cbr1) 102228648

XCO:	114137930 114137931

PRET:

103476570 108166972

CVG:

107105240

NFU:	107376130 107376131(cbr1)

KMR:	108250748 108250751

ALIM:

106527744(cbr1)

AOCE:

111579487 111579488 111579490

CSEM:

103387805(cbr1)

POV:	109644021(cbr1)

LCF:	108872922(cbr1)

SDU:	111223859(cbr1)

SLAL:

111645450(cbr1)

HCQ:	109510228 109515209

BPEC:

110156802 110156828 110156944 110171218 110175574

MALB:

109963832(cbr1)

SASA:

106563564(DHCA) 106563565(DHCA) 106563632 106575082(cbr1) 106586631

OTW:	112231245 112231246 112240976 112253987(cbr1)

SALP:

111964260 111979044 112068582(cbr1)

ELS:	105010857 109614572(cbr1)

SFM:	108924735 108938298

PKI:	111835840 111837929

LCM:	102349061 102367136(CBR1)

CMK:	103186742 103186743

RTP:	109933230(cbr1)

BFO:	BRAFLDRAFT_118600 BRAFLDRAFT_118601 BRAFLDRAFT_133204 BRAFLDRAFT_261426 BRAFLDRAFT_274685 BRAFLDRAFT_59475

CIN:

100182286

SPU:	574612 590243

APLC:

110973484 110973485

SKO:	100366455 100366603 100366755 100367363 100367671 100372039

AME:

BIM:

BTER:

SOC:

MPHA:

AEC:	105144039 105150971 105151007

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

PCF:

TCA:

DPA:	109534143 109543822

ATD:	109597522 109597585

NVL:

108565934

BMOR:

101738709 101741781 101741955 101742796 101745818

DPL:	KGM_201906 KGM_201907 KGM_203730 KGM_205942 KGM_211104

PMAC:

106710022 106711291 106711292 106711293 106712788 106712790 106718276 106718996 106719907 106719988

PRAP:

110991285 110994263 110999668 111000881 111000882 111000883 111000886 111000893 111000894 111000902 111001155 111001160 111002340 111004489

HAW:	110369634 110371928 110372428 110372664 110374859 110376990 110376991 110381163

TNL:	113493465 113494468 113497934 113497936 113498101 113501185 113501186 113504446

PXY:	105381161 105382647 105382918 105384073 105384527 105389704

API:	100573774 103310702

DNX:

AGS:

RMD:

CLEC:

ZNE:

FCD:	110844332 110844333 110855694

DPX:	DAPPUDRAFT_231053 DAPPUDRAFT_301515 DAPPUDRAFT_303686

PVM:	113803519 113803522 113827259

ISC:	IscW_ISCW014791

TUT:

107369493

CSCU:

111618019 111618020 111618039 111618040

PTEP:

107443485 107443486 107443500 107449444 107449445 107449446

BMY:

Bm1_44405

HRO:	HELRODRAFT_70715

LGI:	LOTGIDRAFT_191692

PCAN:

112560870 112560871

CRG:	105317039 105323458 105325714 105325969 105340670

MYI:	110449544 110449545 110449546 110458931 110466215 110466238 110466244 110466251

OBI:

106869220

LAK:

106157857

SMM:	Smp_033530.1 Smp_033540 Smp_140270

SHX:	MS3_09619 MS3_09620 MS3_10972

OVI:	T265_10122 T265_13980

EGL:	EGR_04035 EGR_04036 EGR_04038 EGR_04039

NVE:	NEMVE_v1g238099

EPA:	110245171 110252725

ADF:	107331745 107355635

PDAM:

113670231 113670238 113670240

SPIS:

111327394 111327400 111327401

DGT:

HMG:

AQU:

CRB:

CSAT:

THJ:

GMX:	100787800 100811138 100814467

GSJ:	114389247 114411566 114419631

PVU:	PHAVU_003G033300g PHAVU_003G060100g

VRA:

VAR:

VUN:

CCAJ:

CAM:

AIP:

LANG:

FVE:

RCN:

PPER:

PMUM:

PAVI:

MDM:

PXB:

ZJU:

CMO:

CMAX:

CMOS:

CPEP:

RCU:

QSU:	111989944 112000575 112022063 112029133

SLY:	101244166 101250605

SPEN:

107006389 107023668

SOT:

102587809

CANN:

107865865 107875989

NTA:	107769189 107793914 107820627

NSY:	104217663 104221924 104234288

NTO:

104099524

NAU:

109228161

INI:	109163117 109165567 109189929

SIND:

105158283 105165498 105172075

OEU:

111372333

HAN:	110911119 110917661

LSV:

CCAV:

DCR:

NNU:

PSOM:

PDA:

EGU:

DCT:

AOF:

SMO:	SELMODRAFT_112669 SELMODRAFT_78232

CRE:	CHLREDRAFT_159999

CSL:	COCSUDRAFT_55771

GSL:	Gasu_14740 Gasu_24590

TTT:	THITE_2124387

VAL:	VDBG_02730

VDA:	VDAG_03647

CFJ:	CFIO01_05935

GLZ:	GLAREA_06959

PTE:

PTT_09714

BZE:	COCCADRAFT_31994

BSC:	COCSADRAFT_105489

BOR:	COCMIDRAFT_39676 COCMIDRAFT_81758

ZTR:	MYCGRDRAFT_36990

PFJ:	MYCFIDRAFT_100760 MYCFIDRAFT_41956

BCOM:

BAUCODRAFT_37592

SHS:	STEHIDRAFT_98222

ADL:	AURDEDRAFT_115777 AURDEDRAFT_115778 AURDEDRAFT_170147

GTR:	GLOTRDRAFT_136682

MRR:	Moror_6831

SCM:	SCHCODRAFT_53501

UMA:	UMAG_01815

PFP:	PFL1_02949

SRE:	PTSG_00844

ACAN:

ACA1_172860 ACA1_172870 ACA1_362920

SMIN:

v1.2.027692.t1(symbB.v1.2.027692.t1)

FCY:	FRACYDRAFT_261152

AAF:	AURANDRAFT_58590

SPAR:

SPRG_20516

GTT:	GUITHDRAFT_117185

» show all

Reference

1 [PMID:234431]

Authors

Lee SC, Levine L.

Title

Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types.

Journal

J Biol Chem 250:548-52 (1975)

Reference

2 [PMID:803247]

Authors

Lee SC, Pong SS, Katzen D, Wu KY, Levine L.

Title

Distribution of prostaglandin E 9-KETOREDUCTASE AND TYPES I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex.

Journal

Biochemistry 14:142-5 (1975)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.197

IUBMB Enzyme Nomenclature:

1.1.1.197

ExPASy - ENZYME nomenclature database:

1.1.1.197

BRENDA, the Enzyme Database:

1.1.1.197

CAS:	54989-39-8

LinkDB

DBGET integrated database retrieval system