Escherichia coli O18 K1 H7 UTI89 (UPEC): UTI89_C4577
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Entry
UTI89_C4577 CDS
T00338
Symbol
metH
Name
(GenBank) 5-methyltetrahydrofolate--homocysteine methyltransferase
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
eci
Escherichia coli O18:K1:H7 UTI89 (UPEC)
Pathway
eci00270
Cysteine and methionine metabolism
eci00450
Selenocompound metabolism
eci00670
One carbon pool by folate
eci01100
Metabolic pathways
eci01110
Biosynthesis of secondary metabolites
eci01230
Biosynthesis of amino acids
eci04980
Cobalamin transport and metabolism
Module
eci_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
eci00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
UTI89_C4577 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
UTI89_C4577 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
UTI89_C4577 (metH)
09150 Organismal Systems
09154 Digestive system
04980 Cobalamin transport and metabolism
UTI89_C4577 (metH)
Enzymes [BR:
eci01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
UTI89_C4577 (metH)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
ABE09985
UniProt:
Q1R3S9
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All DBs
Position
4469453..4473136
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AA seq
1227 aa
AA seq
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MSSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSK
PEVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTA
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILI
ETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAE
AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLI
AGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPAEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPTELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANTQQAEWRSWEVN
KRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDL
GVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPR
TPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGVEAQRLFKDANDMLDKLSAEKMLNPRGVVGLFPANRVGDDIEIYRDETRT
HVINVSHHLRQQTEKTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQH
DDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYP
ACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
EDYARRKGMSVTEVERWLAPNLGYDAE
NT seq
3684 nt
NT seq
+upstream
nt +downstream
nt
gtgagcagcaaagtggaacaactgcgtgcgcagttaaatgaacgtattctggtgctggac
ggcggtatgggcaccatgatccagagctatcgactgaacgaagccgattttcgtggtgaa
cgctttgccgactggccatgcgatctcaaaggcaacaacgacctgctggtgctcagcaaa
ccggaagtgatcgccgctatccacaacgcctactttgaagcgggcgcggatatcatcgaa
accaacaccttcaactccacgactattgcgatggcggattaccaaatggaatccctgtcg
gcggaaatcaactttgcagcggcgaaactggcgcgcgcctgtgccgacgagtggactgcc
cgcacgccggagaaaccgcgctacgttgccggtgttctcggcccgaccaaccgcacggcg
tctatttctccggacgtcaacgatccggcattccgcaacatcacttttgaccagctggtg
gcggcttatcgagaatccaccaaagcgctggtggaaggtggcgcggacctgatcctgatt
gaaaccgttttcgacacccttaacgccaaagcggcggtctttgcggtgaaaacggagttt
gaagcgctgggcgttgagctgccgattatgatctccggcaccatcaccgacgcctccggg
cgcacgctctccgggcagaccactgaagcgttttacaactccctgcgccacgccgaagcg
ctgacctttggcctgaactgtgcgctggggccagacgaactgcgccagtacgtacaggaa
ctgtcgcgtattgcggaatgctatgtcaccgcccacccgaacgccgggctgcccaacgcc
tttggtgaatacgatctcgacgccgacacgatggcaaaacagatacgtgaatgggcagaa
gcgggctttctcaatatcgtcggcggctgctgcggcaccacgccacaacatattgcagcg
atgagtcgtgcagtagaaggattagcgccgcgcaaactaccggaaattcccgtagcctgc
cgtttgtccggcctggagccgctgaacattggcgaagatagcctgtttgtgaacgtgggt
gaacgcaccaacgtcaccggttccgctaagttcaagcgcctgatcaaagaagagaaatac
agcgaggcgctggatgtggcgcgtcagcaggtggaaaacggtgcgcagattatcgatatc
aacatggatgaagggatgctcgacgccgaagcggcgatggtgcgttttctcaatctgatt
gccggtgaaccggatatcgctcgcgtgccgattatgatcgactcctcaaaatgggacgtt
attgaaaaaggtctgaagtgtatccagggcaaaggcattgttaactctatctcgatgaaa
gagggtgtcgacgcctttatccatcacgcgaaactgttgcgtcgctacggtgcggcagta
gtggtaatggcttttgacgaacagggccaggccgatacccgcgcacggaaaatcgagatt
tgccgtcgggcgtacaaaatcctcaccgaagaggttggcttcccggctgaagatatcatc
ttcgacccgaacatcttcgcggtcgcaactggcattgaagagcacaacaattacgcacag
gactttatcggcgcgtgtgaagacatcaaacgtgaactgccgcacgcactgatttccggc
ggcgtttctaacgtgtcgttctcgtttcgtggcaacgatccggtgcgcgaagccattcac
gcggtgttcctctactacgctattcgcaatggcatggatatggggatcgtcaacgccggg
caactggcgatttacgacgacctgcctaccgaactacgcgacgcggtggaggatgtgatc
ctcaaccgtcgcgacgatggcaccgagcgtttactggagcttgccgagaaatatcgcggc
agcaaaaccgacgacaccgctaacacccagcaggcggagtggcgctcgtgggaagtgaat
aaacgtctggaatactcgctggtcaaaggcattaccgagtttatcgagcaggataccgaa
gaagcccgccagcaggctacgcgtccgattgaagtgattgaaggcccgttgatggacggc
atgaacgtggtcggcgacctgtttggcgagggcaaaatgttcctgccgcaggtggtgaaa
tcggcgcgcgtcatgaaacaggcggtggcgtatctcgaaccgtttattgaagccagcaaa
gagcagggtaaaaccaacggcaagatggtgatcgccaccgtgaaaggcgatgtccacgac
atcggtaaaaatatcgttggcgtggtgctgcaatgtaacaactacgaaattgtcgatctc
ggcgtgatggtgcctgcggaaaaaattctccgtaccgctaaagaagtgaatgctgatttg
attggcctttcagggctgatcacgccgtcgctggacgagatggttaacgtggcgaaagag
atggagcgtcagggcttcaccattccgctattgattggcggcgcgaccacctcaaaagcg
cacacggcggtgaaaatcgagcagaactacagcggcccgacggtgtatgtgcagaacgca
tcgcgcaccgttggtgtggtggcggcgttgctttccgacactcagcgcgatgatttcgtt
gctcgtacccgcaaggagtacgaaaccgtgcgtattcagcacggacgaaagaaaccacgc
acaccaccggtcacgctggaagcggcgcgtgataacgacttcgcttttgactggcaggct
tacacgccgccggtggcgcaccgtctcggtgtgcaggaagtcgaagccagcatcgaaacg
ctgcgtaattacatcgactggacgccgttctttatgacctggtcgctggccgggaagtat
ccgcgcattctggaagatgaagtggtaggtgttgaggcgcagcggctgtttaaagacgcc
aacgacatgctggataaattaagcgccgaaaaaatgctgaacccgcgtggcgtggtgggc
ctgttcccggcaaaccgtgtgggtgatgacattgaaatctaccgtgacgaaacgcgtacc
catgtgattaatgtcagccaccatctacgccaacagaccgaaaaaaccggcttcgctaac
tactgtctcgctgacttcgttgcgccgaagctttctggtaaagcagattacatcggcgca
tttgccgtgactggcgggctggaagaggacgcactggctgatgcctttgaagcacagcat
gatgattacaacaaaatcatggtgaaagcgcttgccgaccgtctggcggaagcctttgct
gagtatctccatgagcgtgtgcgtaaagtctactggggctatgcgccgaacgagaacctc
agcaacgaagagctgatccgcgaaaactaccagggcatccgtccggcaccgggctaccct
gcctgcccggaacatacggaaaaagccacaatctgggagctgctggaagtggaaaaacat
accggtatgaaactcacggaatccttcgccatgtggccgggtgcatcggtttcgggttgg
tacttcagtcatccagacagcaagtattacgcggtggcgcaaattcagcgcgatcaggtt
gaagactatgcccgccgtaaaggaatgagcgttaccgaagtcgagcgttggttggcaccg
aatctggggtatgatgccgagtaa
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