| Entry |
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| Name |
cystathionine beta-synthase (O-acetyl-L-serine);
MccB;
O-acetylserine dependent cystathionine beta-synthase
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
O-acetyl-L-serine:L-homocysteine 2-amino-2-carboxyethyltransferase
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| Reaction(IUBMB) |
O-acetyl-L-serine + L-homocysteine = L-cystathionine + acetate [RN: R10305]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A pyridoxal 5'-phosphate protein. The enzyme, purified from the bacterium Bacillus subtilis, also has a low activity with L-serine (cf. EC 4.2.1.22, cystathionine beta-synthase).
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| History |
EC 2.5.1.134 created 2016
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| Pathway |
| ec00270 | Cysteine and methionine metabolism |
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| Orthology |
| K17216 | cystathionine beta-synthase (O-acetyl-L-serine) |
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| Genes |
» show all
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| Reference |
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| Authors |
Hullo MF, Auger S, Soutourina O, Barzu O, Yvon M, Danchin A, Martin-Verstraete I |
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| Title |
Conversion of methionine to cysteine in Bacillus subtilis and its regulation. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.5.1.134 |
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| LinkDB |
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