| Entry |
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| Name |
N-acetylneuraminate lyase;
N-acetylneuraminic acid aldolase;
acetylneuraminate lyase;
sialic aldolase;
sialic acid aldolase;
sialate lyase;
N-acetylneuraminic aldolase;
neuraminic aldolase;
N-acetylneuraminate aldolase;
neuraminic acid aldolase;
N-acetylneuraminic acid aldolase;
neuraminate aldolase;
N-acetylneuraminic lyase;
N-acetylneuraminic acid lyase;
NPL;
NALase;
NANA lyase;
acetylneuraminate pyruvate-lyase;
N-acetylneuraminate pyruvate-lyase
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| Class |
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
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| Sysname |
N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
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| Reaction(IUBMB) |
N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate [RN: R01811]
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| Reaction(KEGG) |
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| Substrate |
N-acetylneuraminate [CPD: C00270]
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| Product |
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| Comment |
Also acts on N-glycoloylneuraminate, and on O-acetylated sialic acids, other than 4-O-acetylated derivatives.
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| History |
EC 4.1.3.3 created 1961
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| Pathway |
| ec00520 | Amino sugar and nucleotide sugar metabolism |
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| Orthology |
| K01639 | N-acetylneuraminate lyase |
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| Genes |
» show all
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| Reference |
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| Authors |
COMB DG, ROSEMAN S. |
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| Title |
The sialic acids. I. The structure and enzymatic synthesis of N-acetylneuraminic acid. |
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| Journal |
J Biol Chem 235:2529-37 (1960) |
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| Reference |
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| Authors |
Schauer R. |
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| Title |
Chemistry, metabolism, and biological functions of sialic acids. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.1.3.3 |
| ExPASy - ENZYME nomenclature database: | 4.1.3.3 |
| BRENDA, the Enzyme Database: | 4.1.3.3 |
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| LinkDB |
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