KEGG   ENZYME: 1.1.1.420
Entry
EC 1.1.1.420                Enzyme                                 

Name
D-apiose dehydrogenase;
apsD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-apiofuranose:NAD+ 1-oxidoreductase
Reaction(IUBMB)
D-apiofuranose + NAD+ = D-apionolactone + NADH + H+ [RN:R12502]
Reaction(KEGG)
R12502
Substrate
D-apiofuranose [CPD:C21040];
NAD+ [CPD:C00003]
Product
D-apionolactone [CPD:C22218];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from several bacterial species, is involved in a catabolic pathway for D-apiose.
History
EC 1.1.1.420 created 2019
Orthology
K23244  D-apiose dehydrogenase
Genes
YEL: LC20_03977
YAK: ACZ76_03285
YMA: DA391_06270
YHI: D5F51_15710
COLW: A3Q33_17725
CATE: C2869_05170
GAI: IMCC3135_02045(yhhX_1) IMCC3135_20395(yhhX_2) IMCC3135_21765(yhhX_3)
HAA: A5892_08245
KMA: B9H00_09335
BCAI: K788_0005386
AMIM: MIM_c01400
POL: Bpro_3819
MLO: mll7010
MHUA: MCHK_0234
SME: SM_b20353
SMER: DU99_31530
SMD: Smed_3766
ARA: Arad_9238
SHZ: shn_27380
OAN: Oant_3060
OAH: DR92_3443
MET: M446_1313
MMED: Mame_04748(afr_4)
RBM: TEF_16860
RUT: FIU92_00100(afr1)
JAN: Jann_3062
RDE: RD1_3788
DSH: Dshi_3394
MALG: MALG_04066
LABT: FIU93_26710(ydgJ) FIU93_28805(afr4)
MALU: KU6B_32170
ACR: Acry_1061
SHUM: STHU_22600
PPY: PPE_03804
PRI: PRIO_3529
PSWU: SY83_22150
TRO: trd_0133
TTR: Tter_1997
RBA: RB3770
MFF: MFFC18_42680(idhA)
SACI: Sinac_4983
AGV: OJF2_37170(ycjS_3)
ABAS: ACPOL_4621
FSN: GS03_01704(iolG_1)
 » show all
Reference
1  [PMID:29867142]
  Authors
Carter MS, Zhang X, Huang H, Bouvier JT, Francisco BS, Vetting MW, Al-Obaidi N, Bonanno JB, Ghosh A, Zallot RG, Andersen HM, Almo SC, Gerlt JA
  Title
Functional assignment of multiple catabolic pathways for D-apiose.
  Journal
Nat Chem Biol 14:696-705 (2018)
DOI:10.1038/s41589-018-0067-7
  Sequence
[ara:Arad_9238]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.420
IUBMB Enzyme Nomenclature: 1.1.1.420
ExPASy - ENZYME nomenclature database: 1.1.1.420
BRENDA, the Enzyme Database: 1.1.1.420
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