EC 18.104.22.168 Enzyme
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase;
AMP-activated protein kinase;
HMG-CoA reductase kinase;
beta-hydroxy-beta-methylglutaryl-CoA reductase kinase;
[hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase;
3-hydroxy-3-methylglutaryl coenzyme A reductase kinase;
3-hydroxy-3-methylglutaryl-CoA reductase kinase;
hydroxymethylglutaryl coenzyme A reductase kinase;
hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating);
hydroxymethylglutaryl-CoA reductase kinase;
Transferring phosphorus-containing groups;
ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate [RN:
[hydroxymethylglutaryl-CoA reductase (NADPH)] [CPD:
[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate [CPD:
The enzyme is activated by AMP. EC
, hydroxymethylglutaryl-CoA reductase (NADPH) is inactivated by the phosphorylation of the enzyme protein. Histones can also act as acceptors. The enzyme can also phosphorylate hepatic acetyl-CoA carboxylase (EC
) and adipose hormone-sensitive lipase (EC
) . Thr-172 within the catalytic subunit (alpha-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase . GTP can act instead of ATP 
EC 22.214.171.124 created 1984 as EC 126.96.36.199, transferred 2005 to EC 188.8.131.52
Beg ZH, Stonik JA, Brewer HB Jr.
3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation.
Proc Natl Acad Sci U S A 75:3678-82 (1978)
Gibson DM, Ingebritsen TS.
Reversible modulation of liver hydroxymethylglutaryl CoA reductase.
Life Sci 23:2649-64 (1978)
Ingebritsen TS, Lee HS, Parker RA, Gibson DM.
Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation.
Biochem Biophys Res Commun 81:1268-77 (1978)
Ferrer A, Caelles C, Massot N, Hegardt FG.
Allosteric activation of rat liver microsomal [hydroxymethylglutaryl-CoA reductase (NADPH)]kinase by nucleoside phosphates.
Biol Chem Hoppe Seyler 368:249-57 (1987)
Weekes J, Ball KL, Caudwell FB, Hardie DG.
Specificity determinants for the AMP-activated protein kinase and its plant homologue analysed using synthetic peptides.
FEBS Lett 334:335-9 (1993)
Crute BE, Seefeld K, Gamble J, Kemp BE, Witters LA.
Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase.
J Biol Chem 273:35347-54 (1998)
Stein SC, Woods A, Jones NA, Davison MD, Carling D.
The regulation of AMP-activated protein kinase by phosphorylation.
Biochem J 345 Pt 3:437-43 (2000)
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