KEGG   ENZYME: 1.1.1.367
Entry
EC 1.1.1.367                Enzyme                                 

Name
UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase;
WbjC;
Cap5F
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
UDP-2-acetamido-2,6-dideoxy-L-talose:NADP+ oxidoreductase
Reaction(IUBMB)
UDP-2-acetamido-2,6-dideoxy-beta-L-talose + NAD(P)+ = UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose + NAD(P)H + H+ [RN:R10665]
Reaction(KEGG)
R10665;
(other) R12552 R12553
Substrate
UDP-2-acetamido-2,6-dideoxy-beta-L-talose [CPD:C20768];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose;
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Part of the biosynthesis of UDP-N-acetyl-L-fucosamine. Isolated from the bacteria Pseudomonas aeruginosa and Staphylococcus aureus.
History
EC 1.1.1.367 created 2014
Pathway
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
Orthology
K19068  UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase
Genes
EOJ: ECO26_2944(fnlB)
ECOO: ECRM13514_2753(fnlB)
ECOH: ECRM13516_2621(fnlB)
EAB: ECABU_c23610(fnlB)
ELP: P12B_c2137(capF)
SBZ: A464_2212
SBV: N643_09265
ECAN: CWI88_07915
CUI: AFK65_12840
CTU: CTU_27300
YFR: AW19_2184
YKR: CH54_3602
ASY: AUT07_00149(fcl)
HPAS: JL26_05870
PMU: PM1008(wbjC)
PMV: PMCN06_0222(wbjC)
PMP: Pmu_01530(wbjC)
PMUL: DR93_961
PDAG: 4362423_00268(wbjC)
VTA: A2995
VFI: VF_0192(fnlB)
PNC: NCGM2_4270(wbjC)
PAEB: NCGM1900_3148(wbjC)
PPUH: B479_06960
PFS: PFLU_1658(fnl2)
PMAN: OU5_1708
PEN: PSEEN1501
PALI: A3K91_0727
ABAD: ABD1_00590
ABAU: IX87_14885
FTD: AS84_1079
FTY: CH70_511
FPH: Fphi_1263
FPT: BZ13_740
FPI: BF30_1511
FPX: KU46_48
FRC: KX01_1760(capF)
TEE: Tel_08635
APAC: S7S_10530
AVR: B565_2780
OCE: GU3_12825
PPNO: DA70_17325
PPNM: LV28_13500
CABA: SBC2_28930(wbjC)
ODI: ODI_R2816
AJS: Ajs_3029
HYB: Q5W_21530
CBAA: SRAA_0133
CBAB: SMCB_0540
EBA: ebA5887
AZA: AZKH_0898
AMYT: AMYT_0911
PACO: AACT_2069
GUR: Gura_1693
GBM: Gbem_1622(wbjC)
DEU: DBW_1517
DFL: DFE_2838
DTO: TOL2_C08120(capF)
SFU: Sfum_2863
RHT: NT26_3156
SNO: Snov_3210
HDN: Hden_0186
PAMO: BAR1_15460
SECH: B18_28745
SFLA: SPHFLASMR4Y_02428(wbjC)
BBA: Bd1694(capF)
BNC: BCN_5195
PSYO: PB01_03865
SAU: SA0149(capF)
SAV: SAV0154(capF)
SAW: SAHV_0153(capF)
SAM: MW0129(cap8F)
SAS: SAS0129
SAR: SAR0156(capF)
SAC: SACOL0141(cap5F)
SAX: USA300HOU_0168(cap5F)
SAA: SAUSA300_0157(cap5F)
SAE: NWMN_0100(capF)
SAD: SAAV_0122(cap5F)
SUE: SAOV_0101
SUJ: SAA6159_00138(cap5F)
SUK: SAA6008_00132(cap5F)
SUC: ECTR2_111
SUZ: MS7_0148(capF)
SUX: SAEMRSA15_01200(capF)
SUW: SATW20_01650(capF)
SUG: SAPIG0168
SUF: SARLGA251_01280(capF)
SAUA: SAAG_00637
SAUE: RSAU_000108(capF)
SAUS: SA40_0121(capF)
SAUU: SA957_0136(capF)
SAUG: SA268_0133(capF)
SAUT: SAI1T1_2001090(cap5F)
SAUJ: SAI2T2_1001090(cap5F)
SAUK: SAI3T3_1001090(cap5F)
SAUQ: SAI4T8_1001090(cap5F)
SAUF: X998_0137
SAB: SAB0095(capF)
SUY: SA2981_0155(capF)
SAUB: C248_0143(capF)
SAUM: BN843_1600
SAUC: CA347_165
SAUR: SABB_01687(capF)
SAUI: AZ30_00810
SAUD: CH52_04955
SAMS: NI36_00705
SHA: SH0393(capF)
SHH: ShL2_00298(cap5F)
SLN: SLUG_03250(capF)
SAGQ: EP23_07990
SARL: SAP2_22730
LLR: llh_0475
SPN: SP_0359(cps4K)
MPX: MPD5_1385
CARC: NY10_927
RCH: RUM_09630
FPR: FP2_31570
BPB: bpr_I0350
BHU: bhn_I0406
CPY: Cphy_3503
HSD: SD1D_1290
SLP: Slip_0164
DRM: Dred_3032
ELM: ELI_4558
CBAR: PATL70BA_0362(wbjC)
PUF: UFO1_4150
ERH: ERH_0859
EUC: EC1_12020
ACL: ACL_1044
RSA: RSal33209_1612(capF)
CFL: Cfla_0760
NDK: I601_1757
DFC: DFI_17510
RUL: UC8_50260
LIL: LA_1644
LIE: LIF_A1330
LIC: LIC_12140
LIS: LIL_12274(wcaG3)
FSC: FSU_3261
BTH: BT_0382
BFR: BF1107
PDI: BDI_3832
PRU: PRU_0102
DORI: FH5T_21510
CPI: Cpin_4751
FPS: FP1286(fnlB)
FBR: FBFL15_1033(fnlB)
FIN: KQS_03315(fnlB)
COC: Coch_1111
CBAT: M666_12275
DDO: I597_2182
MLT: VC82_2498
NDO: DDD_3541(fnlB)
MESQ: C7H62_1057
PPH: Ppha_0559
THER: Y592_04250
CABY: Cabys_3398
 » show all
Reference
1  [PMID:12464616]
  Authors
Kneidinger B, O'Riordan K, Li J, Brisson JR, Lee JC, Lam JS
  Title
Three highly conserved proteins catalyze the conversion of UDP-N-acetyl-D-glucosamine to precursors for the biosynthesis of O antigen in Pseudomonas aeruginosa O11 and capsule in Staphylococcus aureus type 5. Implications for the UDP-N-acetyl-L-fucosamine biosynthetic pathway.
  Journal
J Biol Chem 278:3615-27 (2003)
DOI:10.1074/jbc.M203867200
  Sequence
Reference
2  [PMID:15778500]
  Authors
Mulrooney EF, Poon KK, McNally DJ, Brisson JR, Lam JS
  Title
Biosynthesis of UDP-N-acetyl-L-fucosamine, a precursor to the biosynthesis of lipopolysaccharide in Pseudomonas aeruginosa serotype O11.
  Journal
J Biol Chem 280:19535-42 (2005)
DOI:10.1074/jbc.M500612200
Reference
3  [PMID:18540063]
  Authors
Miyafusa T, Tanaka Y, Kuroda M, Ohta T, Tsumoto K
  Title
Expression, purification, crystallization and preliminary diffraction analysis of CapF, a capsular polysaccharide-synthesis enzyme from Staphylococcus aureus.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 64:512-5 (2008)
DOI:10.1107/S174430910801213X
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.367
IUBMB Enzyme Nomenclature: 1.1.1.367
ExPASy - ENZYME nomenclature database: 1.1.1.367
BRENDA, the Enzyme Database: 1.1.1.367
LinkDB

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