| Entry |
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| Name |
(2R)-sulfolactate sulfo-lyase;
Suy;
SuyAB;
3-sulfolactate bisulfite-lyase;
sulfolactate sulfo-lyase (ambigious);
(2R)-3-sulfolactate bisulfite-lyase (pyruvate-forming)
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| Class |
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
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| Sysname |
(2R)-3-sulfolactate hydrogensulfite-lyase (pyruvate-forming)
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| Reaction(IUBMB) |
(2R)-3-sulfolactate = pyruvate + hydrogensulfite [RN: R07633]
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| Reaction(KEGG) |
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| Substrate |
(2R)-3-sulfolactate [CPD: C11537]
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| Product |
pyruvate [CPD: C00022];
hydrogensulfite
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| Comment |
Requires iron(II). This inducible enzyme participates in cysteate degradation by the bacterium Paracoccus pantotrophus NKNCYSA and in 3-sulfolactate degradation by the bacterium Chromohalobacter salexigens. The enzyme is specific for the (R) isomer of its substrate.
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| History |
EC 4.4.1.24 created 2006, modified 2011
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| Pathway |
| ec00270 | Cysteine and methionine metabolism |
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| Orthology |
| K16845 | (2R)-sulfolactate sulfo-lyase subunit alpha |
| K16846 | (2R)-sulfolactate sulfo-lyase subunit beta |
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| Genes |
» show all
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| Reference |
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| Authors |
Graham DE, White RH. |
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| Title |
Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics. |
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| Journal |
Nat Prod Rep 19:133-47 (2002) |
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| Reference |
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| Authors |
Rein U, Gueta R, Denger K, Ruff J, Hollemeyer K, Cook AM. |
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| Title |
Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in Paracoccus pantotrophus NKNCYSA. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Denger K, Cook AM |
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| Title |
Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.4.1.24 |
| ExPASy - ENZYME nomenclature database: | 4.4.1.24 |
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| LinkDB |
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