Entry
Name
GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase;
ALG11;
ALG11 mannosyltransferase;
LEW3 (gene name);
At2G40190 (gene name);
gmd3 (gene name);
galactomannan deficiency protein 3;
GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase;
glycolipid 2-alpha-mannosyltransferase;
GDP-mannose:glycolipid 2-alpha-D-mannosyltransferase;
GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase;
GDP-alpha-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 2-alpha-D-mannosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-alpha-D-mannose:alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol 2-alpha-D-mannosyltransferase (configuration-retaining)
Reaction(IUBMB)
2 GDP-alpha-D-mannose + alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = 2 GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol [RN:
R06127 R06128 ]
Reaction(KEGG)
Substrate
GDP-alpha-D-mannose [CPD:
C00096 ];
alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
Product
GDP [CPD:
C00035 ];
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
Comment
The biosynthesis of asparagine-linked glycoproteins (N-linked protein glycosylation) utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway. ALG11 mannosyltransferase from Saccharomyces cerevisiae carries out two sequential steps in the formation of the lipid-linked core oligosaccharide, adding two mannose residues in alpha(1->2) linkages to the nascent oligosaccharide.
History
EC 2.4.1.131 created 1984, modified 2011, modified 2012
Pathway
ec00513 Various types of N-glycan biosynthesis
Orthology
K03844 alpha-1,2-mannosyltransferase
Genes
CJC : 100387786 118153096(ALG11)
CGE : 100765573 100771009(Alg11)
BTAX : 128057748(ALG11) 128067546
XLA : 108709929(alg11.S) 733388(alg11.L)
SRX : 107707840(alg11) 107719740
SANH : 107654269 107705036
MASI : 127443703 127444930
CGOB : 115005546 115016818
ELY : 117249389 117249821(alg11)
EFO : 125884921(alg11) 125899599
PLEP : 121949579 121962802(alg11)
SLUC : 116044786(alg11) 116046590
GAT : 120821231(alg11) 120834188
PPUG : 119218192(alg11) 119229047
AFB : 129104676 129111845(alg11)
CLUM : 117743694(alg11) 117750324
PSWI : 130201356 130204353(alg11)
CANA : 137782767 137794052(alg11)
CVE : 137866188 137879169(alg11)
MSAM : 119902765(alg11) 119903795 119903810
SCHU : 122872172(alg11) 122885140
SPUL : 138592541 138603608(alg11)
LMIX : 132959785(alg11) 132987168
ALAT : 119015052(alg11) 119026024
OAU : 116319181(alg11) 116325677
CSAI : 133424917(alg11) 133445820
PRET : 103460209 103475530(alg11)
PFOR : 103147127 103156459
PLAI : 106950965(alg11) 106959338
PMEI : 106905185 106927247
GAF : 122827451(alg11) 122840391
PPRL : 129379097 129379303
CVG : 107090117 107093727(alg11)
CTUL : 119779536(alg11) 119790196
GMU : 124861745(alg11) 124871209
KMR : 108246705(alg11) 108248628
ALIM : 106527755 106529639
NWH : 119419334 119428684(alg11)
AOCE : 111570845 111580790(alg11)
EJA : 138201557 138208424(alg11)
BFRE : 138620819(alg11) 138633722
MCEP : 125000607(alg11) 125017789
HHIP : 117754444 117777436(alg11)
HSP : 118103142(alg11) 118120451
PPLT : 128430825(alg11) 128455562
SMAU : 118282821 118301363(alg11)
SLAL : 111644468 111659517
XGL : 120797907(alg11) 120801467
PEE : 133410764(alg11) 133411016
PTAO : 133487290 133489826(alg11)
MALB : 109955804(alg11) 109972602
BSPL : 114846718 114870176(alg11)
SJO : 128354142(alg11) 128367496
SSCO : 133976281(alg11) 133993436
SASA : 100380802(alg11) 106586488
STRU : 115161027 115195938
OTW : 112239598 112253922(alg11)
OMY : 110495950(alg11) 110520341
SALP : 111953314 111953546 111977861
CCLU : 121536956 121554178 121571753
PSPA : 121320558 121327568
ARUT : 117405435 117406822 117407227
DSI : Dsimw501_GD14979(Dsim_GD14979)
DYA : Dyak_GE19778 Dyak_GE23039
CLON : 129605933 129618189
BCOO : 119066820 119072984
VVE : 124950697 124950698 124950699
TPRE : 106648864 106649651 106654879
AGIF : 122858573 122860803
PPYR : 116167150 116169322
CFEL : 113374752 113376557
AFRA : 136040734 136041298
PPOI : 119092205 119107650
ABRU : 129959228 129965477
CEL : CELE_B0361.8(algn-11)
BMY : BM_BM1776(Bma-algn-11)
AIRR : 138312728 138327614
SHX : MS3_00005377(ALG11_1)
MCAZ : 138016285 138017070
CSAT : 104782492 104785390 104792874
MINC : 123193516 123226977
HSYR : 120128724 120162302
AHF : 112710644 112716810 112775743
MSYL : 126630415 126633710
PXB : 103936944 103958626 103967036
SDUL : 129877527 129892162
CANN : 107846010 107862527
SSPL : 121761885 121775348 121777659 121796733
SHIS : 125206788 125219000
APAN : 127256717 127259777
AEW : 130764138 130770175 130774757
PSOM : 113275484 113280281 113282131 113283906 113314456
TAES : 123102409 123110585 123119608
MFLO : 136504768 136508558
PVIR : 120666705 120699929
MUS : 135614302 135614676 135614678
SMO : SELMODRAFT_80274(GT4A6)
CGR : 2887168(GVI51_D01001)
NCS : NCAS_0G03240(NCAS0G03240)
NDI : NDAI_0D01260(NDAI0D01260)
TPF : TPHA_0D01640(TPHA0D01640)
TBL : TBLA_0B05860(TBLA0B05860)
TDL : TDEL_0C03950(TDEL0C03950)
KAF : KAFR_0H03470(KAFR0H03470)
KNG : KNAG_0H02170(KNAG0H02170)
LBG : 92209351(LODBEIA_P41550)
CAL : CAALFM_C602270CA(ALG11)
ASAU : 88173279(PUMCH_002214)
YLI : 2910710(YALI2_D00942g)
NTE : NEUTE1DRAFT123179(NEUTE1DRAFT_123179)
SMP : 10802317(SMAC4_06770)
PBEL : QC761_309230(ALG11)
PPSD : QC762_309230(ALG11)
PPSP : QC763_309230(ALG11)
PPSA : QC764_309230(ALG11)
FPOA : FPOAC1_009588(ALG11)
TATV : 25784236(TrAtP1_003740)
PLJ : 28888846(PLICBS_009268)
PTKZ : JDV02_005962(ALG11)
CDET : 87943143(CDEST_06640)
ALUC : AKAW2_31041A(ALG11)
PTRR : 6342539(PtrM4_089430)
ADAC : 96084326(ACET3X_004004)
ZTR : MYCGRDRAFT_111451(ALG)
CDEP : 91088937(L203_104727)
KMG : 30161840(I203_107280)
KNE : 92182475(IAR55_005217)
CCAC : CcaHIS019_0607760(ALG11)
DSQ : DICSQDRAFT_158064 DICSQDRAFT_94093
PCO : PHACADRAFT_154412 PHACADRAFT_214476
LBC : LACBIDRAFT_399402(ALG11)
ABP : AGABI1DRAFT123007(AGABI1DRAFT_123007)
ABV : AGABI2DRAFT202169(AGABI2DRAFT_202169)
MORE : E1B28_012192 E1B28_012813
SCM : SCHCO_02697704(SCHCODRAFT_02697704)
PSTR : Pst134EA_000529 Pst134EA_032401
EHI : EHI_093950(3.t00023)
FCY : FRACYDRAFT_183873(GT2)
LMAT : 92511420(LSCM1_01286)
LOI : 92357711(LSCM4_01730)
LEIS : 94176934(GH5_01329)
LENR : 94168594(CUR178_01311)
LEIN : 94185074(JIQ42_01331)
PHET : 94287646(JKF63_01522)
EHX : EMIHUDRAFT_228113 EMIHUDRAFT_229831
» show all
Taxonomy
Reference
Authors
O'Reilly MK, Zhang G, Imperiali B.
Title
In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis.
Journal
Sequence
Reference
Authors
Absmanner B, Schmeiser V, Kampf M, Lehle L
Title
Biochemical characterization, membrane association and identification of amino acids essential for the function of Alg11 from Saccharomyces cerevisiae, an alpha1,2-mannosyltransferase catalysing two sequential glycosylation steps in the formation of the lipid-linked core oligosaccharide.
Journal
Sequence
Reference
Authors
Schutzbach JS, Springfield JD, Jensen JW.
Title
The biosynthesis of oligosaccharide-lipids. Formation of an alpha-1,2-mannosyl-mannose linkage.
Journal
J Biol Chem 255:4170-5 (1980)
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.131
LinkDB
All DBs