KEGG   ENZYME: 1.17.3.5
Entry
EC 1.17.3.5                 Enzyme                                 
Name
4-oxocyclohexanecarboxylate 2-dehydrogenase;
chcC1 (gene name);
4-oxocyclohexanecarboxylate desaturase I;
4-oxocyclohexanecarboxylate 2-desaturase
Class
Oxidoreductases;
Acting on CH or CH2 groups;
With oxygen as acceptor
Sysname
4-oxocyclohexane-1-carboxylate:oxygen oxidoreductase (4-oxocyclohex-2-ene-1-carboxylate-forming)
Reaction(IUBMB)
4-oxocyclohexane-1-carboxylate + O2 = 4-oxocyclohex-2-ene-1-carboxylate + H2O2 [RN:R13285]
Reaction(KEGG)
R13285
Substrate
4-oxocyclohexane-1-carboxylate [CPD:C03767];
O2 [CPD:C00007]
Product
4-oxocyclohex-2-ene-1-carboxylate [CPD:C22887];
H2O2 [CPD:C00027]
Comment
Contains FAD. The enzyme, characterized from the bacterium Corynebacterium cyclohexanicum, participates in a cyclohexane-1-carboxylate degradation pathway.
History
EC 1.17.3.5 created 2024
Orthology
K27500  4-oxocyclohexanecarboxylate 2-dehydrogenase
Genes
CGT: cgR_0064
CCJZ: ccrud_00210
CSUR: N24_0047(kstD)
CCYC: SCMU_09940(chcC1)
CFAC: CFAEC_12715(kstD1)
CGF: CGUA_00475(kstD)
SUBT: KPL76_01985
ART: Arth_2287
ARY: ATC04_00425
ARQ: BWQ92_20415
ARTP: E5206_02050
ACAO: NF551_15335
AOD: Q8Z05_19565
PNV: JMY29_09675
PDEL: JCQ34_08330
GPR: JQN66_00255
SATK: SA2016_1183
 » show all
Reference
1  [PMID:8281951]
  Authors
Kaneda T, Obata H, Tokumoto M.
  Title
Aromatization of 4-oxocyclohexanecarboxylic acid to 4-hydroxybenzoic acid by two distinctive desaturases from Corynebacterium cyclohexanicum. Properties of two desaturases.
  Journal
Eur J Biochem 218:997-1003 (1993)
DOI:10.1111/j.1432-1033.1993.tb18458.x
Reference
2  [PMID:34583900]
  Authors
Yamamoto T, Hasegawa Y, Lau PCK, Iwaki H
  Title
Identification and characterization of a chc gene cluster responsible for the aromatization pathway of cyclohexanecarboxylate degradation in Sinomonas cyclohexanicum ATCC 51369.
  Journal
J Biosci Bioeng 132:621-629 (2021)
DOI:10.1016/j.jbiosc.2021.08.013
  Sequence
[ccyc:SCMU_09940]
Other DBs
ExplorEnz - The Enzyme Database: 1.17.3.5
IUBMB Enzyme Nomenclature: 1.17.3.5
ExPASy - ENZYME nomenclature database: 1.17.3.5
BRENDA, the Enzyme Database: 1.17.3.5
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