Entry
Name
hormone-sensitive lipase;
HSL
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
diacylglycerol acylhydrolase
Reaction(IUBMB)
(1) diacylglycerol + H2O = monoacylglycerol + a carboxylate [RN:
R05209 ];
(2) triacylglycerol + H2O = diacylglycerol + a carboxylate [RN:
R01369 ];
(3) monoacylglycerol + H2O = glycerol + a carboxylate [RN:
R07293 ]
Reaction(KEGG)
Substrate
Product
Comment
This enzyme is a serine hydrolase. Compared with other lipases, hormone-sensitive lipase has a uniquely broad substrate specificity. It hydrolyses all acylglycerols (triacylglycerol, diacylglycerol and monoacylglycerol) [2,3,4] as well as cholesteryl esters [2,4], steroid fatty acid esters [5], retinyl esters [6] and p-nitrophenyl esters [4,7]. It exhibits a preference for the 1- or 3-ester bond of its acylglycerol substrate compared with the 2-ester bond [8]. The enzyme shows little preference for the fatty acids in the triacylglycerol, although there is some increase in activity with decreasing chain length. The enzyme activity is increased in response to hormones that elevate intracellular levels of cAMP.
History
EC 3.1.1.79 created 2004
Orthology
K07188 hormone-sensitive lipase
Genes
GJA : 107106853(LIPE) 107117837
XLA : 100174796(lipe.L) 108697769(lipe.S)
DRE : 557893(lipeb) 568368(lipea)
SRX : 107706458 107723485 107739528 107748718
SANH : 107656618 107657706 107693390 107699484
SGH : 107565586 107593665 107595727 107599546
CCAR : 109105935 109105943 109111854 109111883
CAUA : 113059067 113062343 113116658 113120143
CGIB : 127935876 127975188 127979693 128030630
PTET : 122323687(lipea) 122360111(lipeb)
LROH : 127178636(lipeb) 127182269(lipea)
OMC : 131521393(lipeb) 131526328(lipea)
PPRM : 120483517(lipea) 120484659(lipeb)
RKG : 130097391(lipea) 130101863(lipeb)
MAMB : 125242790(lipeb) 125275320(lipea)
CIDE : 127497698 127500730
CERY : 137035350(lipeb) 137037589(lipea)
MASI : 127421249 127425486 127452857 127453560
TROS : 130557543(lipeb) 130567264(lipea)
TDW : 130415485(lipea) 130432801(lipeb)
MANU : 129448044(lipeb) 129455713(lipea)
PDAB : 135727643(lipeb) 135743260 135777858(lipea)
IPU : 108256376(lipeb) 108272659(lipea)
IFU : 128599999(lipeb) 128615553(lipea)
PHYP : 113532968(lipe) 113535092
SMEO : 124375514(lipeb) 124382218(lipea)
TFD : 113641262(lipea) 113659674(lipeb)
TVC : 132840266(lipeb) 132842902(lipea)
CGAR : 128514383(lipeb) 128515656(lipea)
NGRA : 132867322(lipeb) 132870905(lipea)
TRN : 134300957(lipeb) 134329520(lipea)
AMEX : 103030794(lipeb) 103036112(lipea)
CMAO : 118798741(lipeb) 118806054(lipea)
EEE : 113571934(lipe) 113578376
CHAR : 105902027(lipea) 105910643(lipeb)
SPIL : 134072147(lipea) 134082921(lipeb)
TRU : 101067661(lipe) 101070911
TFS : 130517918(lipea) 130519744(lipeb)
TNG : GSTEN00005445G001 GSTEN00015593G001
LCO : 104927333(lipe) 104928056
TBEN : 117477261(lipeb) 117478035(lipea)
CGOB : 115015627 115021198(lipe)
PGEO : 117455395(lipea) 117460354(lipeb)
GACU : 117549583(lipeb) 117559297(lipea)
EMAC : 134861718(lipeb) 134875241(lipea)
ELY : 117263762(lipea) 117265772(lipeb)
EFO : 125892771(lipeb) 125904660(lipea)
PLEP : 121945131(lipeb) 121958297(lipea)
SLUC : 116042460(lipeb) 116047175(lipea)
ECRA : 117945621(lipeb) 117957028(lipea)
ESP : 116691214(lipe) 116701791
PFLV : 114556966(lipe) 114567920
GAT : 120811071(lipeb) 120826336(lipea)
PPUG : 119197023(lipeb) 119218887(lipea)
AFB : 129097033(lipea) 129109404(lipeb)
CLUM : 117739107(lipea) 117745886(lipeb)
PSWI : 130207216(lipea) 130212720(lipeb)
CANA : 137780959(lipeb) 137784587(lipea)
CVE : 137872882(lipea) 137890933(lipeb)
MSAM : 119897337(lipeb) 119907925(lipea)
SCHU : 122864997(lipea) 122881968(lipeb)
CUD : 121513730(lipeb) 121524390(lipea)
SPUL : 138584009(lipeb) 138608444(lipea)
LMIX : 132983769(lipeb) 132991330(lipea)
ALAT : 119005801(lipeb) 119016736(lipea)
ASTR : 137601675(lipeb) 137607365(lipea)
MZE : 101473301 101485272(lipe)
ONL : 100534456(lipe) 100708083
OAU : 116309493(lipeb) 116318878(lipea)
OLA : 101157970(lipe) 101160745
OML : 112143493(lipeb) 112160867(lipea)
CSAI : 133436221(lipeb) 133460589 133460822
XMA : 102217205 102234893(lipe)
XCO : 114138258(lipe) 114156439
XHE : 116716805(lipe) 116731753
PRET : 103473021 103477914(lipe)
PFOR : 103139235(lipe) 103143485
PLAI : 106946893 106960167(lipe)
PMEI : 106916842(lipe) 106923653
GAF : 122830737(lipeb) 122843462(lipea)
PPRL : 129371269(lipeb) 129375786(lipea)
CTUL : 119771906(lipeb) 119781167(lipea)
GMU : 124865649(lipeb) 124879454(lipea)
NFU : 107379673(lipe) 107394884
KMR : 108229521(lipea) 108235517(lipeb)
ALIM : 106523738(lipe) 106530086
NWH : 119409953(lipeb) 119425963(lipea)
AOCE : 111564221(lipeb) 111580224(lipea)
EJA : 138194007(lipeb) 138215080(lipea)
BFRE : 138624036(lipeb) 138634189(lipea)
MCEP : 125016201(lipeb) 125020043(lipea)
CSEM : 103388799(lipe) 103393953
POV : 109633466(lipe) 109640422
SSEN : 122774381(lipeb) 122786205(lipea)
SSOE : 131447291(lipea) 131471034(lipeb)
HHIP : 117770234(lipea) 117777502(lipeb)
HSP : 118113590(lipeb) 118125101(lipea)
PPLT : 128449329(lipeb) 128461733(lipea)
SMAU : 118291618(lipea) 118303656(lipeb)
LCF : 108880754(lipeb) 108899366
SDU : 111230513 111236037(lipe)
SLAL : 111657262(lipe) 111661080
XGL : 120784156(lipeb) 120786574(lipea)
HCQ : 109513537 109531659(lipe)
SSCV : 125975658(lipeb) 137839748(lipea)
SBIA : 133492014(lipea) 133500518(lipeb)
PEE : 133395958(lipea) 133401367(lipeb)
PTAO : 133470940(lipea) 133479302(lipeb)
BPEC : 110168856 110174235(lipe)
ENY : 140362086(lipea) 140373447(lipeb)
MALB : 109954692(lipe) 109958776
BSPL : 114842682(lipeb) 114865425(lipea)
SJO : 128365788(lipeb) 128373760(lipea)
SSCO : 133983298(lipeb) 133996054(lipea)
GMH : 115535667 115553819(lipe)
SASA : 100380378(lips) 106570130 106577399 106605704
STRU : 115153499 115176102 115177356 115183447
OTW : 112226531(lipeb) 112230020(lipea) 112235274 112257644
OMY : 100505413(lipe1) 100505414(lipea) 110510088 110537667
OGO : 123998047 124018384 124038460 124043704(lipea)
ONE : 115112988 115120676 115131807
OKI : 109881762 109899918 109903781 109906657
OKE : 118371308 118378535 118397699 118398332(lipea)
OMM : 135512083 135520530 135521970 135550138(lipea)
OCLA : 139382045 139389858 139391816 139422822
SALP : 111955344 111958912 111978396
SNH : 120027276(lipea) 120046687 120048653 120048772
CCLU : 121575665 121586170
ELS : 105024275(lipe) 105027558 105028269
OEP : 134023459(lipeb) 134040734(lipea)
AROT : 135234452(lipeb) 135260411
CCOG : 133135787(lipeb) 133136399
PSPA : 121299176(lipeb) 121304208
ARUT : 117434050(lipeb) 117969359
DSI : Dsimw501_GD11499(Dsim_GD11499)
AALB : 109399347 109433364
PCLA : 123764980 138369772
RSAN : 119378685 119390381 119394211
TUT : 107359099 107361343 107362310 107362816 107368307 107370828 107371243
PMEO : 129581576 129590762
CEL : CELE_C46C11.1(hosl-1)
HRO : HELRODRAFT_111475 HELRODRAFT_161006
PMAX : 117320218 117341288
RPHI : 132723970 132746389
MBR : MONBRDRAFT_25836 MONBRDRAFT_34791
SRE : PTSG_06139 PTSG_08491
TET : TTHERM_00185900 TTHERM_00689920 TTHERM_00827140
PTM : GSPATT00000473001 GSPATT00006124001 GSPATT00010470001 GSPATT00014607001 GSPATT00014951001 GSPATT00015462001 GSPATT00015563001 GSPATT00020740001 GSPATT00023970001 GSPATT00027668001 GSPATT00031398001 GSPATT00032768001 GSPATT00034492001 PTMB.72
» show all
Taxonomy
Reference
Authors
Holm C, Osterlund T, Laurell H, Contreras JA.
Title
Molecular mechanisms regulating hormone-sensitive lipase and lipolysis.
Journal
Reference
Authors
Fredrikson G, Stralfors P, Nilsson NO, Belfrage P.
Title
Hormone-sensitive lipase of rat adipose tissue. Purification and some properties.
Journal
J Biol Chem 256:6311-20 (1981)
Reference
Authors
VAUGHAN M, BERGER JE, STEINBERG D.
Title
HORMONE-SENSITIVE LIPASE AND MONOGLYCERIDE LIPASE ACTIVITIES IN ADIPOSE TISSUE.
Journal
J Biol Chem 239:401-9 (1964)
Reference
Authors
Osterlund T, Danielsson B, Degerman E, Contreras JA, Edgren G, Davis RC, Schotz MC, Holm C.
Title
Domain-structure analysis of recombinant rat hormone-sensitive lipase.
Journal
Reference
Authors
Lee FT, Adams JB, Garton AJ, Yeaman SJ.
Title
Hormone-sensitive lipase is involved in the hydrolysis of lipoidal derivatives of estrogens and other steroid hormones.
Journal
Reference
Authors
Wei S, Lai K, Patel S, Piantedosi R, Shen H, Colantuoni V, Kraemer FB, Blaner WS.
Title
Retinyl ester hydrolysis and retinol efflux from BFC-1beta adipocytes.
Journal
Reference
Authors
Tsujita T, Ninomiya H, Okuda H.
Title
p-nitrophenyl butyrate hydrolyzing activity of hormone-sensitive lipase from bovine adipose tissue.
Journal
J Lipid Res 30:997-1004 (1989)
Reference
Authors
Yeaman SJ.
Title
Hormone-sensitive lipase--new roles for an old enzyme.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.79
ExPASy - ENZYME nomenclature database: 3.1.1.79
LinkDB
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