KEGG   ENZYME: 1.1.1.401Help
Entry
EC 1.1.1.401                Enzyme                                 

Name
2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD+);
2-keto-3-deoxy-L-rhamnonate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-dehydro-3-deoxy-L-rhamnonate:NAD+ 4-oxidoreductase
Reaction(IUBMB)
2-dehydro-3-deoxy-L-rhamnonate + NAD+ = 2,4-didehydro-3-deoxy-L-rhamnonate + NADH + H+ [RN:R11339]
Reaction(KEGG)
Substrate
2-dehydro-3-deoxy-L-rhamnonate [CPD:C03979];
NAD+ [CPD:C00003]
Product
2,4-didehydro-3-deoxy-L-rhamnonate [CPD:C20781];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacteria Sphingomonas sp. SKA58 and Sulfobacillus thermosulfidooxidans, is involved in the non-phosphorylative degradation pathway for L-rhamnose. It does not show any detectable activity with NADP+ or with other aldoses.
History
EC 1.1.1.401 created 2016
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K21883  2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD+)
Genes
PPF: Pput_2199
PPG: PputGB1_2345
PPW: PputW619_2844
PPI: YSA_00165
PPX: T1E_2289
PPUT: L483_18725
PPUN: PP4_22550
GAI: IMCC3135_16660(fabG_4)
MME: Marme_1649
REH: H16_B1075(h16_B1075)
CNC: CNE_2c10320(fabG7) CNE_BB1p11630(fabG16)
CGD: CR3_3352(fabG)
BFN: OI25_6822
PPUL: RO07_13835
VEI: Veis_0638
RTA: Rta_09040
LIM: L103DPR2_00634(fabG_5)
LIH: L63ED372_02617(fabG_7)
HSE: Hsero_0584(fabG) Hsero_1263(fabG)
HRB: Hrubri_1079(fabG)
MES: Meso_0411
ATU: Atu3813(fabG) Atu4595
RLE: RL2674
RLG: Rleg_2210
NEN: NCHU2750_48930(fabG)
BJA: bll3655 bll3913(fabG) bll6359
BRA: BRADO3101
BBT: BBta_3549
BRS: S23_43210(fabG)
AOL: S58_45070
BRAD: BF49_1142
BRO: BRAD285_2845(fabG)
RPA: RPA3474(fabG4)
RPB: RPB_2093
RPC: RPC_3650
RPD: RPD_3326
RPE: RPE_3690
RPT: Rpal_3964
VGO: GJW-30_1_00198(fabG_1)
XAU: Xaut_1907
AZC: AZC_2269
SNO: Snov_4089
MET: M446_4913
MAQU: Maq22A_c13140(fabG)
MMED: Mame_04374(actIII_3)
HDI: HDIA_4541(fabG_25)
RBM: TEF_05635
SIL: SPO2413
RSP: RSP_3888(fabG)
RDE: RD1_3872
KRO: BVG79_p1000086(fabG)
SPSE: SULPSESMR1_01364(fabG)
HBA: Hbal_2758
SPHI: TS85_02210
SSAN: NX02_22765
SPHR: BSY17_3164
BLAS: BSY18_1711
ACR: Acry_2467
SHUM: STHU_24740(fabG_3)
PSAB: PSAB_03640
CGT: cgR_2332
RER: RER_46900
REY: O5Y_22145
ROP: ROP_15410
NAL: B005_2522
GOB: Gobs_2441
GES: VT84_10250(fabG_6)
SACI: Sinac_5872
PBOR: BSF38_05220(tsaC1)
ABAS: ACPOL_0913
PHE: Phep_2313
DFE: Dfer_3040
SLI: Slin_0608
 » show all
Taxonomy
Reference
1  [PMID:19187228]
  Authors
Watanabe S, Makino K
  Title
Novel modified version of nonphosphorylated sugar metabolism--an alternative L-rhamnose pathway of Sphingomonas sp.
  Journal
FEBS J 276:1554-67 (2009)
DOI:10.1111/j.1742-4658.2009.06885.x
  Sequence
Reference
2  [PMID:25617114]
  Authors
Bae J, Kim SM, Lee SB
  Title
Identification and characterization of 2-keto-3-deoxy-L-rhamnonate dehydrogenase  belonging to the MDR superfamily from the thermoacidophilic bacterium Sulfobacillus thermosulfidooxidans: implications to L-rhamnose metabolism in archaea.
  Journal
Extremophiles 19:469-78 (2015)
DOI:10.1007/s00792-015-0731-8
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.401
IUBMB Enzyme Nomenclature: 1.1.1.401
ExPASy - ENZYME nomenclature database: 1.1.1.401
BRENDA, the Enzyme Database: 1.1.1.401
LinkDB All DBs

DBGET integrated database retrieval system