| Entry |
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| Name |
[histone H3]-lysine9 N-trimethyltransferase;
KMT1A (gene name);
KMT1B (gene name);
KMT1C (gene name);
KMT1D (gene name);
KMT1E (gene name);
KMT1F (gene name);
MT8 (gene name);
SUV39H1 (gene name);
G9A (gene name);
EHMT1 (gene name);
PRDM2 (gene name)
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:[histone H3]-L-lysine9 N6-methyltransferase
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| Reaction(IUBMB) |
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9;
(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
[histone H3]-L-lysine9;
[histone H3]-N6-methyl-L-lysine9;
[histone H3]-N6,N6-dimethyl-L-lysine9
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine9;
[histone H3]-N6-methyl-L-lysine9;
[histone H3]-N6,N6-dimethyl-L-lysine9
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| Comment |
This entry describes several enzymes that successively methylate the L-lysine9 residue of histone H3 (H3K9), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes.
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| History |
EC 2.1.1.355 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.355
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| Pathway |
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| Orthology |
| K11419 | [histone H3]-lysine9 N-trimethyltransferase SUV39H |
| K11420 | [histone H3]-lysine9 N-trimethyltransferase EHMT |
| K11421 | [histone H3]-lysine9 N-trimethyltransferase SETDB1 |
| K11432 | [histone H3]-lysine9 N-trimethyltransferase PRDM2 |
| K18494 | [histone H3]-lysine9 N-trimethyltransferase SETDB2 |
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| Genes |
» show all
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| Reference |
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| Authors |
O'Carroll D, Scherthan H, Peters AH, Opravil S, Haynes AR, Laible G, Rea S, Schmid M, Lebersorger A, Jerratsch M, Sattler L, Mattei MG, Denny P, Brown SD, Schweizer D, Jenuwein T |
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| Title |
Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. |
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| Journal |
Mol Cell Biol 20:9423-33 (2000) |
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| Sequence |
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| Reference |
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| Authors |
Schotta G, Ebert A, Krauss V, Fischer A, Hoffmann J, Rea S, Jenuwein T, Dorn R, Reuter G |
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| Title |
Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. |
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| Journal |
EMBO J 21:1121-31 (2002) |
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| Sequence |
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| Reference |
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| Authors |
Tachibana M, Sugimoto K, Nozaki M, Ueda J, Ohta T, Ohki M, Fukuda M, Takeda N, Niida H, Kato H, Shinkai Y |
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| Title |
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. |
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| Journal |
Genes Dev 16:1779-91 (2002) |
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| Sequence |
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| Reference |
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| Authors |
Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ 3rd |
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| Title |
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. |
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| Journal |
Genes Dev 16:919-32 (2002) |
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| Sequence |
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| Reference |
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| Authors |
Kim KC, Geng L, Huang S |
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| Title |
Inactivation of a histone methyltransferase by mutations in human cancers. |
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| Journal |
Cancer Res 63:7619-23 (2003) |
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| Sequence |
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| Reference |
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| Authors |
Wu H, Min J, Lunin VV, Antoshenko T, Dombrovski L, Zeng H, Allali-Hassani A, Campagna-Slater V, Vedadi M, Arrowsmith CH, Plotnikov AN, Schapira M |
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| Title |
Structural biology of human H3K9 methyltransferases. |
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| Journal |
PLoS One 5:e8570 (2010) |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.355 |
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| LinkDB |
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