Entry |
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Name |
salicylate---CoA ligase;
sdgA (gene name)
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Class |
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
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Sysname |
salicylate:CoA ligase (AMP-forming)
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Reaction(IUBMB) |
ATP + salicylate + CoA = AMP + diphosphate + 2-hydroxybenzoyl-CoA (overall reaction) [RN: R12642];
(1a) ATP + salicylate = diphosphate + (2-hydroxybenzoyl)adenylate [RN: R12640];
(1b) (2-hydroxybenzoyl)adenylate + CoA = AMP + 2-hydroxybenzoyl-CoA [RN: R12641]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzyme, characterized from the bacteria Thauera aromatica and Streptomyces sp. WA46, participates in a salicylate degradation pathway. It activates salicylate by its adenylation to (2-hydroxybenzoyl)adenylate, followed by the transfer of the activated compound to coenzyme A.
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History |
EC 6.2.1.65 created 2020
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Orthology |
K24408 | salicylate---CoA ligase |
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Genes |
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Reference |
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Authors |
Bonting CF, Fuchs G |
Title |
Anaerobic metabolism of 2-hydroxybenzoic acid (salicylic acid) by a denitrifying bacterium. |
Journal |
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Reference |
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Authors |
Ishiyama D, Vujaklija D, Davies J |
Title |
Novel pathway of salicylate degradation by Streptomyces sp. strain WA46. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 6.2.1.65 |
ExPASy - ENZYME nomenclature database: | 6.2.1.65 |
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LinkDB |
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