KEGG   ENZYME: 4.4.1.24
Entry
EC 4.4.1.24                 Enzyme                                 

Name
(2R)-sulfolactate sulfo-lyase;
Suy;
SuyAB;
3-sulfolactate bisulfite-lyase;
sulfolactate sulfo-lyase (ambigious);
(2R)-3-sulfolactate bisulfite-lyase (pyruvate-forming)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
(2R)-3-sulfolactate hydrogensulfite-lyase (pyruvate-forming)
Reaction(IUBMB)
(2R)-3-sulfolactate = pyruvate + hydrogensulfite [RN:R07633]
Reaction(KEGG)
R07633
Substrate
(2R)-3-sulfolactate [CPD:C11537]
Product
pyruvate [CPD:C00022];
hydrogensulfite
Comment
Requires iron(II). This inducible enzyme participates in cysteate degradation by the bacterium Paracoccus pantotrophus NKNCYSA and in 3-sulfolactate degradation by the bacterium Chromohalobacter salexigens. The enzyme is specific for the (R) isomer of its substrate.
History
EC 4.4.1.24 created 2006, modified 2011
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K16845  (2R)-sulfolactate sulfo-lyase subunit alpha
K16846  (2R)-sulfolactate sulfo-lyase subunit beta
Genes
AHN: NCTC12129_02754 NCTC12129_02755(garD_1)
GHO: AL542_00730 AL542_00735
PPHE: PP2015_2374
CEB: B0D95_10315
CEK: D0B88_08160
CEG: D0C16_11215
APRS: BI364_08775 BI364_08780
CSA: Csal_1765 Csal_1766
HBE: BEI_0833(suyA) BEI_0834(suyB)
SVA: SVA_1848 SVA_1849
CGD: CR3_0181(suyA) CR3_0182(suyB)
CABA: SBC2_17550 SBC2_17560(suyB_1)
LIH: L63ED372_00897(suyB) L63ED372_00898(suyA)
HAR: HEAR3336 HEAR3337(uxaA)
RGE: RGE_25210(suyB) RGE_25220
DTR: RSDT_0106(suyA) RSDT_0107(suyB)
VGO: GJW-30_1_00129(suyB_1) GJW-30_1_00130(suyA)
MARU: FIU81_03600(suyA) FIU81_03605(suyB)
SAY: TPY_1962(uxaA) TPY_1963
RHA: RHA1_ro08847(suyA) RHA1_ro08848(suyB)
SSO: SSO1259(garD) SSO1260
 » show all
Reference
1  [PMID:12013276]
  Authors
Graham DE, White RH.
  Title
Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics.
  Journal
Nat Prod Rep 19:133-47 (2002)
DOI:10.1039/b103714p
Reference
2  [PMID:15758220]
  Authors
Rein U, Gueta R, Denger K, Ruff J, Hollemeyer K, Cook AM
  Title
Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in Paracoccus pantotrophus NKNCYSA.
  Journal
Microbiology 151:737-47 (2005)
DOI:10.1099/mic.0.27548-0
  Sequence
Reference
3  [PMID:20007648]
  Authors
Denger K, Cook AM
  Title
Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase.
  Journal
Microbiology 156:967-74 (2010)
DOI:10.1099/mic.0.034736-0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.24
IUBMB Enzyme Nomenclature: 4.4.1.24
ExPASy - ENZYME nomenclature database: 4.4.1.24
BRENDA, the Enzyme Database: 4.4.1.24
CAS: 1256650-35-7
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