KEGG   ENZYME: 3.2.1.3Help
Entry
EC 3.2.1.3                  Enzyme                                 

Name
glucan 1,4-alpha-glucosidase;
glucoamylase;
amyloglucosidase;
gamma-amylase;
lysosomal alpha-glucosidase;
acid maltase;
exo-1,4-alpha-glucosidase;
glucose amylase;
gamma-1,4-glucan glucohydrolase;
acid maltase;
1,4-alpha-D-glucan glucohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
4-alpha-D-glucan glucohydrolase
Reaction(IUBMB)
Hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose
Reaction(KEGG)
(other) R01790 R01791 R06199(G)
Show
Comment
Most forms of the enzyme can rapidly hydrolyse 1,6-alpha-D-glucosidic bonds when the next bond in the sequence is 1,4, and some preparations of this enzyme hydrolyse 1,6- and 1,3-alpha-D-glucosidic bonds in other polysaccharides. This entry covers all such enzymes acting on polysaccharides more rapidly than on oligosaccharides. EC 3.2.1.20 alpha-glucosidase, from mammalian intestine, can catalyse similar reactions.
History
EC 3.2.1.3 created 1961
Pathway
ec00500  Starch and sucrose metabolism
ec01100  Metabolic pathways
Orthology
K01178  glucoamylase
K12047  maltase-glucoamylase
K21574  glucan 1,4-alpha-glucosidase
Genes
HSA: 8972(MGAM) 93432(MGAM2)
PTR: 463789(MGAM) 463790(MGAM2)
PPS: 100969261 100969608 100996199(MGAM)
GGO: 101127404(MGAM) 101131000(MGAM2)
PON: 100450850(MGAM) 100455657(MGAM2)
NLE: 100590310(MGAM) 100605801(MGAM2)
MCC: 695030(MGAM) 695370
MCF: 102120094(MGAM) 102122119(MGAM2)
CSAB: 103227040 103227042(MGAM) 103227409
RRO: 104655092 104655094 104659721(MGAM)
RBB: 108541550(MGAM) 108541557(MGAM2)
CJC: 100397043(MGAM2) 100397416(MGAM) 103794993
SBQ: 101054069(MGAM) 101054392
MMU: 232714(Mgam)
RNO: 103690059 312272(Mgam)
CGE: 100769016 100769303(Mgam2)
NGI: 103724791(Mgam2) 103726140(Mgam)
HGL: 101711183(Mgam) 101711548(Mgam2)
TUP: 102479933(MGAM) 102480355
CFA: 475523(MGAM) 482756(MGAM2)
AML: 100466340(MGAM2) 100466584(MGAM)
UMR: 103669012(MGAM) 103669102(MGAM2)
ORO: 101380291(MGAM) 101381158(MGAM2)
FCA: 101094582(MGAM) 101094837
PTG: 102963503(MGAM) 102963785(MGAM2)
AJU: 106970401(MGAM2) 106970446(MGAM)
BTA: 100296901 100336421(MGAM)
BOM: 102265977(MGAM) 102270662(MGAM2)
PHD: 102320366(MGAM)
CHX: 102179067(MGAM) 102180726(MGAM2)
OAS: 101113407(MGAM) 101113672(MGAM2)
SSC: 100623494(MGAM2) 102160115(MGAM)
CFR: 102514558(MGAM) 102514818(MGAM2)
CDK: 105097330 105097331(MGAM)
BACU: 103004683(MGAM)
LVE: 103081817(MGAM)
OOR: 101288403
ECB: 100064486(MGAM) 100065270(MGAM2)
EPZ: 103558278 103558279(MGAM)
EAI: 106842570(MGAM2) 106842605(MGAM)
MYB: 102255004(MGAM) 102262411(MGAM2)
MYD: 102758728(MGAM2) 102768888(MGAM)
HAI: 109395594(MGAM2) 109395610(MGAM)
RSS: 109457159 109457183(MGAM)
LAV: 100661007(MGAM2) 100661293(MGAM)
MDO: 100009833(MGAM)
OAA: 100093611
GGA: 425007(SI)
MGP: 100542024(SI)
ACYG: 106032152(SI) 106049821
TGU: 100189934(SI)
GFR: 102044952(SI)
FAB: 101807450(SI)
PHI: 102105067(SI) 102113603(MGAM)
PMAJ: 107198914 107208530(SI)
CCW: 104688154(SI)
FPG: 101919765(SI)
FCH: 102046830(SI)
AMJ: 102559297(MGAM)
PSS: 102452896(SI)
CMY: 102948110(SI)
CPIC: 101936465(SI)
ACS: 100563205(si)
PVT: 110085330(MGAM)
PBI: 103065815
GJA: 107110072(SI)
XLA: 108717032
XTR: 100379714(mgam)
NPR: 108797771(MGAM)
DRE: 100148922(si)
CCAR: 109063204
IPU: 108264758
TRU: 101063256
NCC: 104966325
OLA: 101164831(si)
XMA: 102216935(si)
PRET: 103474416(si)
CSEM: 103377566(si)
LCF: 108886343(si)
HCQ: 109525537
BPEC: 110174480
SASA: 106613210
ELS: 105028748
SFM: 108924670(si)
LCM: 102351524(SI)
CMK: 103175535(si)
CIN: 100175461(mgam)
SPU: 592667(mgam)
TSP: Tsp_03950
MYI: 110466703
EPA: 110239595
ADF: 107336647
SCE: YIL099W(SGA1)
ERC: Ecym_3314
KMX: KLMA_80141(SGA1)
NCS: NCAS_0G03900(NCAS0G03900)
NDI: NDAI_0G00580(NDAI0G00580)
TPF: TPHA_0D01570(TPHA0D01570)
TBL: TBLA_0B06900(TBLA0B06900)
TDL: TDEL_0C03860(TDEL0C03860)
KAF: KAFR_0H03370(KAFR0H03370)
PIC: PICST_28187(WSC3) PICST_30325(MUC1.11) PICST_33726(SGA1)
CAL: CAALFM_C301320CA(SGA1)
CAUR: QG37_02393
SLB: AWJ20_4030(SGA1)
NCR: NCU01517(gla-1)
NTE: NEUTE1DRAFT117282(NEUTE1DRAFT_117282)
MTM: MYCTH_72393(gla1)
MGR: MGG_01096
MAW: MAC_09504
MAJ: MAA_01177
CMT: CCM_08811
ANG: ANI_1_820034(An03g06550)
ABE: ARB_02327
TVE: TRV_05045
PTE: PTT_17668
ZTR: MYCGRDRAFT_42503(MgSGA1)
SPO: SPBC14C8.05c(meu17)
CNE: CNE02630
CNB: CNBE2650
ABP: AGABI1DRAFT112487(AGABI1DRAFT_112487)
ABV: AGABI2DRAFT192455(AGABI2DRAFT_192455)
SMIN: v1.2.019140.t2(symbB.v1.2.019140.t2) v1.2.021811.t1(symbB.v1.2.021811.t1) v1.2.024326.t1(symbB.v1.2.024326.t1) v1.2.027250.t1(symbB.v1.2.027250.t1)
PAM: PANA_4020(cga)
PLF: PANA5342_p10157(cga)
PAJ: PAJ_p0267(cga)
PAQ: PAGR_p107
PSI: S70_09615
PSX: DR96_1259
PSD: DSC_09960
SON: SO_2459(cga)
SDN: Sden_2004
SFR: Sfri_1775
SAZ: Sama_1656
SLO: Shew_1873
SWD: Swoo_2201
SWP: swp_2682
SPSW: Sps_00669
PSM: PSM_A1382
PSEO: OM33_09840
PSPO: PSPO_a1446
PART: PARC_a2295
PSEN: PNC201_07035(cga)
CJA: CJA_0731(gla15)
SDE: Sde_0600
LPN: lpg0422(legY)
LPH: LPV_0523
LPO: LPO_0482
LPM: LP6_0415(legY)
LPF: lpl0465
LPP: lpp0489
LPC: LPC_2921
LPA: lpa_00657
LPE: lp12_0425
LLO: LLO_2801
LFA: LFA_2690(legY)
LHA: LHA_1522(legY)
SLIM: SCL_2736
CVI: CV_3490
BPS: BPSS0144
BPSE: BDL_6035(cga)
BPSM: BBQ_3542(cga)
BPSU: BBN_6057(cga)
BPSD: BBX_5204(cga)
BPK: BBK_5336(cga)
BPSH: DR55_5219(cga)
BPSA: BBU_3428(cga)
BPSO: X996_4987(cga)
BUT: X994_4535(cga)
BTQ: BTQ_3507(cga)
BTJ: BTJ_4544(cga)
BTZ: BTL_5329(cga)
BTD: BTI_4648(ga1)
BTV: BTHA_4870(cga)
BTHE: BTN_5002(cga)
BTHM: BTRA_5270(cga)
BTHA: DR62_5130
BTHL: BG87_5337(cga)
BOK: DM82_3805(ga1)
BOC: BG90_4237(ga1)
BUB: BW23_4104(cga)
BUL: BW21_4173(ga1)
BBAG: E1O_11080
SLT: Slit_0396
DEU: DBW_0825(cga)
SCL: sce0768 sce4027(cga1) sce4102(cga2)
MLO: mlr4205
SMD: Smed_5985
ATU: Atu4833(cga)
ATF: Ach5_28610(cga)
AVI: Avi_7572
NHA: Nham_0995
SNO: Snov_3673
BID: Bind_3431
MSL: Msil_0405
RVA: Rvan_2699
MMED: Mame_04695(cga)
MCG: GL4_3188
HDI: HDIA_2395(amyD)
CCR: CC_2282
CAK: Caul_4086
CSE: Cseg_2936
PAMN: pAMV3p0493
RSU: NHU_02604
RRU: Rru_A3302
RRF: F11_16915
AFR: AFE_2224 AFE_2482(cga)
TTE: TTE1813
TTM: Tthe_0773
TSH: Tsac_1365
KAL: KALB_3234
ACTN: L083_3633
CAI: Caci_7155
GLJ: GKIL_4247
ANA: alr1586
AVA: Ava_4198
RCA: Rcas_2590
CAG: Cagg_3494
DGE: Dgeo_0725
TSC: TSC_c11240(cga)
PUV: PUV_11830(cga)
ACA: ACP_2274
ABAS: ACPOL_5341
BTH: BT_3703(susB) BT_4581
BFR: BF1191
BFS: BF9343_1099(susB)
BFG: BF638R_1205(susB)
BVU: BVU_1381
TFO: BFO_2272
PRU: PRU_2750(susB)
AFD: Alfi_1931
ASH: AL1_00490
DORI: FH5T_04430
MBAS: ALGA_0720
CPI: Cpin_5767
CHU: CHU_0399
SLI: Slin_0058
LBY: Lbys_3382
GFO: GFO_3444(susB)
GFL: GRFL_1054
FBR: FBFL15_2614(susB)
FIN: KQS_01095
ZPR: ZPR_2817
RAI: RA0C_0229
RAR: RIA_0120
RAG: B739_2091
RAE: G148_1605
RAT: M949_0302
ZGA: ZOBELLIA_368(susB) ZOBELLIA_3886(cgaA)
MLT: VC82_116
NDO: DDD_0980(susB)
CHZ: CHSO_1790
SPON: HME9304_02369(malZ)
KOS: KORDIASMS9_01037(susB)
MARF: CJ739_2459
FBA: FIC_00545
FBU: UJ101_01032(malZ)
IAL: IALB_2597
CDIV: CPM_0471
HMA: rrnAC2353(cga-2)
SSO: SSO2473
 » show all
Taxonomy
Reference
1  [PMID:14803428]
  Authors
FRENCH D, KNAPP DW.
  Title
The maltase of Clostridium acetobutylicum; its specificity range and mode of action.
  Journal
J Biol Chem 187:463-71 (1950)
Reference
2  [PMID:4286143]
  Authors
Brown BI, Brown DH.
  Title
The subcellular distribution of enzymes in type II glycogenosis and the occurrence of an oligo-alpha-1,4-glucan glucohydrolase in human tissues.
  Journal
Biochim Biophys Acta 110:124-33 (1965)
Reference
3  [PMID:4313883]
  Authors
Jeffrey PL, Brown DH, Brown BI.
  Title
Studies of lysosomal alpha-glucosidase. I. Purification and properties of the rat liver enzyme.
  Journal
Biochemistry 9:1403-15 (1970)
Reference
4  [PMID:4743896]
  Authors
Kelly JJ, Alpers DH.
  Title
Properties of human intestinal glucoamylase.
  Journal
Biochim Biophys Acta 315:113-22 (1973)
DOI:10.1016/0005-2744(73)90135-6
Reference
5  [PMID:13373867]
  Authors
COPELAND WH, MILLER KD.
  Title
A blood trans-alpha-glucosylase.
  Journal
Biochim Biophys Acta 22:193-4 (1956)
DOI:10.1016/0006-3002(56)90242-6
Reference
6  [PMID:13517301]
  Authors
TSUJISAKA Y, FUKUMOTO J, YAMAMCTO T.
  Title
Specificity of crystalline saccharogenic amylase of moulds.
  Journal
Nature 181:770-1 (1958)
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.3
IUBMB Enzyme Nomenclature: 3.2.1.3
ExPASy - ENZYME nomenclature database: 3.2.1.3
BRENDA, the Enzyme Database: 3.2.1.3
CAS: 9032-08-0
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