| Entry |
|
|---|
| Name |
cyclic pyranopterin monophosphate synthase;
MOCS1B (gene name);
moaC (gene name);
cnx3 (gene name)
|
|---|
| Class |
Lyases;
Phosphorus-oxygen lyases;
Phosphorus-oxygen lyases (only sub-subclass identified to date)
|
|---|
| Sysname |
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate lyase (cyclic pyranopterin phosphate-forming)
|
|---|
| Reaction(IUBMB) |
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate [RN: R11372]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate [CPD: C21310]
|
|---|
| Product |
cyclic pyranopterin phosphate [CPD: C18239];
diphosphate [CPD: C00013]
|
|---|
| Comment |
The enzyme catalyses an early step in the biosynthesis of the molybdenum cofactor (MoCo). In bacteria and plants the reaction is catalysed by MoaC and Cnx3, respectively. In mammals the reaction is catalysed by the MOCS1B domain of the bifuctional MOCS1 protein, which also catalyses EC 4.1.99.22, GTP 3',8-cyclase.
|
|---|
| History |
EC 4.6.1.17 created 2011 as EC 4.1.99.18, part transferred 2016 to EC 4.6.1.17
|
|---|
| Pathway |
|
|---|
| Orthology |
| K03637 | cyclic pyranopterin monophosphate synthase |
| K20967 | GTP 3',8-cyclase / cyclic pyranopterin monophosphate synthase |
|
|---|
| Genes |
» show all
|
|---|
| Reference |
|
|---|
| Authors |
Rieder C, Eisenreich W, O'Brien J, Richter G, Gotze E, Boyle P, Blanchard S, Bacher A, Simon H |
|---|
| Title |
Rearrangement reactions in the biosynthesis of molybdopterin--an NMR study with multiply 13C/15N labelled precursors. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Wuebbens MM, Rajagopalan KV |
|---|
| Title |
Investigation of the early steps of molybdopterin biosynthesis in Escherichia coli through the use of in vivo labeling studies. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Hover BM, Tonthat NK, Schumacher MA, Yokoyama K |
|---|
| Title |
Mechanism of pyranopterin ring formation in molybdenum cofactor biosynthesis. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.6.1.17 |
| ExPASy - ENZYME nomenclature database: | 4.6.1.17 |
|
|---|
| LinkDB |
|
|---|
