KEGG   ENZYME: 2.6.1.98Help
Entry
EC 2.6.1.98                 Enzyme                                 

Name
UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase;
WbpE;
WlbC
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate:2-oxoglutarate aminotransferase
Reaction(IUBMB)
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate + 2-oxoglutarate = UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + L-glutamate [RN:R10141]
Reaction(KEGG)
Substrate
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate [CPD:C20359];
2-oxoglutarate [CPD:C00026]
Product
UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate [CPD:C20395];
L-glutamate [CPD:C00025]
Comment
A pyridoxal 5'-phosphate protein. This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide. The enzymes from Pseudomonas aeruginosa serotype O5 and Thermus thermophilus form a complex with the previous enzyme in the pathway, EC 1.1.1.335 (UDP-N-acetyl-2-amino-2-deoxyglucuronate oxidase).
History
EC 2.6.1.98 created 2012
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K13017  UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase
Genes
PLU: plu4799(wblD)
PLUM: A4R40_23870
PAY: PAU_04314(wblD)
PTT: VY86_07530
XBO: XBJ1_4316
XNE: XNC1_0114
XNM: XNC2_0116
MSU: MS1498(wecE)
ASU: Asuc_0108
AAZ: ADJ80_05785
PAE: PA3155(wbpE)
PAEV: N297_3266(wbpE)
PAEI: N296_3266(wbpE)
PAEM: U769_09137
PAEC: M802_3264(wbpE)
PAEO: M801_3131(wbpE)
PMY: Pmen_1860
PPUH: B479_06915
PSES: PSCI_2868
PSOS: POS17_4989
PSET: THL1_1979
ACB: A1S_0055
ACC: BDGL_002974(degT)
MARJ: MARI_04660(wbpE)
AAUS: EP12_05255
SDE: Sde_0869
CBU: CBU_0825
CBD: CBUD_0890
CBG: CbuG_1176
CBC: CbuK_0693
LPN: lpg1424
LPH: LPV_1541
LPO: LPO_1421
LPM: LP6_1405(dnrJ)
LPF: lpl1375
LPP: lpp1379
LPC: LPC_0840
LPA: lpa_02088
LPE: lp12_1362
LLO: LLO_1795
LFA: LFA_1370(wbpE)
LHA: LHA_1875(degT)
LOK: Loa_02109
LCD: clem_05795(wbpE)
LLG: 44548918_01052(arnB_1)
LJR: NCTC11533_01253(arnB_1)
TMC: LMI_1805(degT)
TIG: THII_3198
TNI: TVNIR_0691(degT_[H])
HCO: LOKO_02147(wbpE)
ADI: B5T_01710
SALN: SALB1_3707
ENM: EBS_1934
CVI: CV_4124
LHK: LHK_02803
PSE: NH8B_0416
AMAH: DLM_4449
REH: H16_B0031(wbpE)
PPNO: DA70_17280
LMIR: NCTC12852_00302(arnB_1)
BPE: BP0091(bplC)
BPC: BPTD_0087(bplC)
BPER: BN118_0160(wlbC)
BPET: B1917_0094(bplC)
BPEU: Q425_2040(bplC)
BPAR: BN117_0151(wlbC)
BPA: BPP0153(bplC)
BBH: BN112_3258(wlbC)
BBR: BB0153(bplC)
BBM: BN115_0142(wlbC)
BBX: BBS798_0152(bplC)
BPT: Bpet4818(wlbC)
BAV: BAV0096(wlbC)
BHO: D560_1330(wbpE)
BHM: D558_1319(wbpE)
BHZ: ACR54_00108(wbpE)
BTRM: SAMEA390648701340(wlbC)
AXX: ERS451415_06025(arnB_1)
TEA: KUI_0410
TEG: KUK_0144
ODI: ODI_R2824
PNA: Pnap_3126
AAV: Aave_0952
AJS: Ajs_3018
CTES: O987_08020
HYB: Q5W_21485
MMS: mma_2280(wecE2)
HSE: Hsero_4197(wecE)
LCH: Lcho_0293
RGE: RGE_41550
HHE: HH_0627(wlaK)
HMS: HMU06610
HCP: HCN_0250(wlaK)
HCB: HCBAA847_0255(wlaK)
WSU: WS2186(WLBC)
SULC: CVO_05535
CJU: C8J_0469
CJI: CJSA_0475
CJM: CJM1_0483(degT)
CJS: CJS3_0498
CJEJ: N564_00492
CJEU: N565_00540
CJEN: N755_00539
CJEI: N135_00555
CJER: H730_03415
CJY: QZ67_00515(wbpE)
CJQ: UC78_0492(wbpE)
CJR: CJE0612
CLA: CLA_1071
CCQ: N149_0497
CCF: YSQ_07315
CCY: YSS_02340
CCOI: YSU_06325
CCOF: VC76_02655(wbpE)
CCOO: ATE51_03192(wbpE)
CIS: CINS_1035
CVO: CVOL_1045
CPEL: CPEL_1175
CCUN: CCUN_0150
CAVI: CAV_0737
ABU: Abu_0664
AMAR: AMRN_0880
ATP: ATR_1359
HBV: ABIV_0866
SULJ: SJPD1_2062
NIS: NIS_1315
SUN: SUN_0095
GLO: Glov_1506
GEB: GM18_1435
DHY: DESAM_20955(degT)
DFL: DFE_2301
DAS: Daes_2980
DPI: BN4_12633(degT)
PPRF: DPRO_1442(wbpE)
LIP: LIC095
LIR: LAW_30093
DOL: Dole_1837
DAL: Dalk_5095
SAT: SYN_02671
SFU: Sfum_1293
BBA: Bd2251
BBW: BDW_06400
BEX: A11Q_1879
LABT: FIU93_11880(wbpE)
HNE: HNE_0783
HBA: Hbal_1842
GOX: GOX1922
ACR: Acry_1041
GDI: GDI2023
GDJ: Gdia_0247
GXY: GLX_26760
GXL: H845_619
KEU: S101446_03008(wbpE)
SHUM: STHU_26610
MAGX: XM1_0947
MAGN: WV31_12920
MGM: Mmc1_3738
CTC: CTC_01638
CBA: CLB_0875
CBH: CLC_0889
CBY: CLM_0977
CBL: CLK_0236
CBB: CLD_3738
CBI: CLJ_B0876
CBN: CbC4_0625
CBF: CLI_0916
CBM: CBF_0887
CBE: Cbei_2207
CBZ: Cbs_2207
CBEI: LF65_02497
CKL: CKL_1018
CKR: CKR_0922
CSQ: CSCA_2664
CLD: CLSPO_c08330(degT)
CTYK: CTK_C12290(degT)
HHW: NCTC503_00825(arnB_1)
OVA: OBV_05500
TACI: TDSAC_0188
NDA: Ndas_1451
NAL: B005_4231
STRR: EKD16_18835(wbpE2)
ALO: CRK59492
PUV: PUV_00150(degT)
WCH: wcw_1823(wbpE)
RUL: UC8_06000(wbpE_2) UC8_50190(wbpE_3)
TPED: TPE_0186
LIC: LIC_12197
LIS: LIL_12320(wecE4)
LBJ: LBJ_0463
LBL: LBL_2616
LBF: LBF_1016
LST: LSS_00210
BRM: Bmur_0965
BPW: WESB_0221
BIP: Bint_0303
ACA: ACP_3532
ABAS: ACPOL_2417
FSC: FSU_0637
PGI: PG_1138(porR)
PGN: PGN_1236(porR)
PGT: PGTDC60_1075(porR)
PDI: BDI_2790
TFO: BFO_0923(degT)
AFD: Alfi_0933
BACC: BRDCF_p497(degT)
BLQ: L21SP5_01619(wbpE)
RMR: Rmar_0724
FLN: FLA_0665
SGN: SGRA_1930
PHE: Phep_0549
HSW: Hsw_1632
GFO: GFO_0274
GFL: GRFL_2059
FJO: Fjoh_1727
FJG: BB050_00881(wbpE)
FBR: FBFL15_0441(porR)
FIN: KQS_11995(porR)
COC: Coch_0679
ZPR: ZPR_3684
RAI: RA0C_0600
RAR: RIA_1892
RAG: B739_1689
RAE: G148_1239
RAT: M949_2070
MARM: YQ22_10825
CBAL: M667_07380
CBAT: M666_07415
DDO: I597_0262(wbpE)
ZGA: ZOBELLIA_1739(fdtB) ZOBELLIA_2322(porR)
MLT: VC82_1862
NDO: DDD_1172
EAO: BD94_2011
ELB: VO54_00724(wbpE)
CHZ: CHSO_1825(degT2)
CTAK: 4412677_00062(btrR) 4412677_01093(arnB_2)
WIN: WPG_0781
TJE: TJEJU_0894(degT)
TMAR: MARIT_0517(degT)
AALG: AREALGSMS7_02203(wbpE)
KOS: KORDIASMS9_01913(wbpE)
KAN: IMCC3317_36810(wbpE)
MARF: CJ739_2071
FBA: FIC_00597
CPC: Cpar_1568
CCH: Cag_0448
CLI: Clim_1687
PVI: Cvib_1298
PLT: Plut_1482
PPH: Ppha_1093
CTS: Ctha_0570
TTK: TST_1661(wbpE)
CTHI: THC_1510
 » show all
Taxonomy
Reference
1  [PMID:19282284]
  Authors
Westman EL, McNally DJ, Charchoglyan A, Brewer D, Field RA, Lam JS
  Title
Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the  biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas  aeruginosa.
  Journal
J Biol Chem 284:11854-62 (2009)
DOI:10.1074/jbc.M808583200
  Sequence
[pae:PA3155]
Reference
2  [PMID:19348502]
  Authors
Larkin A, Imperiali B
  Title
Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1.
  Journal
Biochemistry 48:5446-55 (2009)
DOI:10.1021/bi900186u
  Sequence
[pae:PA3155]
Reference
3  [PMID:20604544]
  Authors
Larkin A, Olivier NB, Imperiali B
  Title
Structural analysis of WbpE from Pseudomonas aeruginosa PAO1: a nucleotide sugar  aminotransferase involved in O-antigen assembly.
  Journal
Biochemistry 49:7227-37 (2010)
DOI:10.1021/bi100805b
  Sequence
[pae:PA3155]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.98
IUBMB Enzyme Nomenclature: 2.6.1.98
ExPASy - ENZYME nomenclature database: 2.6.1.98
BRENDA, the Enzyme Database: 2.6.1.98
LinkDB All DBs

DBGET integrated database retrieval system