KEGG   ENZYME: 3.3.2.15
Entry
EC 3.3.2.15                 Enzyme                                 

Name
trans-2,3-dihydro-3-hydroxyanthranilic acid synthase;
isochorismatase (ambiguous);
phzD (gene name)
Class
Hydrolases;
Acting on ether bonds;
Ether hydrolases
Sysname
(2S)-2-amino-4-deoxychorismate pyruvate-hydrolase
Reaction(IUBMB)
(2S)-2-amino-4-deoxychorismate + H2O = (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate + pyruvate [RN:R11463]
Reaction(KEGG)
R11463
Substrate
(2S)-2-amino-4-deoxychorismate [CPD:C18054];
H2O [CPD:C00001]
Product
(5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxylate [CPD:C19830];
pyruvate [CPD:C00022]
Comment
Isolated from the bacterium Pseudomonas aeruginosa. Involved in phenazine biosynthesis.
History
EC 3.3.2.15 created 2016
Pathway
ec00405  Phenazine biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20261  trans-2,3-dihydro-3-hydroxyanthranilic acid synthase
Genes
SFW: WN53_03390
PATR: EV46_13200
PATO: GZ59_18580(ehpB)
LAB: LA76x_3334(phzD1)
LAQ: GLA29479_2367(phzD1)
PAE: PA1902(phzD2) PA4213(phzD1)
PAEV: N297_1962 N297_4345
PAEI: N296_1962 N296_4345
PAU: PA14_09450(phzD1) PA14_39925(phzD2)
PAP: PSPA7_0886 PSPA7_3382
PAG: PLES_07141(phzD1) PLES_34221(phzD2)
PAF: PAM18_0724(phzD1) PAM18_3140(phzD2)
PAEU: BN889_06463(phzD1_1) BN889_06777(phzD1_3) BN889_07359(phzD1_6)
PFB: VO64_0337
PSET: THL1_3621
BGU: KS03_4992
BVR: BVIR_2863
MAB: MAB_0297
MABB: MASS_0298
MCHE: BB28_01465
MSAL: DSM43276_00252(phzD_1)
RFA: A3L23_00644(phzD)
RHS: A3Q41_02711(phzD)
TPR: Tpau_0113
SALB: XNR_0597
SALS: SLNWT_4919
SGU: SGLAU_17220(phzA)
STRM: M444_18420
SRN: A4G23_05417(phzD)
STRD: NI25_24440
NDA: Ndas_5030
NAL: B005_4272(dhbB)
STRR: EKD16_18440(phzD)
ALO: CRK58740
 » show all
Reference
1  [PMID:11591691]
  Authors
Mavrodi DV, Bonsall RF, Delaney SM, Soule MJ, Phillips G, Thomashow LS
  Title
Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1.
  Journal
J Bacteriol 183:6454-65 (2001)
DOI:10.1128/JB.183.21.6454-6465.2001
  Sequence
Reference
2  [PMID:12741825]
  Authors
Parsons JF, Calabrese K, Eisenstein E, Ladner JE
  Title
Structure and mechanism of Pseudomonas aeruginosa PhzD, an isochorismatase from the phenazine biosynthetic pathway.
  Journal
Biochemistry 42:5684-93 (2003)
DOI:10.1021/bi027385d
  Sequence
[pae:PA1902]
Other DBs
ExplorEnz - The Enzyme Database: 3.3.2.15
IUBMB Enzyme Nomenclature: 3.3.2.15
ExPASy - ENZYME nomenclature database: 3.3.2.15
BRENDA, the Enzyme Database: 3.3.2.15
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