Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

sulcatol:NAD+ oxidoreductase

sulcatol + NAD+ = sulcatone + NADH + H+ [RN:R05678]

R05678

sulcatol [CPD:C07288];
NAD+ [CPD:C00003]

Studies on the effects of growth-stage and nutrient supply on the stereochemistry of sulcatone reduction in Clostridia pasteurianum, C. tyrobutyricum and Lactobacillus brevis suggest that there may be at least two sulcatone reductases with different stereospecificities.

EC 1.1.1.260 created 2000, modified 2001

1

Belan, A., Botle, J., Fauve, A., Gourcy, J.G. and Veschambre, H.

Use of biological systems for the preparation of chiral molecules. 3. An application in pheromone synthesis: Preparation of sulcatol enantiomers.

J Org Chem 52:256-260 (1987)

2

Tidswell, E.C., Salter, G.J., Kell, D.B. and Morris, J.G.

Enantioselectivity of sulcatone reduction by some anaerobic bacteria.

Enzyme Microb Technol 21:143-147 (1997)

3

Tidswell, E.C., Thompson, A.N. and Morris, J.G.

Selection in chemostat culture of a mutant strain of Clostridium tryobutyricum improved in its reduction of ketones.

J Appl Microbiol Biotechnol 35:317-322 (1991)