| Entry |
|
|---|
| Name |
N-acetylneuraminate lyase;
N-acetylneuraminic acid aldolase;
acetylneuraminate lyase;
sialic aldolase;
sialic acid aldolase;
sialate lyase;
N-acetylneuraminic aldolase;
neuraminic aldolase;
N-acetylneuraminate aldolase;
neuraminic acid aldolase;
N-acetylneuraminic acid aldolase;
neuraminate aldolase;
N-acetylneuraminic lyase;
N-acetylneuraminic acid lyase;
NPL;
NALase;
NANA lyase;
acetylneuraminate pyruvate-lyase;
N-acetylneuraminate pyruvate-lyase
|
|---|
| Class |
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
 |
|---|
| Sysname |
N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
|
|---|
| Reaction(IUBMB) |
N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate [RN: R01811]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
N-acetylneuraminate [CPD: C00270]
|
|---|
| Product |
|
|---|
| Comment |
Also acts on N-glycoloylneuraminate, and on O-acetylated sialic acids, other than 4-O-acetylated derivatives.
|
|---|
| History |
EC 4.1.3.3 created 1961
|
|---|
| Pathway |
| ec00520 | Amino sugar and nucleotide sugar metabolism |
|
|---|
| Orthology |
| K01639 | N-acetylneuraminate lyase |
|
|---|
| Genes |
» show all
 |
|---|
| Reference |
|
|---|
| Authors |
COMB DG, ROSEMAN S. |
|---|
| Title |
The sialic acids. I. The structure and enzymatic synthesis of N-acetylneuraminic acid. |
|---|
| Journal |
J Biol Chem 235:2529-37 (1960) |
|---|
| Reference |
|
|---|
| Authors |
Schauer R. |
|---|
| Title |
Chemistry, metabolism, and biological functions of sialic acids. |
|---|
| Journal |
|
|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.1.3.3 |
| ExPASy - ENZYME nomenclature database: | 4.1.3.3 |
| BRENDA, the Enzyme Database: | 4.1.3.3 |
|
|---|
| LinkDB |
 |
|---|
