KEGG   ENZYME: 4.1.1.82
Entry
EC 4.1.1.82                 Enzyme                                 
Name
phosphonopyruvate decarboxylase;
3-phosphonopyruvate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
3-phosphonopyruvate carboxy-lyase (2-phosphonoacetaldehyde-forming)
Reaction(IUBMB)
3-phosphonopyruvate = 2-phosphonoacetaldehyde + CO2 [RN:R04053]
Reaction(KEGG)
R04053
Substrate
3-phosphonopyruvate [CPD:C02798]
Product
2-phosphonoacetaldehyde [CPD:C03167];
CO2 [CPD:C00011]
Comment
The enzyme catalyses a step in the biosynthetic pathway of 2-aminoethylphosphonate, a component of the capsular polysaccharide complex of Bacteroides fragilis. Requires thiamine diphosphate and Mg2+ as cofactors. The enzyme is activated by the divalent cations Mg2+, Ca2+ and Mn2+. Pyruvate and sulfopyruvate can also act as substrates, but more slowly. This enzyme drives the reaction catalysed by EC 5.4.2.9, phosphoenolpyruvate mutase, in the thermodynamically unfavourable direction of 3-phosphonopyruvate formation [2]. It is the initial step in all of the major biosynthetic pathways of phosphonate natural products [3].
History
EC 4.1.1.82 created 2005
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K09459  phosphonopyruvate decarboxylase
Genes
ZNE: 110841498
CSEC: 111875044
PAME: 138707993
SGRE: 126298672
BROR: 134540720
HAMR: 139696869
FCD: 110847575
PPOI: 119111117 119111763
LGI: LOTGIDRAFT_114966
PVUL: 126824792
PCAN: 112559357
LSAX: 138971147
HRJ: 124268737
HASI: 137261656
HCRA: 139467095
OED: 125646416
MYI: 110448928
PMAX: 117336379
AIRR: 138329465
MCAF: 127705869
MMER: 123537598
RPHI: 132722180
DPOL: 127847049 127877104
MAEA: 128231744
OBI: 106874397
LJP: 135468502
LAK: 106157387 106176585
NVE: 5511287
EPA: 110243717
ATEN: 116287539
ADF: 107333309
AMIL: 114948801
MCAZ: 138018762
MFOO: 137999732 137999740
PDAM: 113684314
SPIS: 111344557
DGT: 114523267
XEN: 124452918
HMG: 100197891
HSY: 130629280
RES: 135680883
TET: TTHERM_01287980
PTM: GSPATT00025990001 GSPATT00026172001
TBR: Tb11.01.1120
TBG: TbgDal_XI10470
TCR: 505965.50
HDE: HDEF_0202
BSEL: RHD99_08495(aepY)
SRL: SOD_c30100(bcpC)
SRY: M621_16410
FSM: CCS41_00900(aepY)
PROD: PCO85_08035(aepY)
ECA: ECA0488(fom2)
PATR: EV46_02525
PATO: GZ59_05040(fom2)
PCT: PC1_0477
PCC: PCC21_005020
PWA: Pecwa_0573
PPAR: A8F97_15525
PEC: W5S_0591
PPOA: BJK05_19420
PPUJ: E2566_02930(aepY)
PARI: I2D83_19360(aepY)
PCAC: OI450_03790(aepY)
PCOA: PJ912_15830(aepY)
PPEU: DUT67_19405(aepY)
LBQ: CKQ53_06555(aepY)
LPOP: I6N93_15655(aepY)
EPE: CI789_05495(aepY)
PLF: PANA5342_2584(ppd)
PAJ: PAJ_2521
PAQ: PAGR_g3819
EIC: NT01EI_2702
XVA: C7V42_03525(aepY)
XHY: FZ025_12105(aepY)
XDY: NYR95_03915(aepY)
PTRE: I9H09_23710(aepY)
PPZ: H045_01955
SDN: Sden_1162
PMAW: MACH26_33040
OSG: BST96_06900
NOC: Noc_1316
NHL: Nhal_1305
NWA: Nwat_1198
NWR: E3U44_16830(aepY)
NTT: TAO_1302
NTG: NSCAC_0557(ppd)
ZPL: ZBT109_1639
MPRF: J8N69_05405(aepY)
SALN: SALB1_2155
RPJ: N234_04635
RME: Rmet_1809(ppd)
CBW: RR42_s0340
CPAU: EHF44_14445(aepY)
COX: E0W60_18820(aepY)
CCAM: M5D45_07520(aepY)
CUPE: KLP38_07745(aepY)
CUPP: CTP10_R63670(aepY)
BMA: BMAA1769(ppd)
BMV: BMASAVP1_0759(ppd)
BMAZ: BM44_3973(aepY)
BMAL: DM55_4013(aepY)
BMAQ: DM76_4709(aepY)
BMAI: DM57_07160
BMAF: DM51_3462(aepY)
BMAB: BM45_4750(aepY)
BPS: BPSS0508 BPSS0609
BPM: BURPS1710b_A2064(ppd) BURPS1710b_A2172(fom2)
BPL: BURPS1106A_A0690(ppd) BURPS1106A_A0817(ppd)
BPD: BURPS668_A0779(aepY_2) BURPS668_A0909(aepY_1)
BPR: GBP346_B0096(aepY_1) GBP346_B3362(aepY_2)
BPSE: BDL_3734(aepY) BDL_3836(aepY)
BPSM: BBQ_5586(aepY) BBQ_5688(aepY)
BPSU: BBN_3908(aepY) BBN_4008(aepY)
BPSD: BBX_5571(aepY) BBX_5673(aepY)
BPZ: BP1026B_II0563 BP1026B_II0673
BPQ: BPC006_II0734 BPC006_II0865
BPK: BBK_3882(aepY) BBK_5713(aepY)
BPSH: DR55_4743(aepY) DR55_4844(aepY)
BPSA: BBU_5437(aepY) BBU_5539(aepY)
BPSO: X996_3789(aepY) X996_4594(aepY)
BUT: X994_4010(aepY) X994_4112(aepY)
BTE: BTH_II1909
BTQ: BTQ_5191(aepY)
BTJ: BTJ_3821(aepY)
BTZ: BTL_4577(aepY) BTL_4677(aepY)
BTD: BTI_5337(aepY)
BTV: BTHA_5552(aepY)
BTHE: BTN_4316(aepY)
BTHM: BTRA_4581(aepY)
BTHA: DR62_4262 DR62_4365
BTHL: BG87_4648(aepY)
BOK: DM82_4610(aepY) DM82_4704(aepY)
BOC: BG90_5889(aepY) BG90_5981(aepY)
BUU: WS70_20050
BSAV: WS86_21235 WS86_21650
BHG: I6G56_25500(aepY)
BUD: AQ610_28105
BVI: Bcep1808_4686
BVE: AK36_4233(aepY)
BUR: Bcep18194_B1915
BCM: Bcenmc03_3399
BCH: Bcen2424_4120
BCJ: BCAM1244
BCEN: DM39_3754(aepY)
BCEW: DM40_4162(aepY)
BCEO: I35_5093
BAM: Bamb_3534
BAC: BamMC406_4015
BMJ: BMULJ_04038(ppd)
BMU: Bmul_4472
BMK: DM80_3633(aepY)
BMUL: NP80_4147(aepY)
BCT: GEM_4496
BCED: DM42_3847(aepY)
BCEP: APZ15_18455
BDL: AK34_4231(aepY)
BPYR: ABD05_29920
BCON: NL30_06375
BUB: BW23_4918(aepY)
BDF: WI26_19320
BLAT: WK25_23145
BTEI: WS51_03915
BSEM: WJ12_26080
BPSL: WS57_07795
BMEC: WJ16_24705
BSTG: WT74_25010
BSTL: BBJ41_19210
BANN: JFN94_23425(aepY)
BARI: NLX30_32415(aepY)
BAEN: L3V59_19230(aepY)
BSER: R0290_25565(aepY)
BGL: bglu_2g13470
BGU: KS03_4594(aepY)
BUG: BC1001_5204
BGF: BC1003_4279
BGD: bgla_2g13350
BGO: BM43_5002(aepY)
BYI: BYI23_A006820
BUK: MYA_4543
BUL: BW21_5017(aepY)
BUQ: AC233_24005
BGP: BGL_2c11760
BPLA: bpln_2g12600
BUM: AXG89_10165
BUI: AX768_03890
BURK: DM992_19620(aepY)
BURT: BTHE68_06830
BURM: GJG85_17380(aepY)
BXE: Bxe_B2234
BXB: DR64_4565(aepY)
BPH: Bphy_3821
BGE: BC1002_3394
BPX: BUPH_05877
BPY: Bphyt_5998
BUZ: AYM40_23415
BFN: OI25_4535(aepY)
BCAI: K788_0000150
PSPW: BJG93_18655(aepY)
PARA: BTO02_27440
PARB: CJU94_32425(aepY)
PHS: C2L64_30755(aepY)
PTER: C2L65_27415(aepY)
PGP: CUJ91_19560(aepY)
PCJ: CUJ87_30245(aepY)
PTS: CUJ90_26945(aepY)
PCAF: DSC91_002023
PMEG: FNZ07_08535(aepY)
PTRO: G5S35_19395(aepY)
PGIS: I6I06_19280(aepY)
PACP: FAZ97_15195(aepY)
PACS: FAZ98_20210(aepY)
PEW: KZJ38_30040(aepY)
PDIO: PDMSB3_0866.1(ppd)
PBRY: NDK50_32645(aepY)
PSAA: QEN71_14450(aepY)
PKF: RW095_11995(aepY)
PBON: QS306_15250(aepY)
PPAI: E1956_23910(aepY)
PLAD: PPGU16_43950
PAZZ: PBP221_52660(aepY)
PPK: U875_16970
PPNO: DA70_09040
PPNM: LV28_21765
PRB: X636_17450
PPUL: RO07_16155
PSPU: NA29_20995
PAPI: SG18_00145
PVE: UC34_07415
POX: MB84_11755
PFG: AB870_18105
PNR: AT302_26650
PAND: DRB87_06675(aepY)
PFIB: PI93_020430(aepY)
PCOM: NTU39_08425(aepY)
PANN: PanNE5_00510
PANX: OYT13_06675(aepY)
CABA: SBC2_10690
BUO: BRPE64_ACDS07740
CABK: NK8_07540(aepY)
BUE: BRPE67_ACDS06760
TCAR: U0034_22535(aepY)
AAA: Acav_2123
MEU: ACJ67_08965
MMEC: FIU01_07275(aepY)
AZO: azo2699
AOA: dqs_2834
AVI: Avi_3414
REP: IE4803_PB00124
ARA: Arad_7868
AOL: S58_09490
BROS: QUH67_10085(aepY)
TARV: FIU28_02595(aepY)
SIW: GH266_09710(aepY)
LCK: HN018_01550(aepY)
RGI: RGI145_09785
ROS: CTJ15_07645(aepY)
RMUC: FOB66_09670(aepY)
RMT: IAI58_18635(aepY)
AZZ: DEW08_28015(aepY)
ECOG: FIV45_08010(aepY)
SNEA: NBZ79_03290(aepY)
HWI: A0Z60_07475(aepY)
CJU: C8J_1330
CHYO: CHH_1592
CHW: A2J15_004810(aepY)
CINF: CINF_1347
ANT: Arnit_2942
DLM: DPPLL_12500
DAK: DaAHT2_1859
ESD: SD837_15210(aepY)
DAL: Dalk_1322
DLI: dnl_05850
DAO: Desac_2269
LLU: AKJ09_10388
BSTO: C0V70_16035(aepY)
OTE: Oter_2977
OBG: Verru16b_03221
ELUT: CKA38_13740(aepY)
TDE: TDE_1414
TBE: Trebr_0278
TPI: TREPR_2365(aepY)
TPK: JO40_09720
TPHG: FUT81_06850(aepY)
TRI: DYE50_04585(aepY)
TPAV: HRQ91_06195(aepY)
TSK: HRI97_05660(aepY)
SSM: Spirs_4229
STA: STHERM_c15600
SBU: SpiBuddy_0273
SGP: SpiGrapes_1559
TAZ: TREAZ_2215(aepY)
SCD: Spica_1332
BHC: JFL75_01535(aepY)
TPX: Turpa_2339
BIP: Bint_1238
FSU: Fisuc_0992
FSC: FSU_1438
BTH: BT_1719
BTHO: Btheta7330_01296(ilvB)
BFR: BF1833 BF2577
BFS: BF9343_1815(aepY)
BFG: BF638R_1868
BUN: Bun01g_29030
BEG: INE88_02863
BSTE: K6V31_00390(aepY)
BDO: EL88_10430
PARC: CI960_12855(aepY)
PCOI: LK433_14485(aepY)
DRC: G0Q07_19265(aepY)
PCM: AY601_0433
FUV: JR347_10755(aepY)
RCG: N7E81_15225(aepY)
FAX: FUAX_43920
TSX: RHP49_06900(aepY)
PROC: Ptc2401_00815(ilvB_1)
NDE: NIDE2902(ppd)
NKF: Nkreftii_003418
NVA: G3M78_03285(aepY)
BACI: B1NLA3E_03310
BMQ: BMQ_0785(aepY)
BMD: BMD_0786(aepY)
BMH: BMWSH_4463(ppd)
BMEG: BG04_3079(aepY)
MEKU: HUW50_16410(aepY)
MRL: WCV66_23095(aepY)
BOU: I5818_22335(aepY)
PTB: DER53_11740(aepY)
PCAL: BV455_03447
BLR: BRLA_c034000
BRW: GOP56_09090(aepY)
PPY: PPE_04395 PPE_04790
PPOL: X809_41425
PTA: HPL003_06760
PIH: UB51_20095 UB51_20635
PPEO: ABE82_25175
PKB: B4V02_00180 B4V02_16730
PAIH: ASL14_12570
PLUT: EI981_13660(aepY)
PCHI: PC41400_18310(aepY)
PTHI: NDS46_01340(aepY)
PKA: PQ456_19755(aepY)
PNK: AASFL403_21925
PHEX: L0M14_27415(aepY)
PACL: DCC85_01110(aepY)
PELG: ACJ7K1_23165(aepY)
ANEU: PP175_10610(aepY) PP175_13690(aepY)
ADAU: NZD86_21655(aepY)
EFF: skT53_29660
SURL: BI350_13785
PABS: JIR001_16500
CTC: CTC_01699
CTET: BN906_01841
CBJ: H04402_02797
CBE: Cbei_4337
CBZ: Cbs_4337
CBEI: LF65_04861
CSR: Cspa_c46180(bcpC)
CSB: CLSA_c08740(bcpC)
CBUT: ATN24_05945
CARG: RSJ17_12815
CDY: F3K33_22180(aepY)
CCAA: KQH81_02880(aepY)
CNN: CNEO_1088(ppd)
CGEL: psyc5s11_47360
CLOL: ONV75_04640(aepY)
RAL: Rumal_1341
RCH: RUM_11410
ALAC: JYE50_04505(aepY) JYE50_12335(aepY)
AHC: JYE49_05000(aepY)
BPEN: NQ488_09085(aepY)
CBAF: JS518_04520(aepY) JS518_12265(aepY)
RRK: H8S51_002425(aepY)
BPRO: PMF13cell1_05127(mdlC)
BCOC: BLCOC_42160
HHJ: NQ487_01305(aepY)
LBP: V1224_02260(aepY)
CLE: Clole_3575
HAS: Halsa_0039
TIZ: RBU61_14845(aepY)
SSG: Selsp_0558
SELE: ADJ74_04655
SELO: AXE86_05285
SELT: BCS37_10940
SDIA: QU667_11315(aepY)
STIM: H1B31_02565(aepY)
SELM: TAMA11512_22120(aepY)
LCG: L3BBH23_02730
MBJ: KQ51_00728
OLS: Olsu_0592
NBR: O3I_021400
NTP: CRH09_19450(aepY)
NOZ: DMB37_08000(aepY)
NAH: F5544_23985
NVU: V7968_29235(aepY)
SCO: SCO6824(SC4A9.01c)
SALS: SLNWT_3224
STRC: AA958_29495
STRT: A8713_00490
SGS: AVL59_02545
SALW: CP975_03130(aepY)
SALF: SMD44_04408
SRJ: SRO_1309
SGD: ELQ87_04605
SGF: HEP81_01275
SSEO: D0Z67_12190(aepY)
SRIM: CP984_37455(aepY)
STSU: B7R87_30295
SDW: K7C20_15035(aepY)
SGOB: test1122_07760(aepY)
SCIR: STRCI_003016(aepY)
STTN: BSL84_13970
SCAY: PYS65_02420(aepY)
SPRF: K4G22_27920(aepY)
SCAT: P8A18_04910(aepY)
LSE: F1C12_11065
RTC: APU90_00560
CELH: GXP71_14040(aepY)
TES: BW730_00190
NAKE: KGD83_08790(aepY)
SAIU: J4H86_04285(aepY)
FAL: FRAAL6378
AMYY: YIM_29485
SSYI: EKG83_20795(aepY)
KUT: JJ691_31280
AAUR: V5P93_003511
MPRN: Q3V37_07940(aepY)
ASIC: Q0Z83_111410(aepY)
AOU: ACTOB_005082(aepY)
NHY: JQS43_02330(aepY)
SNA: Snas_5664
NAV: JQS30_13660(aepY)
AYM: YM304_30160
ARP: NIES39_A00300
MPRO: BJP34_15510
NED: HUN01_29210(aepY)
NLK: NIES25_38250
NCF: ANSO36C_01090
NOSQ: PQG02_25445(aepY)
MDP: NIES3275_60660
TOQ: HCG51_21870(aepY)
SCYT: SAMD_46610
NCN: BZZ01_05230
LMAJ: GKN94_04165(aepY)
MARW: MNSC_08270(aepY)
METB: AW729_03840
TAR: TALC_00082
LOB: NEF87_004218
PSYT: DSAG12_01621(aepY)
 » show all
Reference
1  [PMID:12904299]
  Authors
Zhang G, Dai J, Lu Z, Dunaway-Mariano D.
  Title
The phosphonopyruvate decarboxylase from Bacteroides fragilis.
  Journal
J Biol Chem 278:41302-8 (2003)
DOI:10.1074/jbc.M305976200
Reference
2  [PMID:8180189]
  Authors
Seidel HM, Knowles JR.
  Title
Interaction of inhibitors with phosphoenolpyruvate mutase: implications for the reaction mechanism and the nature of the active site.
  Journal
Biochemistry 33:5641-6 (1994)
DOI:10.1021/bi00184a037
Reference
3  [PMID:9127192]
  Authors
Nakashita H, Watanabe K, Hara O, Hidaka T, Seto H
  Title
Studies on the biosynthesis of bialaphos. Biochemical mechanism of C-P bond formation: discovery of phosphonopyruvate decarboxylase which catalyzes the formation of phosphonoacetaldehyde from phosphonopyruvate.
  Journal
J Antibiot (Tokyo) 50:212-9 (1997)
DOI:10.7164/antibiotics.50.212
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.82
IUBMB Enzyme Nomenclature: 4.1.1.82
ExPASy - ENZYME nomenclature database: 4.1.1.82
BRENDA, the Enzyme Database: 4.1.1.82
CAS: 151662-34-9
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