| Entry |
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| Name |
2-deoxy-scyllo-inosamine dehydrogenase;
neoA (gene name);
kanK (gene name, ambiguous);
kanE (gene name, ambiguous)
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
2-deoxy-scyllo-inosamine:NAD(P)+ 1-oxidoreductase
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| Reaction(IUBMB) |
2-deoxy-scyllo-inosamine + NAD(P)+ = 3-amino-2,3-dideoxy-scyllo-inosose + NAD(P)H + H+ [RN: R08892 R10130]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Requires zinc. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, neomycin and ribostamycin. cf. EC 1.1.99.38, 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent).
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| History |
EC 1.1.1.329 created 2012
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| Pathway |
| ec00524 | Neomycin, kanamycin and gentamicin biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
| ec01130 | Biosynthesis of antibiotics |
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| Orthology |
| K13548 | 2-deoxy-scyllo-inosamine dehydrogenase |
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| Genes |
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| Reference |
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| Authors |
Kudo F, Yamamoto Y, Yokoyama K, Eguchi T, Kakinuma K. |
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| Title |
Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Nepal KK, Oh TJ, Sohng JK |
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| Title |
Heterologous production of paromamine in Streptomyces lividans TK24 using kanamycin biosynthetic genes from Streptomyces kanamyceticus ATCC12853. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.1.1.329 |
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| LinkDB |
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