| Entry |
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| Name |
formate---tetrahydrofolate ligase;
formyltetrahydrofolate synthetase;
10-formyltetrahydrofolate synthetase;
tetrahydrofolic formylase;
tetrahydrofolate formylase
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| Class |
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
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| Sysname |
formate:tetrahydrofolate ligase (ADP-forming)
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| Reaction(IUBMB) |
ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate [RN: R00943]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
In eukaryotes occurs as a trifunctional enzyme also having methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) and methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) activity.
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| History |
EC 6.3.4.3 created 1961
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| Pathway |
| ec00720 | Carbon fixation pathways in prokaryotes |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K00288 | methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase |
| K01938 | formate--tetrahydrofolate ligase |
| K13402 | monofunctional C1-tetrahydrofolate synthase, mitochondrial |
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| Genes |
» show all
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| Reference |
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| Authors |
JAENICKE L, BRODE E. |
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| Title |
[Research on monocarbon compounds. I. The tetrahydrofolate formylase from pigeon liver. Purification and mechanism.] |
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| Journal |
Biochem Z 334:108-32 (1961) |
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| Reference |
2 |
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| Authors |
Long, C.W., Levitzki, A., Houston, L.L and Koshland, D.E., Jr. |
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| Title |
Subunit structures and interactions of CTP synthetase. |
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| Journal |
Fed Proc 28:342 (1969) |
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| Reference |
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| Authors |
RABINOWITZ JC, PRICER WE Jr. |
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| Title |
Formyltetrahydrofolate synthetase. I. Isolation and crystallization of the enzyme. |
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| Journal |
J Biol Chem 237:2898-902 (1962) |
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| Reference |
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| Authors |
WHITELEY HR, OSBORN MJ, HUENNEKENS FM. |
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| Title |
Purification and properties of the formate-activating enzyme from Micrococcus aerogenes. |
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| Journal |
J Biol Chem 234:1538-43 (1959) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 6.3.4.3 |
| ExPASy - ENZYME nomenclature database: | 6.3.4.3 |
| BRENDA, the Enzyme Database: | 6.3.4.3 |
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| LinkDB |
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