KEGG   ENZYME: 2.1.3.7
Entry
EC 2.1.3.7                  Enzyme                                 

Name
3-hydroxymethylcephem carbamoyltransferase
Class
Transferases;
Transferring one-carbon groups;
Carboxy- and carbamoyltransferases
Sysname
carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase
Reaction(IUBMB)
carbamoyl phosphate + a 3-hydroxymethylceph-3-em-4-carboxylate = phosphate + a 3-carbamoyloxymethylcephem [RN:R04281]
Reaction(KEGG)
R04281 > R05230
Substrate
carbamoyl phosphate [CPD:C00169];
3-hydroxymethylceph-3-em-4-carboxylate
Product
phosphate [CPD:C00009];
3-carbamoyloxymethylcephem [CPD:C03674]
Comment
Acts on a wide range of 3-hydroxymethylcephems (a subclass of the cephalosporin antibiotics). Activated by ATP.
History
EC 2.1.3.7 created 1983
Pathway
ec00311  Penicillin and cephalosporin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K04128  hydroxymethyl cephem carbamoyltransferase
Genes
RSL: RPSI07_2714
RSN: RSPO_c02723(cmcH)
SCT: SCAT_5682(cmcH)
SCY: SCATT_56820
SCLF: BB341_05070 BB341_07765
AAB: A4R43_03245
AMYY: YIM_39160(novN2)
Reference
1  [PMID:6248024]
  Authors
Brewer SJ, Taylor PM, Turner MK.
  Title
An adenosine triphosphate-dependent carbamoylphosphate--3-hydroxymethylcephem O-carbamoyltransferase from Streptomyces clavuligerus.
  Journal
Biochem J 185:555-64 (1980)
DOI:10.1042/bj1850555
Other DBs
ExplorEnz - The Enzyme Database: 2.1.3.7
IUBMB Enzyme Nomenclature: 2.1.3.7
ExPASy - ENZYME nomenclature database: 2.1.3.7
BRENDA, the Enzyme Database: 2.1.3.7
CAS: 74315-96-1
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