KEGG   ENZYME: 1.1.1.291Help
Entry
EC 1.1.1.291                Enzyme                                 

Name
2-hydroxymethylglutarate dehydrogenase;
HgD
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(S)-2-hydroxymethylglutarate:NAD+ oxidoreductase
Reaction(IUBMB)
(S)-2-hydroxymethylglutarate + NAD+ = 2-formylglutarate + NADH + H+ [RN:R07985]
Reaction(KEGG)
Substrate
(S)-2-hydroxymethylglutarate;
NAD+ [CPD:C00003]
Product
2-formylglutarate [CPD:C16159];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
NADP+ cannot replace NAD+. Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC 1.17.1.5 (nicotinate dehydrogenase), EC 1.3.7.1 (6-hydroxynicotinate reductase), EC 3.5.2.18 (enamidase), EC 5.4.99.4 (2-methyleneglutarate mutase), EC 5.3.3.6 (methylitaconate Delta-isomerase), EC 4.2.1.85 (dimethylmaleate hydratase) and EC 4.1.3.32 (2,3-dimethylmalate lyase).
History
EC 1.1.1.291 created 2006
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K19647  2-hydroxymethylglutarate dehydrogenase
Genes
CPAT: CLPA_c02850(hgd)
CPAE: CPAST_c02850(hgd)
DOR: Desor_0451
TEP: TepRe1_0398
TAE: TepiRe1_0442(Hgd)
NTH: Nther_2161
IPO: Ilyop_0116
Taxonomy
Reference
1  [PMID:16894175]
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.291
IUBMB Enzyme Nomenclature: 1.1.1.291
ExPASy - ENZYME nomenclature database: 1.1.1.291
BRENDA, the Enzyme Database: 1.1.1.291
CAS: 1073478-76-8
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