Entry
Name
fumitremorgin C monooxygenase;
ftmG (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
fumitremorgin C,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12alpha,13alpha-dihydroxyfumitremorgin C-forming)
Reaction(IUBMB)
fumitremorgin C + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH---hemoprotein reductase] + 2 H2O [RN:
R10414 ]
Reaction(KEGG)
Substrate
fumitremorgin C [CPD:
C20604 ];
[reduced NADPH---hemoprotein reductase] [CPD:
C03024 ];
O2 [CPD:
C00007 ]
Product
12alpha,13alpha-dihydroxyfumitremorgin C [CPD:
C20605 ];
[oxidized NADPH---hemoprotein reductase] [CPD:
C03161 ];
H2O [CPD:
C00001 ]
Comment
A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathway of the indole alkaloid verruculogen.
History
EC 1.14.14.119 created 2013 as EC 1.14.13.177, transferred 2018 to EC 1.14.14.119
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K17826 fumitremorgin C monooxygenase
Genes
Taxonomy
Reference
Authors
Kato N, Suzuki H, Takagi H, Asami Y, Kakeya H, Uramoto M, Usui T, Takahashi S, Sugimoto Y, Osada H
Title
Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.
Journal
Sequence
Other DBs
LinkDB
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