| Entry |
|
|---|
| Name |
salicylate---CoA ligase;
sdgA (gene name)
|
|---|
| Class |
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
|
|---|
| Sysname |
salicylate:CoA ligase (AMP-forming)
|
|---|
| Reaction(IUBMB) |
ATP + salicylate + CoA = AMP + diphosphate + 2-hydroxybenzoyl-CoA (overall reaction) [RN: R12642];
(1a) ATP + salicylate = diphosphate + (2-hydroxybenzoyl)adenylate [RN: R12640];
(1b) (2-hydroxybenzoyl)adenylate + CoA = AMP + 2-hydroxybenzoyl-CoA [RN: R12641]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
|
|---|
| Product |
|
|---|
| Comment |
The enzyme, characterized from the bacteria Thauera aromatica and Streptomyces sp. WA46, participates in a salicylate degradation pathway. It activates salicylate by its adenylation to (2-hydroxybenzoyl)adenylate, followed by the transfer of the activated compound to coenzyme A.
|
|---|
| History |
EC 6.2.1.65 created 2020
|
|---|
| Orthology |
| K24408 | salicylate---CoA ligase |
|
|---|
| Genes |
|
|---|
| Reference |
|
|---|
| Authors |
Bonting CF, Fuchs G |
|---|
| Title |
Anaerobic metabolism of 2-hydroxybenzoic acid (salicylic acid) by a denitrifying bacterium. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Ishiyama D, Vujaklija D, Davies J |
|---|
| Title |
Novel pathway of salicylate degradation by Streptomyces sp. strain WA46. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 6.2.1.65 |
| ExPASy - ENZYME nomenclature database: | 6.2.1.65 |
|
|---|
| LinkDB |
|
|---|
