KEGG ENZYME: 1.14.13.219

ENZYME: 1.14.13.219

Entry

EC 1.14.13.219              Enzyme

Name

resorcinol 4-hydroxylase (NADPH)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

resorcinol,NADPH:oxygen oxidoreductase (4-hydroxylating)

Reaction(IUBMB)

resorcinol + NADPH + H+ + O2 = hydroxyquinol + NADP+ + H2O [RN:R05249]

Reaction(KEGG)

R05249

Substrate

resorcinol [CPD:C01751];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]

Product

hydroxyquinol [CPD:C02814];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Comment

The enzyme, characterized from the bacterium Corynebacterium glutamicum, is a single-component hydroxylase. The enzyme has no activity with NADH. cf. EC 1.14.13.220, resorcinol 4-hydroxylase (NADH), and EC 1.14.14.27, resorcinol 4-hydroxylase (FADH2).

History

EC 1.14.13.219 created 2016

Pathway

ec00362

Benzoate degradation

ec01120

Microbial metabolism in diverse environments

Orthology

K20943

resorcinol 4-hydroxylase (NADPH)

Genes

PHEF:

PSH57_10905 PSH57_11115

PTRO:

G5S35_15145

NARM:

N7E01_02740

RHIA:

ACO34A_19190

XDI:	EZH22_02295 EZH22_05830

CBAK:

DA792_08330

PPAN:

ESD82_09910

PFEO:

E3U26_16755

TLB:	RPE78_15120

CGL:	Cgl1158(Cgl1158)

CGB:

cg1309

CGU:	WA5_1111(MhpA)

CGT:

cgR_1240

CGS:	C624_06615(mhpA)

CGG:	C629_06615(mhpA)

CGM:

cgp_1309

CSUR:

N24_1278(mhpA)

ROP:

ROP_42950

RPSK:

JWS13_43960

RHOU:

KZJ41_13865

PSOW:

ABI214_07975

» show all

Reference

1 [PMID:16963551]

Authors

Huang Y, Zhao KX, Shen XH, Chaudhry MT, Jiang CY, Liu SJ

Title

Genetic characterization of the resorcinol catabolic pathway in Corynebacterium glutamicum.

Journal

Appl Environ Microbiol 72:7238-45 (2006)
DOI:10.1128/AEM.01494-06

Sequence

[cgl:Cgl1158]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.13.219

IUBMB Enzyme Nomenclature:

1.14.13.219

ExPASy - ENZYME nomenclature database:

1.14.13.219

BRENDA, the Enzyme Database:

1.14.13.219

LinkDB

DBGET integrated database retrieval system