Entry
Name
mannitol dehydrogenase;
MTD;
NAD+-dependent mannitol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
mannitol:NAD+ 1-oxidoreductase
Reaction(IUBMB)
D-mannitol + NAD+ = D-mannose + NADH + H+ [RN:
R07135 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme from Apium graveolens (celery) oxidizes alditols with a minimum requirement of 2R chirality at the carbon adjacent to the primary carbon undergoing the oxidation. The enzyme is specific for NAD+ and does not use NADP+.
History
EC 1.1.1.255 created 2000
Orthology
Genes
ECAD : 122603035 122603475
Taxonomy
Reference
Authors
Stoop JM, Pharr DM.
Title
Partial purification and characterization of mannitol: mannose 1-oxidoreductase from celeriac (Apium graveolens var. rapaceum) roots.
Journal
Reference
Authors
Stoop JM, Williamson JD, Conkling MA, Pharr DM.
Title
Purification of NAD-dependent mannitol dehydrogenase from celery suspension cultures.
Journal
Reference
Authors
Williamson JD, Stoop JM, Massel MO, Conkling MA, Pharr DM
Title
Sequence analysis of a mannitol dehydrogenase cDNA from plants reveals a function for the pathogenesis-related protein ELI3.
Journal
Sequence
Reference
4
Authors
Stoop, J.M.H., Chilton, W.S. and Pharr, D.M.
Title
Substrate specificity of the NAD-dependent mannitol dehydrogenase from celery.
Journal
Phytochemistry 43:1145-1150 (1996)
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.255
LinkDB
All DBs