Entry |
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Name |
angiotensin-converting enzyme 2;
ACE-2;
ACE2;
hACE2;
angiotensin converting enzyme 2;
angiotensin converting enzyme-2;
Tmem27
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Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
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Reaction(IUBMB) |
angiotensin II + H2O = angiotensin-(1--7) + L-phenylalanine [RN: R09535]
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Reaction(KEGG) |
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Substrate |
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Product |
angiotensin-(1--7);
L-phenylalanine [CPD: C00079]
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Comment |
A transmembrane glycoprotein with an extracellular catalytic domain. Angiotensin-converting enzyme 2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates [2]. Catalytic efficiency is 400-fold higher with angiotensin II (1--8) as a substrate than with angiotensin I (1--10). Angiotensin-converting enzyme 2 also efficiently hydrolyses des-Arg9-bradykinin, but it does not hydrolyse bradykinin [1]. In peptidase family M2.
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History |
EC 3.4.17.23 created 2009
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Orthology |
K09708 | angiotensin-converting enzyme 2 |
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Genes |
» show all
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Reference |
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Authors |
Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, Godbout K, Parsons T, Baronas E, Hsieh F, Acton S, Patane M, Nichols A, Tummino P |
Title |
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. |
Journal |
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Sequence |
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Reference |
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Authors |
Lambert DW, Hooper NM, Turner AJ |
Title |
Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system. |
Journal |
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Reference |
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Authors |
Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW |
Title |
ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 3.4.17.23 |
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LinkDB |
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