| Entry |
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| Name |
UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase;
WbpE;
WlbC
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| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
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| Sysname |
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate:2-oxoglutarate aminotransferase
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| Reaction(IUBMB) |
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate + 2-oxoglutarate = UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + L-glutamate [RN: R10141]
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| Reaction(KEGG) |
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| Substrate |
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate [CPD: C20359];
2-oxoglutarate [CPD: C00026]
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| Product |
UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate [CPD: C20395];
L-glutamate [CPD: C00025]
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| Comment |
A pyridoxal 5'-phosphate protein. This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide. The enzymes from Pseudomonas aeruginosa serotype O5 and Thermus thermophilus form a complex with the previous enzyme in the pathway, EC 1.1.1.335 (UDP-N-acetyl-2-amino-2-deoxyglucuronate oxidase).
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| History |
EC 2.6.1.98 created 2012
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| Pathway |
| ec00520 | Amino sugar and nucleotide sugar metabolism |
| ec00541 | O-Antigen nucleotide sugar biosynthesis |
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| Orthology |
| K13017 | UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Westman EL, McNally DJ, Charchoglyan A, Brewer D, Field RA, Lam JS |
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| Title |
Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Larkin A, Imperiali B |
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| Title |
Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Larkin A, Olivier NB, Imperiali B |
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| Title |
Structural analysis of WbpE from Pseudomonas aeruginosa PAO1: a nucleotide sugar aminotransferase involved in O-antigen assembly. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.6.1.98 |
| ExPASy - ENZYME nomenclature database: | 2.6.1.98 |
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| LinkDB |
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